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Breast cancer prognosis is frequently good but a substantial number of patients suffer from relapse. The death receptor ligand TRAIL can in combination with Smac mimetics induce apoptosis in some luminal-like ER-positive breast cancer cell lines, such as CAMA-1, but not in MCF-7 cells. Here we show that TRAIL and the Smac mimetic LCL161 induce noncanonical NF-κB and IFN signaling in ER-positive MC
Ammonia (NH3) is an inorganic substance considered as a promising fuel for power sector decarbonization. As a result of the absence of carbon in its structure, ammonia is capable of producing energy with zero CO2 emissions when burned. However, the combustion of NH3 presents several challenges as a result of its low reactivity and low flame speed as well as the formation of large quantities of nit
Seed morphology (testa ornamentation and seed shape) and allozyme variation were investigated in three closely related and partially sympatric taxa of Silene in the Nordic region. Within this region, Silene vulgaris is a widespread weed of anthropogenic habitats. The two subspecies of Silene uniflora are restricted to naturally open habitats; ssp. uniflora has a coastal distribution, whereas the S
Allozyme data were used to assess the genetic structure between 37 sympatric populations of the species-pair Silene vulgaris and S. uniflora ssp. petraea, and to infer levels of intra- and interspecific gene flow in the two species. Silene vulgaris is a geographically widespread weed of disturbed habitats whereas S. uniflora ssp. petraea is endemic to the Baltic islands of Öland and Gotland. On Öl
The article analyses how hunting tourism businesses in Sweden navigate in the nexus between moral and economic value spheres. Through the analytical lens of ‘moral gatekeeper’, the business operators are depicted as acting from a position where they navigate in a contested space. The analysis demonstrates how the operators balance different norms and practices of recreational hunting, wildlife man
We present a measurement of the transverse single-spin asymmetry for π0 and η mesons in p↑+p collisions in the pseudorapidity range |η|
In this study, we performed an experimental investigation of water absorption and penetration in clay brick masonry exposed to cyclic water spraying by employing a newly developed test setup. Several parameters, including brick absorption properties and different mortar joint profiles, were investigated. The specimens were exposed to a uniform water spray rate ranging between 1.7 and 3.8 l/m2/h, a
BACKGROUND: Mesoamerica is severely affected by an epidemic of Chronic Kidney Disease of non-traditional origin (CKDnt), an epidemic with a marked variation within countries. We sought to describe the spatial distribution of CKDnt in Mesoamerica and examine area-level crop and climate risk factors.METHODS: CKD mortality or hospital admissions data was available for five countries: Mexico, Guatemal
Low impact falls to the side are the main cause of hip fractures in elderly. Finite element (FE) models of the proximal femur may help in the assessment of patients at high risk for a hip fracture. However, extensive validation is essential before these models can be used in a clinical setting. This study aims to use strain measurements from bilateral digital image correlation to validate an FE mo
The natural products pulchrol and pulchral, isolated from the roots of the Mexican plant Bourreria pulchra, have previously been shown to possess an antiparasitic activity toward Trypanosoma cruzi, Leishmania braziliensis and L. amazonensis, protozoa responsible for the Chagas disease and leishmaniasis. These infections have been classified as neglected diseases, and still require the development
In this paper, the enhanced heat transfer performance and mechanism of a multi-tube heat exchanger (MTHX) with outward helically corrugated tubes (HCTs) are investigated by a numerical approach. Three types of tube arrangement (circle, square and triangle, indicated as CTA, STA and TSA, respectively) and four different tube spacings (1.25, 1.375, 1.5 and 1.625) are compared for Reynolds (Re) numbe
Cell immobilization and co-culture techniques have gained attention due to its potential to obtain high volumetric hydrogen productivities (QH2). Chitosan retained biomass in the fermentation of co-cultures of Caldicellulosiruptor saccharolyticus and C. owensensis efficiently, up to a maximum dilution rate (D) of 0.9 h−1. Without chitosan, wash out of the co-culture occurred earlier, accompanied w
AimHirschsprung's disease is a congenital disorder requiring surgery. Most children operated on for Hirschsprung's disease experience postoperative bowel dysmotility. Although various food is known to influence bowel motility, evidence of diet's role and dietary guidelines in treatment of bowel dysfunction in Hirschsprung's disease is lacking. The aim was to explore parental experiences of dietary
Understanding of the mechanics of the brittle-ductile transition (BDT) in porous limestone is significantly more challenging than for sandstone because of the lack of consistent acoustic emission activity in limestone, meaning that one must rely on alternative techniques. In this paper, we investigate systematically the failure modes in Indiana limestone using X-ray microComputed Tomography imagin
Bronchiolitis obliterans syndrome (BOS), a common form of chronic lung allograft dysfunction, is the major limitation to long-term survival after lung transplantation. The histological correlate is progressive, fibrotic occlusion of small airways, obliterative bronchiolitis lesions, ultimately leading to organ failure. The molecular composition of these lesions is unknown. By laser-capture microdi
OBJECTIVE: The objective was to examine the association between primary care consultations and a Care Need Index (CNI) used to compensate Swedish primary care practices for the extra workload associated with patients with low socioeconomic status.DESIGN: Observational study combining graphical analysis with linear regressions of cross-sectional administrative practice-level data.SETTING: Three Swe
How do regions change their development path? We contribute to the growing literature on agency in regional development by combining it with a focus on the institutions that shape, support and constrain change agency in pursuit of different types of development paths. We answer the call for micro-level perspectives on regional economic change, using an in-depth and comparative case study approach.
Traumatic brain injury and stroke result in hemiplegia, hemiparesis, and asymmetry in posture. The effects are mostly contralateral; however, ipsilesional deficits may also develop. We here examined whether ablation brain injury and controlled cortical impact (CCI), a rat model of clinical focal traumatic brain injury, both centered over the left or right sensorimotor cortex, induced hindlimb post
