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Anti-amyloid treatments for early symptomatic Alzheimer disease have recently become clinically available in some countries, which has greatly increased the need for biomarker confirmation of amyloid pathology. Blood biomarker (BBM) tests for amyloid pathology are more acceptable, accessible and scalable than amyloid PET or cerebrospinal fluid (CSF) tests, but have highly variable levels of perfor

Digital breast tomosynthesis (DBT) has become a standard screening tool for breast cancer. However, its diagnostic performance is still limited compared to contrast-enhanced MRI, especially in women with dense breasts. Ultrafast dynamic contrast-enhanced (UF DCE) MRI and diffusion-weighted imaging (DWI) offer a shorter scanning time than conventional MRI and have shown promise in previous studies.

Background: Studies have shown that the effectiveness of virtual reality (VR) can be improved by using learning prompts (e.g., summary prompts, pretraining, and priming). However, less is known about how such learning prompts affect students’ processing of the learning content within the virtual learning environment. Aims: This study aimed to shed light on students’ processing of learning content

This study presents the results from a set of 11 large-scale open fire tests performed on flexible polyurethane foam slabs/mattresses. The purpose of the study was to investigate the influence of the ignition location on the fire behaviour of the foam slabs and to generate data on a highly characterised material that could be used for modelling work in the future. A method for obtaining spatially

Water security, a key policy objective for sustainable development, is under stress as a result of land use and climate change, especially in (semi-)arid areas like Iran. Land use change alters surface runoff and affects basin-wide hydrological processes and water consumption, while climate change modifies precipitation and temperature patterns and consequently evapotranspiration and water supply.

Background: Geant4 is a Monte Carlo code extensively used in medical physics for a wide range of applications, such as dosimetry, micro- and nanodosimetry, imaging, radiation protection, and nuclear medicine. Geant4 is continuously evolving, so it is crucial to have a system that benchmarks this Monte Carlo code for medical physics against reference data and to perform regression testing. Aims: To

Background: Chronic widespread pain (CWP) has a negative impact on health status, but results have varied regarding gender-related differences and reported health status. The aim was to study the impact of CWP on health status in women and men aged 35-54 years in a sample of the general population. The aim was further to investigate lifestyle-related predictors of better health status in those wit

Background: ICU prognostication is difficult because of patients’ prior comorbidities and their varied reasons for admission. The model used for ICU prognostication in Sweden is the Simplified Acute Physiology Score 3 (SAPS 3), which uses information gathered within one hour of ICU admission to predict 30-day mortality. Since the SAPS 3 model was introduced, no biomarkers have been added to it to

The notion of ‘post-truth’ has attracted considerable interest both in academic and political circles, as well as in public debate more generally. A ‘post-truth society’ has been defined as a society in which ‘“objective facts” are less influential in shaping public opinion than appeals to emotion and personal belief’. This also implies a society in which fake news is disseminated on purpose and w

Fruit-feeding pteropodid bats roost under varying light conditions. Some roost in trees with high exposure to daylight (> 1000 lx), while others roost in dark caves (< 0.1 lx). To understand the effect of ambient light intensity and moon phase on flight activity, we examined flight times across five lunar cycles in three pteropodid species whose roosts differ in daylight exposure. We found signifi

CONTEXT: The complexity of bladder cancer diagnosis and staging results in delays in definitive treatment of muscle-invasive bladder cancer by radical cystectomy. OBJECTIVE: This systematic review and meta-analyses aim to assess the impact of delays in radical cystectomy. EVIDENCE ACQUISITION: A systematic review was conducted by searching Medline and Ovid Gateway using protocol-driven search term

Statoil has implemented a structured approach for assessing the condition of the safety barriers on their processing facilities as a key measure to control and reduce major accident risk. The TTS (Teknisk Tilstand Sikkerhet, Norwegian for technical condition safety) methodology is developed with a strong focus on assessing the actual conditions of the technical safety barriers in place to manage m

Extracellular matrix metalloproteinases (MMPs) are a group of proteins that activate substrates by enzymatic cleavage and, on the basis of their activities, have been demonstrated to play a role in ageing. Thus, in order to gain insight into the pathophysiology of ageing and to identify new markers of longevity, we analysed the activity levels of MMP-2 and MMP-9 in association with some relevant h

Floral plantings are promoted to foster ecological intensification of agriculture through provisioning of ecosystem services. However, a comprehensive assessment of the effectiveness of different floral plantings, their characteristics and consequences for crop yield is lacking. Here we quantified the impacts of flower strips and hedgerows on pest control (18 studies) and pollination services (17

The expanding energy justice scholarship increasingly discusses the importance of equity concerns in the context of global decarbonization. How to equitably distribute the benefits and burdens of energy systems and ensure an inclusive and socially acceptable change, constitutes vital prerequisites for the transition to a low-carbon society. Energy, in a Northern context, is seen as gender-neutral;

The argument of our third lecture showed that iconicity could only be saved from the critical arguments advanced by Bierman and Goodman by means of introducing a properly structured common sense world. In this lecture, we will first consider to what extent the linguistic model may still be helpful, and in which respects it is misleading. Then the necessary furnishing of the common sense world, whi