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Objective: Giant cell arteritis (GCA) is a treatable, but potentially sight- and life-threatening form of systemic vasculitis. Prompt and correct diagnosis is therefore important. Temporal artery biopsy (TAB) is the gold standard for diagnosing GCA, but is associated with risks. There is no reliable non-invasive technique for the diagnosis of GCA. Ultrasound centre frequency shift (CFS) is a novel
Modelling has been a mainstay of conventional planning support tools (PSTs) since the 1960s and is instrumental in transport and land use planning decision-making. Numerous studies have been conducted to model the potential impacts of emerging vehicle automation and sharing technologies. A systematic review of recent modelling studies of autonomous and shared vehicles in the research literature ex
Acute respiratory distress syndrome (ARDS) is a life-threatening, high mortality pulmonary condition characterized by acute lung injury (ALI) resulting in diffuse alveolar damage. Despite progress regarding the understanding of ARDS pathophysiology, there are presently no effective pharmacotherapies. Due to the complexity and multiorgan involvement typically associated with ARDS, animal models rem
This article outlines a number of new approaches in the history of medicine and medical humanities to the study of medical case histories from a genre-theoretical vantage point. Differentiating between morphological and structuralist concepts of genre, the essay proposes the investigation of similarities and differences among specific series of case histories in order to recover evolving, changing
Handwriting is an important component of academic curricula and grapho-motor skills (GMS) support learning, reading, memory and self-confidence. Teachers and clinicians report increase in children experiencing problems with acquiring fluid and legible handwriting. To date gold-standard tests evaluating children's GMS, mostly rely on pen and paper tests, requiring extensive coding time and subject
This chapter provides conceptual and empirical foundations for smart specialization, a policy approach of far-reaching importance in the European context. We interpret the very notion as “diversified” specialization into areas of existing or potential competitive advantage, which differentiates a region/nation from others. “Smart” relates to the identification of these areas through a process of e
Extracorporeal membrane oxygenation (ECMO) occupies an increasingly important position in the clinic for the management of cardiac and/or pulmonary failure. As a rescue therapy, ECMO can support patients following respiratory or cardiac compromise to act as a bridge to recovery, to decision, or to transplant. This chapter reviews briefly the history of ECMO implementation as well as device modes,
What can artificial intelligence learn from the cognitive sciences? We review some fundamental aspects of how human cognition works and relate it to different brain structures and their function. A central theme is that cognition is very different from how it is envisioned in classical artificial intelligence which offers a novel path toward intelligent systems that in many ways is both simpler an
Extreme environmental conditions make soils of the hyper-arid Atacama Desert one of the most hostile habitats for life on the planet. During the short intervals of moisture availability that occur, it remains unresolved how soil microorganisms physiologically respond to such dramatic environmental changes. Therefore, we simulated a precipitation event – without (H2O) and with (H2O + C) labile carb
Popular Abstract in SwedishVad är åldrande? När började man över huvud taget tala om ”åldrande”? När fick ordet ”pensionär” den betydelse vi är vana vid idag? I Åldrandet och språket studeras ord och uttryck för att ringa in vad man har menat med hög ålder och åldrande i Sverige under hundraårsperioden mellan 1875 och 1975. Frågor kring hög ålder och åldrande har stor aktualitet idag. I Sverige ocThis thesis analyses how old age and ageing were manifested and understood in Sweden from approximately 1875 to 1975. It thus aims to provide historical background to current debate about for instance the retirement age and how to best care for the elderly. Encyclopaedia entries from both the beginning and the end of this period describe ageing as a medical process of physical decline. Since much
The Gram-positive species Streptococcus pneumoniae is a human pathogen causing severe local and life-threatening invasive diseases associated with high mortality rates and death. We demonstrated recently that pneumococcal endopeptidase O (PepO) is an ubiquitously expressed, multifunctional plasminogen and fibronectin binding protein facilitating host cell invasion and evasion of innate immunity. I
Streptococcus pneumoniae infections remain a major cause of morbidity and mortality worldwide. Therefore a detailed understanding and characterization of the mechanism of host cell colonization and dissemination is critical in order to gain control over this versatile pathogen. Here we identified a novel 72 kDa pneumococcal protein endopeptidase O (PepO), as a plasminogen and fibronectin binding p
Hematopoietic stem cells (HSCs) maintain blood through self-renewal and differentiation. Although HSC transplantation is the only cure for various blood disorders, generating and maintaining HSCs in vitro remains challenging, partly due to a limited understanding of the cellular and molecular mechanisms underlying human HSC ontogeny. In embryos, definitive HSCs arise from hemogenic endothelium via
Leukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report massive AML cell infiltration in the skin in a transplantation-induced MLL-AF9 AML mouse model. These AML cells could regenerate AML after transplantat
This chapter argues for the importance of developing historical reference frames for Scandinavian children born to foreign fighters in the so-called Islamic State (IS)—that is, seeing them as children born of war (CBOW) rather than as “IS children”—to strengthen the case for their repatriation from Kurdish detention camps. Politicians across the region today stress they want to repatriate the chil
This chapter explores the value of gender equality in two areas of EU external relations: enlargement to include the accession countries of Central and Eastern Europe, and development policy with an emphasis on health, AIDS, and population policies. First, we will analyse the origins, history and institutionalisation of gender equality mechanisms in the European Union. Second, the impact of this v
This contribution explores the attempts by international humanitarian agencies and the post-genocide Rwandan state respectively to deal with exceptionality created by the genocide and return to normality. It does so by comparing two kinds of camps that deal with exceptional life: the refugee camps for Hutu who fled after the genocide and the Rwandan government's ingando re-education camps. While t
