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INTRODUCTION: Hip and knee osteoarthritis is a leading cause of disability worldwide. Currently, the course of deterioration in pain and physical functioning in individuals with osteoarthritis is difficult to predict. Factors such as socioeconomic status and comorbidity contribute to progression of osteoarthritis, but clear associations have not been established. There is a need for early identifi
Among the existing estimators of interactive effects (IEs) regressions, the common correlated effects (CCE) approach is probably the most popular. A major reason for this popularity is the generality of the approach. In fact, CCE is remarkably general in that it allows ample parameter heterogeneity without placing any restrictions on the true number of common factors. In the present paper, we show
Isothermal titration calorimetry (ITC) is an apt tool for a total thermodynamic description of self-assembly of atypical amphiphiles such as anionic boron cluster compounds (COSAN) in water. Global fitting of ITC enthalpograms reveals remarkable features that differentiate COSAN from classical amphiphiles: (i) strong enthalpy and weak entropy contribution to the free energy of aggregation, (ii) lo
The atrioventricular (AV) node plays an important role during atrial fibrillation (AF). In particular, the refractoriness of its cells influences the conduction of atrial impulses to the ventricles and, thus, the ventricular response. This study introduces a novel statistical model of the AV node, accounting for pathway switching, which can be used for non-invasive assessment of the refractory pro
Objective: The atrioventricular (AV) node plays a central role in atrial fibrillation (AF) as it influences the conduction of impulses from the atria into the ventricles. In the present paper, the statistical dual pathway AV node model, previously introduced by us, is modified so that it accounts for atrial impulse pathway switching even if the preceding impulse did not cause a ventricular activat
This presentation contributes new perspectives to media scandals – a field where both moral and media transgressions are exposed – and illuminates the personal experience of being at the centre of such an event. By using phenomenological and anthropological perspectives upon an extensive empirical material to focus on how the scandal is experienced by the person at the centre of the scandal, the e
Drawing on ethnographical work at the Swedish Public Employment Service, this article contextualizes functional stupidity in relation to other types of organizational compliance. Rather than seeing stupidity as a personality trait, I argue that it should be regarded as a transient unreflective mode of compliance one may yield to for a number of reasons but also reflect on in hindsight. Based on th
This chapter introduces an ancient perspective on literary style and applies it to parts of the Fourth Gospel. Rather than using stylistic features to indicate authorship, sources, or redaction, this chapter focuses upon how style affects how the content (and story) of the Fourth Gospel is understood. In antiquity, stylistic features conveyed information about the mood, focus, and interpretation o
Simple models are less input demanding and their calibration involves a lower number of parameters, however their general applicability to vast areas must be tested. We analysed if a simple ecosystem model (PRELES) can be applied to estimate carbon and water fluxes of Boreal forests at regional scale. Multi-site (M-S) and site-specific (S-S) calibrations were compared using evapotranspiration (ET)
Nanoscale plasmonic systems combine the advantages of optical frequencies with those of small spatial scales, circumventing the limitations of conventional photonic systems by exploiting the strong field confinement of surface plasmons. As a result of this miniaturization to the nanoscale, electron microscopy techniques are the natural investigative methods of choice. Recent years have seen the de
In the science education research field there is a large body of literature on the 'nature of science' (NOS). NOS captures issues about what characterizes the research process as well as the scientific knowledge. Here we, in line with a broad body of literature, use a wide definition of NOS including also e.g. socio-cultural aspects. It is argued that NOS issues, for a number of reasons, should be
Monitoring the aquatic environment and the life of free-floating organisms remains on the borderline of our technical capabilities. Therefore, our insights into aquatic habitats, such as, abundance and behavior of organisms are limited. In order to improve our understanding of aquatic life, we have developed a low-cost inelastic hyperspectral lidar with unlimited focal depth and enough sensitivity
This contribution reviews theory, algorithms, and validation results for system identification of continuous-time models from finite non-uniformly sampled input-output sequences. The algorithms developed are autoregressive methods, and methods of stochastic realization adapted to the continuous-time context. The resulting model can be decomposed into an input-output model and a stochastic innovati
Dion–Jacobson (DJ) type 2D perovskites with a single organic cation layer exhibit a narrower distance between two adjacent inorganic layers compared to the corresponding Ruddlesden–Popper perovskites, which facilitates interlayer charge transport. However, the internal crystal structures in 2D DJ perovskites remain elusive. Herein, in a p-xylylenediamine (PDMA)-based DJ perovskite bearing bifuncti
Food accessibility has been an important issue for as long as there has been human civilisation. Today, food, at least in the wealthier parts of the world, is accessible to most people. However, there are concerns regarding the market power of major retailers and the availability of affordable food among certain population groups. In this paper, I investigate how well accessibility, the ease with
The process of protein crystallization from aqueous protein solutions is still insufficiently understood. During macroscopic crystal formation, occurring often on time scales from a few hours to several days, protein dynamics evolves on the molecular level. Here, we present a proof of concept and a framework to observe this evolving diffusive dynamics on the pico- to nanosecond time scale, associa
Since humans' activities contribute to climate change it is important to change behavior. Switching to a hybrid/plugin/electric vehicle (HEV/PHEV/EV) for personal transport can be one way. In this study the intention to switch to a HEV/PHEV/EV is studied from the theoretical framework of the moral norm-activation theory of altruism (Schwartz, 1977) and the Value-Belief-Norm (VBN) Theory of environ
Somatic rearrangements contribute to the mutagenized landscape of cancer genomes. Here, we systematically interrogated rearrangements in 560 breast cancers by using a piecewise constant fitting approach. We identified 33 hotspots of large (>100 kb) tandem duplications, a mutational signature associated with homologous-recombination-repair deficiency. Notably, these tandem-duplication hotspots were
The W and Z boson production was measured via the muonic decay channel in proton-lead collisions at sNN=5.02 TeV at the Large Hadron Collider with the ALICE detector. The measurement covers backward (−4.46 < ycms < −2.96) and forward (2.03 < ycms < 3.53) rapidity regions, corresponding to Pb-going and p-going directions, respectively. The Z-boson production cross section, with dimuon invariant mas
