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Objective: To describe longitudinal changes of Magnetic Resonance Imaging (MRI) features in the medial vs lateral tibiofemoral (TF) and patellofemoral (PF) compartments, in knees with no radiographic osteoarthritis (OA) at baseline. Design: In 340 individuals from the Osteoarthritis Initiative aged 45–55 years (51% women) with 430 knees at risk for OA and 250 not at risk, we assessed MRI scans of
