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Ribonucleotide reductases (RNRs) are important enzymes that convert the building blocks of RNA (NTPs) into building blocks of DNA (dNTPs). dNTPs are used for synthesis of DNA as well as repair of mutated and damaged DNA. These cellular processes are critical to an organism. That is why these processes are found in various organisms. Since these processes are so essential, their allosteric regulati
Artificial neural networks is a powerful tool for classifying and identifying patterns in large amounts of data. One of the possible tasks of these networks is classification of data into categories. LDMX is a fixed target experiment that is designed to search for light dark matter particles using missing energy and momentum of electrons passing through and scattering of a target. In the current d
Detta examensarbete har utförts i syfte att jämföra hur fyra olika databashanterare (DBMS) presterar inom ett begränsat antal områden för att därigenom dra slutsatser kring vilken som fungerar bäst för att lagra data om rabatter på IKEA. De databashanterare som testas är MongoDB, MariaDB, Neo4j och PostgreSQL. För att åstadkomma en jämförelse utfördes en form av testning - en benchmark. BenchmarkeThis thesis has been conducted in order to compare how four different database management systems (DBMSs) perform in a limited number of areas, in order to draw conclusions about which one works best for storing discount data at IKEA. The DBMSs being evaluated are MongoDB, MariaDB, Neo4j and PostgreSQL. To enable a comparison, a form of testing was performed - a benchmark. The benchmarking consist
This study was done due to observed differences during production, involving the active pharmaceutical ingredient mesalazine, obtained from different suppliers. The aim of the present thesis was to make an investigation of previously not specified properties of mesalazine. This was done to enable adjustment of different parameters during production to account for differences in the raw material.
Exoplanet surveys have identified a category of giant planets that orbit very close to their host stars - the so-called hot Jupiters. The origin of such hot Jupiters is a long standing puzzle and has been closely investigated since the first discovery of such planets in 1995. The two competing formation paths suggests that they either migrated inwards during their formation process, through gravit
Pinus sylvestris (tall) är en betydelsefull trädart i Sverige och Europa, både ekonomiskt och kulturellt sett. Trädet infekteras dock av den destruktiva rottickan (Heterobasidion spp.) vilket resulterar i stora ekonomiska förluster inom skogsindustrin, med en uppskattad monetär förlust på ca 800 miljoner EUR årligen i Europa. Det är svårt att upptäcka svampen i tidiga infektionsstadier eftersom inPinus sylvestris (Scots pine) is an important tree species in Sweden and Europe, both economically and culturally. However, the highly destructive root rot fungi Heterobasidion spp. infect P. sylvestris and cause major economic losses in the forest industry, estimated to about 800 million EUR annually in Europe alone. Detection of the fungus in early stages is hard, as the infection mainly stays i
Denna uppsats behandlar det svenska granskningssystemet för utländska direktinvesteringar, etablerat genom lag (2023:560) om granskning av utländska direktinvesteringar. Uppsatsen fokuserar på förhållandet mellan en långtgående anmälningsplikt och det begränsade antal ärenden där granskningsmyndigheten inleder en materiell granskning eller vidtar ingripande åtgärder. Sedan lagens ikraftträdande hThis thesis examines the Swedish system for screening foreign direct investments, introduced through the Screening of Foreign Direct Investments Act (2023:560). Focus lies on the relationship between the extensive duty to notify investments and the comparatively limited number of cases in which the competent authority initiates a substantive review or adopts restrictive measures. Since the sc
The Käppala WWTP data is modelled by using WEST software to evaluate how the storm water affects the treatment plant process and to use the flow data from Ryaverket WWTP to the Käppala WWTP model in order to model. The flow estimation method which gives best results for the flow data over a long period on the low flow occurrence is 95 percentile flow estimation method. This method was used to dete
This report aims to examine the economic conditions of photovoltaic systems in sports halls. It also intends to examine if it is economically viable to use the excess production from the solar electricity to heat up a hot water storage tank instead of selling it into the grid. This will be answered by studying Knislinge sports hall. Two different configurations of the solar system were investigat
The “peer to peer” (P2P) is a technology of downloading and filesharing between online - Internet - users by the mean of specified software. Since June 1999, the Napster software has made the happiness of millions of individuals who used it to obtain and share free audio files Mp3. Rapidly, the major recording companies have prosecuted the Napster Company and managed to force it to close down. The
Characterizing ore deposits or mining dumps in terms of mineral content and grain size remains a challenge. Since the 1950s the induced polarization (IP) method has been successfully applied in ore prospecting. However, reliably interpreting field survey data requires comprehensive laboratory studies to establish a link between the IP parameters from empirical or phenomenological models and the ty
An innovative coaxial dual-swirl combustor was developed to address the challenges of combustion instability and NOx emissions inherent to ammonia combustion. The combustor employs an inner swirler supplying a premixed ammonia/air stream and an outer swirler generating a premixed methane/air flame that stabilizes the inner ammonia flame. Combined large-eddy simulations (LES) and planar laser-induc
While a naive algorithm for multiplying two 2 × 2 matrices requires eight multiplications and four additions, Strassen showed how to compute the same matrix product using seven multiplications and 18 additions. Winograd reduced the number of additions to 15, which was assumed to be optimal. However, by introducing a change of basis, Karstadt and Schwartz showed how to lower the number of additions
Large volumes of data from satellite sensors with high time-resolution exist today, e.g. Advanced Very High Resolution Radiometer (AVHRR) and Moderate Resolution Imaging Spectroradiometer (MODIS), calling for efficient data processing methods. TIMESAT is a free software package for processing satellite time-series data in order to investigate problems related to global change and monitoring of veg
Objective. To describe the change of pain reports over time in 3 cohorts derived from the general population: (1) no chronic pain (NCP, n = 1156); (2) chronic regional pain (CRP n = 502) and (3) chronic widespread pain (CWP; n = 242). To identify risk factors that predict the development or persistence of chronic widespread pain. Methods. A 3-year followup from 1995 to 1998 with postal questionnai
A total of 3,016 malignant solid tumors (kidney, colorectal, breast, head and neck, ovarian, and lung carcinomas, neuroglial tumors, malignant melanoma, and testicular germ cell tumors) were selected for statistical analyses regarding karyotypic evolution. Genomic imbalances, i.e., net gains and losses, present in more than 5% of each tumor type were identified. Individual tumors were then classif
Laser Doppler velocimetry (LDV) measurement and large eddy simulation (LES) were used to study confined isothermal turbulent swirling flows in a model dump combustor. The aim was to gain deeper understanding of the flow and turbulence structures in dump combustors and to examine the capability of LES for prediction of turbulent swirling flows. A refractive index matching technique is used in the L
A method of removing radiolabeled monoclonal antibodies (mAbs) from blood using a device external to the body, termed extracorporeal affinity-adsorption (EAA), is being evaluated as a means of decreasing irradiation of noncancerous tissues in therapy protocols. The EAA device uses an avidin column to capture biotinylated-radiolabeled mAbs from circulated blood. In this investigation, three trifunc
Objective: In this study, our aim was to investigate how different immunohistochemical techniques may influence the result of BCL6 positivity and categorization in germinal center (GC) and non-GC derived diffuse large B-cell lymphoma (DLBCL), as it has been proposed that classification of DLBCL according to cell-of-origin by immunohistochemistry may be performed as a routine procedure in the diagn
