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Adipose tissue plays a major role in regulating whole-body insulin sensitivity and energy metabolism. To accommodate surplus energy, the tissue rapidly expands by increasing adipose cell size (hypertrophy) and cell number (hyperplasia). Previous studies have shown that enlarged, hypertrophic adipocytes are less responsive to insulin, and that adipocyte size could serve as a predictor for the devel

BACKGROUND: Patients with platinum-sensitive recurrent ovarian cancer are a heterogeneous group, and it is not possible to accurately predict the progression-free survival (PFS) in these patients. We developed and validated a nomogram to help improve prediction of PFS in patients treated with platinum-based chemotherapy.METHODS: The nomogram was developed in a training cohort (n=955) from the CALY

In Salix myrsinifolia-phylicifolia, males and females produced approximately the same number of catkins per individual, but males produced more flowers per catkin. Females had a higher concentration of sugars in the nectar than males, but the standing crop of nectar did not differ between sexes. Females had a hexoserich nectar, males a sucrose-dominated nectar. Bumblebees discriminated between mal

Electrical quantum conductors coupled to microwave resonators have in the last decade emerged as a versatile test bed for controllable light-matter interaction on the nanometer scale. Recent experimental progress with high-impedance resonators has resulted in conductor-resonator systems with a large, dimensionless coupling parameter λ 0.1, well beyond the small-coupling regime, λ1 Motivated by thi

Confinement or geometric frustration is known to alter the structure of soft matter, including copolymeric melts, and can consequently be used to tune structure and properties. Here we investigate the self-assembly of ABC and ABB 3-miktoarm star copolymers confined to a spherical shell using coarse-grained dissipative particle dynamics simulations. In bulk and flat geometries the ABC stars form he

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that

Regression testing is a means to assure that a change in the software, or its execution environment, does not introduce new defects. It involves the expensive undertaking of rerunning test cases. Several techniques have been proposed to reduce the number of test cases to execute in regression testing, however, there is no research on how to assess industrial relevance and applicability of such tec

Bryophytes play key roles in the ecological function of a number of major world biomes but remain understudied compared with vascular plants. Little is known about bryophyte responses to different aspects of predicted changes in moisture dynamics with climate change. In this study, CO

This article deals with an essential problem in the metal cutting industry, the problem of predicting tool wear and tool life. This is also a problem that has been studied by academia for the last century, often with very little added knowledge. The possibility to replace a large number of systematic wear tests with only a few specially designed

A large strand of research holds that democracy with its broad representation and electoral accountability is beneficial for the provision of public goods. Yet, there is a large variation in how democracies perform, indicating that democratic institutions alone do not suffice for securing citizens’ wellbeing. Recent studies have stressed the equal importance of state capacity for public goods deli

Stakeholder interaction is important for enabling environmental research to support the societal transition to sustainability. We argue that it is crucial to take researchers’ approaches to and perceptions of stakeholder interaction into account, to enable more clarity in discussions about interaction, as well as more systematic interaction approaches. Through a survey and focus group interviews w

The construction, operation and maintenance of transportation infrastructure require energy and materials which impact the environment. Large infrastructure projects thus use resources intensively and leave a significant environmental footprint. To demonstrate and support the sustainability of such large-scale projects, life cycle assessment (LCA) has become a common tool to evaluate environmental

The Cherenkov Telescope Array (CTA), will be the major global observatoryfor very high-energy (VHE) gamma-ray astronomy over the next decadeand beyond. The scientific potential of CTA is extremely broad: fromunderstanding the role of relativistic cosmic particles to the search for darkmatter. CTA is an explorer of the extreme universe, probing environmentsfrom the immediate neighbourhood of black

Poststroke recovery requires multiple repair mechanisms, including vascular remodeling and blood-brain barrier (BBB) restoration. Brain pericytes are essential for BBB repair and angiogenesis after stroke, but they also give rise to scar-forming platelet-derived growth factor receptor β (PDGFR-β)–expressing cells. However, many of the molecular mechanisms underlying this pericyte response after st

Dolphin echolocation clicks measured far off-axis contain two time-separated components. Whether these components overlap and appear as a single signal on axis has received little attention. Here, the scaled reassigned spectrogram analysis was used to examine if bottlenose dolphin (Tursiops truncatus) clicks measured near- or on-axis of the echolocation beam contained overlapping components. Acros

Summary. Breast cancer in women under 30 years old carries a poor prognosis, for reasons that have not been identified. This study aimed to identify prognostic factors in this age group. Special attention was paid to the history of pregnancy. The clinical presentation and course of breast cancer was documented for 407 women, aged 20-29 years, who registered between 1978 and 1988 at one of nine can

Background. If several risk factors for disease are considered in a regression model and these factors are affected by measurement errors, the observed relative risk will be attenuated. In nutritional epidemiology, several nutrient variables show strong correlation, described as collinearity. The observed relative risk will then depend not only on the validity of the chosen diet assessment method