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Detta arbete handlar om en behandlingsteknik för hudterapi där lågenergetiska elektroner utnyttjas för strålbehandling där patienten står eller sitter på en roterande plattform. För att behandlingen skall få ett lyckat resultat krävs en viss stråldos (den absorberade energin per massenhet) till patientens hud. För att kontrollera att dosen är rätt används normalt mätningar med olika detektorer. DeBackground and purpose: This study refers to a rotational radiotherapy technique for the treatment of mycosis fungoides. Patients are irradiated by a high dose-rate low-energy electron beam while they stand on a rotating platform. This report presents a first effort to use the Geant4 simulation program to calculate the relation between the stationary and rotational depth dose distributions in an e

Global climate projections forecast more frequent, intense and longer heat waves in the decades ahead. Heat waves are considered the most dangerous extreme weather event for human health, with impacts most pronounced in cities because of the urban heat island effect. Heat-related mortality rates are highest in certain at-risk populations, like the elderly. Toronto, Canada’s largest city, faces two

What level of influence should market actors be allowed to exert over consumers’ transactional decisions? While persuasive marketing is inherent to free markets and therefore uncontroversial, relatively recent research in the field of behavioural economics about systemic errors in human decision-making has shown just how susceptible consumers are to the will of market actors. Within a rapidly evol

De senaste åren har den organiserade brottslighet i Sverige ökat markant. Landet pekas ut som skräckexempel i världen och antalet skjutningar och sprängningar ökar år för år. Samtidigt finns en utbredd tystnadskultur där allt färre svenskar vågar vittna mot den tilltalade vid ett misstänkt brott på grund av rädsla för hot och repressalier. Mot bakgrund av den otrygghet många känner i dagens samhälIn recent years, organized crime in Sweden has grown significantly. The country is pointed out as a warning example in the world, while the number of shootings and explosions increases year by year. At the same time, there is a widespread culture of silence due to which many witnesses do not dare to testify against the accused in the event of a suspected crime, partly out of a strong fear of threa

Achievement of sustainability goals is an epic task for developing economies that still strive to fulfil their basic needs. The availability of limited resources in the developing world vis-à-vis the ever-increasing demand poses further challenges to developing economies willing to transition into circular economies. Reverse logistics (RL) can facilitate this transition towards a circular economy

Enzymes, as efficient and environmentally friendly catalysts, have gainedsignificant scientific and industrial attention for their mild operating conditions,high substrate selectivity and reusability when immobilized. Among them, lipasesdominate the global industrial enzyme market, catalyzing various reactions with afocus on substrate specificity and selectivity. This thesis investigates theoptimi

The 4MOST consortium is currently halfway through a Conceptual Design study for ESO with the aim to develop a wide-field (>3 square degree, goal >5 square degree), high-multiplex (>1500 fibres, goal 3000 fibres) spectroscopic survey facility for an ESO 4m-class telescope (VISTA). 4MOST will run permanently on the telescope to perform a 5 year public survey yielding more than 20 million spectra at

Understanding how ecological communities assemble in relation to natural and human-induced environmental changes is critical, particularly for communities of pollinators that deliver essential ecosystem services. Despite widespread attention to interactions between functional traits and community responses to environmental changes, the importance of sensory traits has received little attention. To

The order Picornavirales includes viruses that infect different kinds of eukaryotes and that share similar properties. The capsid proteins (CPs) of viruses in the order that infect unicellular organisms, such as algae, presumably possess certain characteristics that have changed little over the course of evolution, and thus these viruses may resemble the Picornavirales ancestor in some respects. H

BACKGROUND: Previous studies of glucagon stimulation test (GST) in children have shown variable results regarding the utility and reliability of the cortisol response to this test and its correlation with clinical parameters. The aim of this study was to assess cortisol levels at GST and to evaluate how clinical parameters, such as age, sex, pubertal status and Body Mass Index (BMI), correlate to

Purpose: Radiation therapy (RT) causes tissue damage and inflammation. Because cytokines play a key role in such processes, their expression levels can be an indicator of cell and tissue toxicity. This critical review aims to explore whether levels of circulating inflammatory biomarkers in peripheral blood are associated with proton- or photon-based therapy in the pelvic area and how these levels

Background/Objectives: There is still no consensus as to whether patients with upfront resectable synchronous colorectal liver metastases (sCRLM) should receive neoadjuvant treatment prior to liver surgery. Two randomized controlled trials have assessed the role of peri-operative chemotherapy in sCRLM; neither have shown a survival benefit in the neoadjuvant group. The aim of this population-based

Background Obesity is increasing among patients with inflammatory bowel disease, but bariatric surgery has been rare in this group owing to concerns about worsening the inflammatory bowel disease. The aim of the study was to evaluate inflammatory bowel disease-related outcomes following bariatric surgery. Methods Nationwide cohort of all adult patients in Sweden between 2007 and 2020 with obesity

Exposure to extreme temperatures can negatively affect animal reproduction, by disrupting the ability of individuals to produce any offspring (fertility), or the number of offspring produced by fertile individuals (fecundity). This has important ecological consequences, because reproduction is the ultimate measure of population fitness: a reduction in reproductive output lowers the population grow

OBJECTIVE: The authors sought to clarify the components of the familial liability to alcohol use disorder (AUD) by examining parent-offspring transmission in a large Swedish population sample. METHODS: To this end, 1,244,516 offspring in intact families with a mean age at follow-up of 37.7 years (SD=6.8) were examined. Hazard ratios for offspring of parents with AUD were calculated using Cox model

BACKGROUND: There are important unmet clinical needs to develop cell enrichment technologies to enable unbiased label-free isolation of both single cell and clusters of circulating tumor cells (CTCs) manifesting heterogeneous lineage specificity. Here, we report a pilot study based on the microfluidic acoustophoresis enrichment of CTCs using the CellSearch CTC assay as a reference modality.METHODS

BACKGROUND: Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel.METHODS: In this double-blind, 2-by-2 factorial trial, we randomly assigned patients to receive 25 mg of aspirin plus 200 mg of extended-release dipyridamole twice daily

Introduction: With a rapidly ageing population, the number of distal radius fractures (DRFs) in the elderly will increase dramatically. The aim of this retrospective register study was to examine the 1- and 5-year mortality in DRF patients aged 80 years or more and correlate the overall survival to factors not related to the fracture itself. Material and Methods: Patients aged ≥80 diagnosed with D

Objective: This study aimed to report the initial experience with a novel bidirectional double cuff inner branch design for incorporation of renal and mesenteric arteries in patients undergoing fenestrated and branched endovascular aortic repair (F/BEVAR). Methods: A retrospective review was undertaken of the experience of F/BEVAR with grafts integrating at least one bidirectional double cuffed in

Background: Low grip strength and gait speed are associated with mortality. However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited. Aim: We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors. Methods: Participants from the Heal