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Acquisition of complement regulators is a virulence strategy used by nontypeable Haemophilus influenzae (NTHi) to evade complement-mediated killing by the host. The major outer membrane protein of NTHi, P5, binds C4b-binding protein and factor H to promote bacterial serum resistance. We show that P5 also binds vitronectin, which inhibits the formation of the membrane attack complex at the terminal

We have generated two reporter plasmids that either monitor expression of human papillomavirus type 16 (HPV16) E2 mRNAs using splice site SA2709 or HPV16 E1C mRNAs utilizing splice site SA2582. In plasmid pE2sLuc, the entire E2 open reading frame was replaced by the secreted luciferase (sLuc) reporter gene and in the pE1nLuc plasmid the E1/E1C open reading frame was fused in frame with the nanoluc

Objectives: To evaluate the test–retest reliability of a novel laboratory-based protocol for inducing and measuring head acceleration in multiple directions under anticipated and unanticipated conditions. Design: Laboratory-based test–retest reliability study. Methods: Thirty physically active adults (50% female) completed standardized head perturbations using a custom-built apparatus. Perturbatio

Background: Normal hand function relies on a finely tuned interaction between the sensory and motor systems within the central and peripheral nervous systems. The central nervous system continuously adapts to changed activity, environmental changes, learning, and injury — a phenomenon known as neuroplasticity. The neuroplasticity is a life-long ability and presents opportunities for therapeutic in

Background: Altered metabolism after liver surgery adds complexity topostoperative pain management. Opioids administered via intravenousPatient Controlled Analgesia (PCA) is one of the main alternatives forinitial pain management. Paracetamol is considered potentially dangerousafter liver surgery but used selectively. This study evaluates whether thereis a difference in patient outcome after hepat

The short-time iterative adaptive approach is a spectral estimation alternative to the short-time Fourier transform for non-stationary vibration analysis. This technique offers a reduction in leakage effects and a higher resolution in exchange for a higher computational complexity. The short-time iterative adaptive approach can be summarized as a high-resolution data-dependent approach which has b

Introduction: Problems with adequately regulating aggression are comon in people with mild to borderline intellectual disabilities (MBID). Learning through experience has been shown to be effective in MBID. Therefore, we adapted an aggression prevention training that uses virtual reality (VR), which was initially made for a forensic psychiatric population. We aimed to assess the feasibility of thi

Dopaminergic (DA) neurons exhibit significant diversity characterized by differences in morphology, anatomical location, axonal projection pattern, and selective vulnerability to disease. More recently, scRNAseq has been used to map DA neuron diversity at the level of gene expression. These studies have revealed a higher than expected molecular diversity in both mouse and human DA neurons. However

Extraordinary transmission of electromagnetic power through sub-wavelength apertures is usually observed in a narrow bandwidth range and the transmission outside this range is low. In this paper, it is shown that the transmission through periodic apertures in an otherwise perfectly electric conducting sheet satisfies a sum rule that relates wavelength regions with transmission above a threshold wi

Rapporten utgör ett underlag till Jämställdhetsmyndighetens fördjupadeuppföljning av det jämställdhetspolitiska delmålet att mäns våld mot kvinnor skaupphöra.

The anaphylatoxic peptide C3a is a pro-inflammatory mediator generated during complement activation, whose specific G protein coupled receptor is expressed on granulocytes, monocytes, mast cells, activated lymphocytes, and in the nervous tissue. We have generated RBL-2H3 cell clones stably expressing mutants of the human C3a-receptor (C3aR) with combined alanine (Ala) substitutions of ten C-termin

In recent years the importance of strong brands has come very much into focus both among theoreticians and practitioners. In order to gain a better understanding of the nature of brand strength, I have chosen to analyse the branding process. The overriding aim of this analysis is to develop a theoretical framework and typology with which to facilitate our understanding of how powerful brands can b

Knockout of caspase-8, a cysteine protease that participates in the signaling for cell death by receptors of the TNF/nerve growth factor family, is lethal to mice in utero. To explore tissue-specific roles of this enzyme, we established its conditional knockout using the Cre/loxP recombination system. Consistent with its role in cell death induction, deletion of caspase-8 in hepatocytes protected

Popular Abstract in Swedish Språklig bearbetning och kontextuell påverkan En studie av förskolebarn med språkstörning Bakgrund Avhandlingen behandlar olika aspekter av språklig bearbetning hos barn med språkstörning. Barn med språkstörning har svårt att tillägna sig sitt modersmål trots att de växer upp i en enspråkig miljö. Dessa barn får problem i förskolan och ofta senare under skolåren efterLanguage Processing and Contextual Influence A Study of Swedish Preschool Children with Language Impairment The aim of the present work was to study different types of contextual influence on language performance in a variety of tasks: repetition of nonwords, narration, understanding of idioms and picture naming in a group of Swedish preschool children with language impairment (LI). The stress p

The aim of this paper is to present the software development techniques used to build the EIS Patterns development framework, which is a testbed for a series of techniques that aim at giving more flexibility to EIS in general. Some of these techniques are customizations or extensions of practices created by the agile software development movement, while others represent new proposals. This paper a

This article outlines how conceptual spaces theory applies to modeling changes of scientific frameworks when these are treated as spatial structures rather than as linguistic entities. The theory is briefly introduced and five types of changes are presented. It is then contrasted with Michael Friedman’s neo-Kantian account that seeks to render Kuhn’s “paradigm shift” as a communicatively rational

The recent progress in our work to implement salt (NaCl) as a dosemeter is presented. Laboratory investigations have indicated a linear dose response from 1 mGy to about 100 mGy and detection limits down to 0.1 mGy. Investigations in the clinic comparing TL-dosimetry in LiF and OSL in NaCl have indicated a similar dose response for the two dosemeters at different photon energies. Field studies wit