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Concentration-based fluid biomarkers represent an informative and cost-effective way to detect and monitor Alzheimer’s disease (AD) pathology. However, non-AD-related interindividual variation in biofluids can also affect biomarker concentrations. Here, we investigated whether normalization of CSF and plasma biomarkers to reference proteins, such as amyloid-β40 (Aβ40) and non-phosphorylated mid-re
This work presents an on-chip memory subsystem envisioned for real-time applications performing Oriented FAST and Rotated Brief (ORB) feature extraction for Simultaneous Localization and Mapping (SLAM) systems. For autonomous navigation of battery-powered devices, feature-based SLAM is a computationally frugal alternative to direct methods. This paper thoroughly analyses ORB multiple memory access
Image quality measures are becoming increasingly important in the field of computer graphics. For example, there is currently a major focus on generating photorealistic images in real time by combining path tracing with denoising, for which such quality assessment is integral. We present FLIP, which is a difference evaluator with a particular focus on the differences between rendered images and co
BACKGROUND: Continuous epidural infusions of local anaesthetics have become increasingly popular in postoperative pain treatment, especially as they permit early mobilisation. Ropivacaine is a promising new agent which induces more pronounced sensory than motor blockade. This study was focused on the influence of continuous epidural infusion of ropivacaine on impulse conduction in large nerves (by
The problem of designing robust and noise-insensitive PI controllers for pressure-sensor based combustion-timing control was studied through simulation. Different primary reference fuels (PRF) and operating conditions were studied. The simulations were done using a physics-based, control-oriented model with an empirical ignition-delay correlation. It was found that the controllable region, in-betwThe problem of designing robust and noise-insensitive PI controllers for pressure-sensor based combustion-timing control was studied through simulation. Different primary reference fuels (PRF) and operating conditions were studied. The simulations were done using a physics-based, control-oriented model with an empirical ignition-delay correlation. It was found that the controllable region, in-betw
Our presentation builds on a research project on the emergence of medical genetics and genetic counselling in Sweden 1940-1980. During our study, we have been able to track some aspects of biological, or eugenic, citizenship throughout this period.In Sweden, a rudimentary form of genetic counselling can be tracked within the context of state-controlled eugenics, namely in some applications of the
Partially Premixed Combustion (PPC) is a promising advanced combustion mode for future engines. In order to investigate the sensitivity of PPC to exhaust gas recirculation (EGR) rate, intake gas temperature, intake gas pressure, and injection timing, these parameters were swept individually at three different loads in a single cylinder diesel engine with gasoline-like fuel.A factor of sensitivity
Historian David Lowenthal (1985) has pointed out the past is often perceived and represented as “a foreign country” in which cultural heritage is implicitly understood to be bound to geographical territories and associated notions of what it implies to have roots, an identity, and a place in which to belong. This is the paradigmatic background against which so many heritage museums have been found
Objective. Oxygen (O2) have been a cornerstone in the treatment of acute myocardial infarction. Studies have been inconclusive regarding the cardiovascular and analgesic effects of oxygen in these patients. In the SOCCER trial, we compared the effects of oxygen treatment versus room air in patients with ST-elevation myocardial infarction (STEMI). There was no difference in myocardial salvage index
Background: Dermatitis can impair the quality of life (QoL) of patients. Knowledge of the QoL-associated factors and the impact of patch testing on QoL is limited. Objectives: To identify demographic and clinical factors affecting QoL, and to measure the impact of patch testing on QoL of dermatitis patients. Methods: The data and Dermatology Life Quality Index (DLQI) questionnaires of 519 dermatit
Inthispaper,wedescribeanovelsystemthatidentifiesrelationsbetweentheobjectsextractedfromanimage. We started from the idea that in addition to the geometric and visual properties of the image objects, we could exploit lexical and semantic information from the text accompanying the image. As experimental set up, we gathered a corpus of images from Wikipedia as well as their associated articles. We ex
Ever since the invention of the internal combustion engine, there has been an interest in optimizing the in-cylinder pressure to achieve reliable and efficient work output. With the use of in-cylinder pressure sensors, piezoelectric injector actuation, the possibility of multiple injection events and the increased availability of computation power, cycle-to-cycle, in-cylinder pressure optimization
Modelica allows systems to be described with reuseable components and with a high precision. To be able to use such complex models efficiently, high demands are set on tools that allow the user to extract the information needed from the models in a straight-forward manner. For this purpose, design-of-experiments techniques can be used to systematically analyze the complex models.In this paper, it
Following John Ruggie’s UN mandate (2005-2011) the notion of human rights due diligence (HRDD) has become widely used by policymakers, corporations, NGOs and professionals. The question is whether this HRDD concept, as developed in the UN Guiding Principles (GPs), adequately addresses the deeper causes of human rights infringements in business operations. This article provides a textual and contex
