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Background: Weight gain and hypertension are well known adverse effects of treatment with high-dose glucocorticoids. Objective: To evaluate the effects of 2 years of low-dose glucocorticoid treatment in rheumatoid arthritis (RA). Design: Pooled analysis of 5 randomized controlled trials with 2-year interventions allowing concomitant treatment with disease-modifying antirheumatic drugs. Setting: 12
Background: Existing working heart models for ex vivo functional evaluation of donor hearts often use cardiac afterloads made up of discrete resistive and compliant elements. This approach limits the practicality of independently controlling systolic and diastolic aortic pressure to safely test the heart under multiple loading conditions. We present and investigate a novel afterload concept design
In discussions of Scandinavian democratisation, it is commonplace to argue that long-standing farmer representation in parliament and a lack of feudalism facilitated early democratisation. The present essay questions this interpretation in the Swedish case. It centres on a re-interpretation of farmer politics at the national level from the 1866 two-chamber parliament reform to the alliance between
Geophysical methods are prone to fail in an urban environment as all sources of noise are present in cities. The Fælledparken Park, a large open space area in Copenhagen, Denmark is not an exception. However, an extension of the metro along sections of high variability on the surface of a limestone surface motivated the use of geoelectrics as complement to seismic methods. The site conditions have
BackgroundTime-resolved three-dimensional, three-directional phase-contrast magnetic resonance velocity mapping (4D PC-MRI) is a powerful technique to depict dynamic blood flow patterns in the human body. However, the impact of phase background effects on flow visualizations has not been thoroughly studied previously, and it has not yet been experimentally demonstrated to what degree phase offsets
Brain expression of transferrin (Tf) and transthyretin (TTR) mRNA has been demonstrated in different species, TTR being found only in the choroid plexus. We report here that both these mRNAs are also expressed in the meninges. In vitro studies have shown that Tf secretion by the rat choroid plexus is stimulated by 5-hydroxytryptamine (5-HT) while sympathetic nerves regulate different transport fun
Neuroprotective and possible trophic actions of nicotine were studied in two types of experimental models: (1) one in which the meso-striatal dopamine system was subjected to partial hemitransection, and regional glucose utilization (using 2-[3H]deoxyglucose) and blood flow (using [14C]iodoantipyrine) were measured by computer-assisted quantitative autoradiography based on a double-isotope techniq
Background: Three-dimensional time-resolved (4D) phase-contrast (PC) CMR can visualize and quantify cardiovascular flow but is hampered by long acquisition times. Acceleration with SENSE or k-t BLAST are two possibilities but results on validation are lacking, especially at 3 T. The aim of this study was therefore to validate quantitative in vivo cardiac 4D-acquisitions accelerated with parallel i
Viral vector-mediated gene transfer utilizing adeno-associated viral vectors has recently entered clinical testing as a novel tool for delivery of therapeutic agents to the brain. Clinical trials in Parkinson's disease using adeno-associated viral vector-based gene therapy have shown the safety of the approach. Further efforts in this area will show if gene-based approaches can rival the therapeut
In Huntington's disease (HD), the mutant huntingtin protein is ubiquitously expressed. The disease was considered to be limited to the basal ganglia, but recent studies have suggested a more widespread pathology involving hypothalamic dysfunction. Here we tested the hypothesis that expression of mutant huntingtin in the hypothalamus causes metabolic abnormalities. First, we showed that bacterial a
Previous studies have shown that serotonin neurons play an important role in the induction and maintenance of l-DOPA-induced dyskinesia in animals with lesion of the nigrostriatal dopamine system. Patients with Parkinson's disease that receive transplants of foetal ventral mesencephalic tissue, the graft cell preparation is likely to contain, in addition to dopamine neurons, serotonin neurons that
This research analyses the presence of political personalisation and its role in establishing performed authenticity in political content on TikTok. Despite TikTok being a platform created for entertainment purposes, TikTok has come to play a significant role in political discourse and engagement with politicians Employing a qualitative approach to Multimodal Critical Discourse Analysis, this rese
With the emergence of COVID-19, various industries felt under the pressure from limitations associated with the pandemic and transition to a work-from-home workstyle. Healthcare and Software Development is one of the industries that had to face increased demand for their products and services under severe circumstances. As an interconnection of these spheres,eHealth had to address challenges that
The goal of this thesis was to, from several randomly selected patients with diagnosed malignant and benign tumors, record optimal lambdas and respective Renyi entropies for each lambda, run a basic statistical analysis of the results and see if there is any significant difference between lambdas/Renyi entropies of malignant and benign lesions.\\ The results showed no significant difference.\\ The
Innovation is gospel today. This also means a surge in popularity for the agents behind innovation; innovators. But who are they, exactly? Anecdotal evidence from both recent times and historical settings tend to emphasize remarkable individuals, who more or less alone created amazing things. By utilizing the SWINNO-database of innovations, this thesis examines how empirically prevalent the narrat
This essay explores the critiques of modernity from posthuman and Indigenous perspectives, exploring their convergences and divergences. It argues that both frameworks challenge the anthropocentric and dualistic paradigms that have historically governed Western thought. Posthumanism encourages ontological humility by recognizing the non-dual nature of existence and more-than-human agency, while In
In 2012 physicist Peter W. Higgins formulated a theory about elementary particles that can be created out of nothing. If these particles are exposed to extremely high speeds, friction arises which forces a new particle to form, a so-called Higgs boson. Based on two elementary particles, you can create a new mass; matter which was not there from the beginning. In the media, the Higgs boson was nick
Urbanization has led to a concerning decline in biodiversity within cities, necessitating innovative approaches and greening efforts. This project, named “Wild Growth” is aimed at combating urban biodiversity loss, and increasing pollinator-friendly areas, through the design and development of a flower seed spreader. Inspired by principles of simplicity, accessibility, and sustainability, the see
