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Acute myeloid leukemia (AML) is a highly heterogeneous blood disease which is characterized by different mutations and chromosomal rearrangements. Nearly 60% of genetic alterations have been found in AML patients involve in signaling pathways including signaling of tyrosine kinase receptor FLT3. FLT3 mutations emerged as one of the most common mutations in AML which represent around 35% of all AML
Inflammatory airway diseases and lower respiratory tract infections are leading causes of severe illness, disability and death worldwide. Much of today´s hypotheses about the underlying inflammatory processes and pathogenic contribution by immune cells come from in vitro experiments or animal models. As a consequence, our knowledge of the actual immunopathological events in real patient tissues is
Background: In prostate cancer (PCa), questions remain on indications for prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging and PSMA radioligand therapy, integration of advanced imaging in nomogram-based decision-making, dosimetry, and development of new theranostic applications. Objective: We aimed to critically review developments in molecular hybrid imaging an
The number of users and the information transmitted over wireless networks have been growing constantly during the last decades. Nowadays, the pace of this growth is extremely sharp because of the new applications which heavily rely on wireless networks to meet users' demands. Wireless networks infrastructures are constantly developing to meet these demands. Massive multiple-input multiple-output
Land cover governs biogeophysical and biogeochemical feedbacks between the land surface and atmosphere. Holocene vegetation-atmosphere interactions are of particular interest, both to understand the climate effects of intensifying human land use and as a possible explanation for the Holocene Conundrum, a widely studied mismatch between simulated and reconstructed temperatures. Progress addressing
Phosphorus (P) is a critical macronutrient for plant growth, often limiting plant production in areas where plant demand is higher than soil supply. In contrast to nitrogen (N), P cannot be sourced from the atmosphere; therefore, where it is rare, it becomes a strong constraint on primary production. Due to this, most dynamic global vegetation models (DGVMs) are incorporating a prognostic P cycle
Northern forest ecosystems make up an important part of the global carbon cycle. Hence, monitoring local-scale gross primary production (GPP) of northern forest is essential for understanding climatic change impacts on terrestrial carbon sequestration and for assessing and planning management practices. Here we evaluate and compare four methods for estimating GPP using Sentinel-2 data in order to
Historically, aerosols of anthropogenic origin have offset some of the warming from increased atmospheric greenhouse gas concentrations. The strength of this negative aerosol forcing, however, is highly uncertain-especially the part originating from cloud-aerosol interactions. An important part of this uncertainty originates from our lack of knowledge about pre-industrial aerosols and how many of
Background: Subjective Well-Being (SWB) is usually conceptualized in terms of an affective (i.e., judgements of biological emotional reactions and experiences) and a cognitive component (i.e., judgements of life satisfaction in relation to a psychological self-imposed ideal). Recently, researchers have suggested that judgements of harmony in life can replace or at least complement the cognitive co
In this thesis, we investigate and develop new methods for efficient and functional use of resources in edge networks. Setting this work aside from previous work, we study User Generated Content (UGC) such as social media information and data generated in the new emerging Internet of Things systems. We present efficient solutions for placing such content and managing which network resources should
In the domain of current spatial semiotics two important, but also radically different, approaches can be distinguished as modelling the co-operative agency of human, material and legal properties of space, namely that of Manar Hammad’s and that of Bruno Latour’s. Hammad, being a semiotician, more true to the Greimasian heritage, regards a finite set of principal actantial types (owners, visitors,
The tumor microenvironment consists of several interacting cell types. Cancer research focssed mainly on the malignant cell in the past. The importance of the tumor microenvironment is increasingly appreciated, as endothelial cells and immune cells were identified as targets for anti-tumor therapy. Targeted therapy against cancer-associated fibroblasts (CAFs) are not in clinical use for the treatm
Land-use and land-cover (LUC) changes are a key uncertainty when attributing changes in measured atmospheric CO2 concentration to its sinks and sources and must also be much better understood to determine the possibilities for land-based climate change mitigation, especially in the light of human demand on other land-based resources. On the spatial scale typically used in terrestrial ecosystem mod
B cells are essential cells that are part of the adaptive immune system with the capacity to produce antibodies against exogenous antigens. These cells are produced through a process called hematopoiesis, tightly regulated by extrinsic and intrinsic factors. Among these, tyrosine kinase receptors and their cytokines have been shown to have an important role in adult lymphopoiesis regulation. Howev
Popular Abstract in Swedish Industrin i Sverige och i många andra länder står för en stor del av samhällets energianvändning och energi utgör en nödvändig insats i industrins processer och förädling av produkter. Industriell tillverkning sysselsätter dessutom många arbetstagare både direkt och indirekt i utbytet med övriga delar av samhället och ekonomin. Samtidigt medför energianvändning och relaAt EU and to a varying degree at Member State (MS) level, industrial energy efficiency improvement (EEI) is considered an attractive means for reaching political objectives of different dimensions, not least environmental. For energy-intensive manufacturing industry in particular, EEI can lead to cost reductions, improved profitability and competitiveness. However, research and other analyses show
The thesis comprises an analysis of the heat transfer phenomenon in solid oxide fuel cells (SOFCs) and a description of various transport phenomena in a solid oxide electrolysis cell. Both devices are encompassed under the solid oxide electrochemical cell concept. Moreover, a CFD model of an SOEC was developed to study the behavior of the cell under different conditions of operating and structural
Pollen analyses and AMS C-14 measurements were performed on lacustrine sediments and peat sequences from two former crater lakes (Preluca Tiganului, Steregoiu) situated in the Gutaiului Mountains in northwestern Romania, in order to reconstruct the vegetation development during the Lateglacial and Early Holocene. Before c. 14,700 cal. years BP (GS-2) open vegetation with shrubs (Salix, Juniperus),
Popular Abstract in Swedish Avhandlingen undersöker de två behandlingsalternativ, hemodialys och njurtransplantation, som är tillgängliga för personer med njursvikt. I fokus för undersökningen står de former av person- och patientskap som skapas och upprätthålls i hemodialys- och njurtransplantationsvården samt i de njursjukas vardagsliv. Ett av avhandlingens grundläggande antaganden är att dessa This thesis examines the practice of haemodialysis and kidney transplantation, the two medical therapies available for persons with kidney failure, from a phenomenological perspective. A basic assumption made in the thesis is that contemporary biomedicine is deeply embedded in the cultural, historical, economic, and political circumstances provided by the particular local, national, and transnatio
This thesis presents methods for improving the accuracy and efficiency of tasks performed using different kinds of industrial manipulators, with a focus on the application of machining. Industrial robots offer a flexible and cost-efficient alternative to machine tools for machining, but cannot achieve as high accuracy out of the box. This is mainly caused by non-ideal properties in the robot joint
