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Background: Allergic disease reflects specific inflammatory processes initiated by interaction between allergen and allergen-specific IgE. Specific immunotherapy (SIT) is an effective long-term treatment option, but the mechanisms by which SIT provides desensitization are not well understood. Objective: Our aim was to characterize IgE sequences expressed by allergen-specific B cells over a 3-year
Using electronic health records data and machine learning to guide future decisions needs to address challenges, including 1) long/short-term dependencies and 2) interactions between diseases and interventions. Bidirectional transformers have effectively addressed the first challenge. Here we tackled the latter challenge by masking one source (e.g., ICD10 codes) and training the transformer to pre
Type 2 diabetes and dementia are associated, but it is unclear whether the two diseases have common genetic risk markers that could partly explain their association. It is also unclear whether the association between the two diseases is of a causal nature. Furthermore, few studies on diabetes and dementia have validated dementia end-points with high diagnostic precision. We tested associations bet
Many research studies have been done to investigate different aspects of environmental challenges. In the product development context, there have been attempts to reduce the environmental impacts of associated activities including the production processes themselves. As a result, various technological improvements have been made and new production processes e.g. powder metallurgy technologies have
Telomeres are the conservative sequence repeats located at the end of linear chromosomes that have been the focus of intensive research across many disciplines over the last four decades. They function as a cap to protect the chromosome ends from fusion to other chromosomes and to prevent chromosome degradation. Telomere shortening is thought to be involved in ageing, reflecting or even causing ag
Background Physical activity improves health, exercise tolerance and quality of life in adults with congenital heart disease (CHD), and exercise training is in most patients a high-benefit low risk intervention. However, factors that influence the confidence to perform exercise training, i.e. exercise self-efficacy (ESE), in CHD patients are virtually unknown. We aimed to identify factors related
Background: Parents’ birth experiences affect bonding with their infant, which in turn may influence the child's future health. Parents’ satisfaction with childbirth is multi-dimensional and dependent on both expectations and experiences. Increasing involvement of partners in intrapartum care may lead to an assumption that the birthing couple shares attitudes and expectations of intrapartum care.
The demand for high data rates in a wireless communication system has experienced a remarkable growth over the last years. This demand is continually increasing with the growing number of wirelessly connected devices. Thus, there is a continuing hunt for increasing the data transmission rate in wireless communication systems. To increase the data rate, the modern wireless communication system cann
Denna studies syfte är att identifiera om det finns ett behov av att utforma läromedel för lärare i Musikproduktion, och hur lärare arbetar med denna kurs idag. Detta har undersökts dels med en enkätstudie samt kvalitativa intervjuer med två pedagoger som undervisar i Musikproduktion på två gymnasieskolor. Litteraturgenomgången belyser vilka behov som finns i skolan idag där perspektiv på elever, The aim of this study is to identify if there is a need to produce educational materials for teachers in “Musikproduktion”, and how teachers work with this course today. This has been done partly through a survey study and qualitative interviews with two teachers in music production in two Swedish upper secondary schools. The literature review explores the need that exists in schools today where p
Development of a new spatially complete and daily continuous lake surface water temperature dataset for Lake Vänern, Sweden Keywords: Physical Geography, Ecosystem Analysis, Remote Sensing, Data Fusion, Reanalysis Product, Lake Surface Water Temperature, Hydrology Lake Surface Water Temperature (LSWT) is an important indicator to monitor changes due to climate change on a regional scale. Changes
Denna uppsats utreder hur finansiella produkter klassificeras i inkomstslaget kapital, och vilka skatterättsliga skillnader som finns mellan de olika kategorierna i inkomstslaget. Utifrån praxis och inkomstskattelagens systematik redogörs för hur en avyttring av kryptovalutan Bitcoin ska klassificeras och beskattas. Gällande rätt analyseras sedan mot bakgrund av principen om likformighet och skattThis paper examines how financial products are classified within the capital gains bracket and which tax differences follow from such classification. Based on practice and the methodology of the Income tax act, the paper describes how a divestment of the cryptocurrency Bitcoin should be classified and taxed. The result is thereafter analyzed from the perspective of the principle of uniformity and
Recessive diseases arise when both copies of a gene are impacted by a damaging genetic variant. When a patient carries two potentially causal variants in a gene, accurate diagnosis requires determining that these variants occur on different copies of the chromosome (that is, are in trans) rather than on the same copy (that is, in cis). However, current approaches for determining phase, beyond pare
Arbetet fokuserar på att ge en tydlig bakgrund till vad dagens projektingenjörer har för uppgift i ett ledande projekt. En frågeställning genom arbetet kommer att vara jämförelse mellan Trafikverkets definition av projektingenjörer kontra konsultens definition av projektingenjörer. Upplever projekteringsorganisationerna de krav som ställs på projektingenjörerna? Finns det en tydlig skillnad på kon
Popular Abstract in Swedish Eld har fascinerat människan i alla tider. Att sitta och värma sig vid en lägereld, sjunga sånger eller bara titta på hur elden rör sig är något de flesta har upplevt. Hur många har egentligen funderat på var värmen kommer ifrån, hur den gula färgen uppstår eller vad eld egentligen består av? Några av frågorna finns det nu svar på, men fortfarande finns det mycket att uThe work presented in the thesis covers the use of laser-induced fluorescence (LIF) and photofragmentation laser-induced fluorescence (PFLIF) with short laser pulses to determine species concentrations in different combustion environments. To attain quantitative species concentrations using LIF investigations of the influence of collisional quenching on the fluorescence signal strength is of vital
