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Electrospinning can be used to mimic the architecture of an acellular nerve graft, combining microfibers for guidance, and pores for cellular infiltration. We made electrospun nerve guides, from polycaprolactone (PCL) or poly-L-lactic acid (PLLA), with aligned fibers along the insides of the channels and random fibers around them. We bridged a 10 mm rat sciatic nerve defect with the guides, and, iElectrospinning can be used to mimic the architecture of an acellular nerve graft, combining microfibers for guidance, and pores for cellular infiltration. We made electrospun nerve guides, from polycaprolactone (PCL) or poly-L-lactic acid (PLLA), with aligned fibers along the insides of the channels and random fibers around them. We bridged a 10 mm rat sciatic nerve defect with the guides, and, i

Försäkringskassan's status report from 2023 shows that more and more people in Sweden are taking sick leave as a result of stress-related mental illness. The reasons behind sick leave are often that for a longer period, you have not experienced a balance between the demands placed on you and the resources and opportunities you have had to meet these demands and this ultimately leads to exhaust

Proteomic analysis can reveal substantial information about cells and cell types, including biomarkers that can be used to distinguish subpopulations. Established protocols include manual pipetting steps of cells that are both time consuming and problematic in terms of samples losses. In this study, a new “FACS-into-evotip” protocol for proteomic analysis was evaluated with the goal to automate sa

Networks are central to entrepreneurial activity, particularly in the fashion industry, where access to suppliers, buyers, resources, and legitimacy is highly relationship-dependent. While existing research has extensively examined how entrepreneurs develop and mobilize networks within established relational contexts, less is known about how such contexts are initially accessed by founders without

The aim of this thesis was to investigate the relation between tooth size and dental caries in a medieval material from S:t Clemens cemetery in Lund. Dental caries is one of the most common infectious disease in humankind, both in prehistoric and modern populations. Evidence of caries gives the opportunity to study health and diet in populations. During evolution of humankind, there are evidence o

The aim of this thesis is to examine the role of early life environments for a variety of individual-level health and socioeconomic outcomes in contemporary Sweden. Ever-expanding human lifespans have contributed to the emergence of novel socio-health phenomena confronting contemporary Swedish society. A new research framework has emerged in the last 30 years suggesting that individuals’ ability t

This study takes an in-depth look at sustainable procurement criteria used in the procurement of indirect services. A gap is identified in the literature analysis in the knowledge of sustainable procurement strategies and practice methods for the purchase of services and indirect spend categories. The author uses a case study method to investigate how sustainable procurement of indirect services i

Protein interactions are important in understanding various protein relevant cellular and technological processes.This is a challenging task due to the intrinsically irregular shape and inhomogeneous surface distribution of neutral, charged, hydrophobic amino acid residues. This results inmore or less anisotropic interactions depending on external parameters such assalt and pH. However, a deeper u

Deep brain stimulation is an accepted technique for the treatment of Parkinson's disease. Deep brain stimulation affects the electrical functions of neurons and several explanations are available to describe this treatment modality. Such as depolarization blockade, synaptic inhibition, synaptic depression and stimulation induced modulation of pathological network activity. An electrical impedance

We review the history of floristic studies of the parish of Stenbrohult, southern Sweden, where Carl Linnaeus was born in 1707 and spent his summers until 1728. Unfortunately, Carl Linnaeus never made a list of the wild vascular plants at his birthplace, although he mentioned at least 64 species from the parish of Stenbrohult in various manuscripts and books. However, he said that Stenbrohult was

Abstract in French Au-delà du montage – la rhétorique du cinéma Contrairement à d'autres types d'images plus statiques, le film, avec son fort "effet de réalité", semble résister à une explication inspirée d'un modèle rhétorique. Même du point de vue d'une rhétorique "écologique", telle que la nôtre, qui reconnaît une rupture de normes déjà dans les transformations homogènes, le film peut facilem

The 17 beta-hydroxysteroid dehydrogenase 1 gene (HSD17B1) encodes 17HSD1, which catalyzes the final step of estradiol biosynthesis. Despite the important role of HSD17B1 in hormone metabolism, few epidemiologic studies of HSD17B1 and breast cancer have been conducted. This study includes 5,370 breast cancer cases and 7,480 matched controls from five large cohorts in the Breast and Prostate Cancer

We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expression of mitochondrial or cytosolic FH but not by deletion of Hif1α or Nrf2. Progressive hyperglycem

The orthodox definition of hope suffers from an exclusion problem: it is unable to exclude subjects without hope. In fact, the orthodox definition even allows for despair to be falsely classified as hope. This problem suggests two basic desiderata for a successful analysis of hope; it should solve the exclusion problem, and it should have the resources to explain why, in a given situation, a subje

The orthodox definition of hope suffers from an exclusion problem: it is unable to exclude subjects without hope. In fact, the orthodox definition even allows for despair to be falsely classified as hope. This problem suggests two basic desiderata for a successful analysis of hope: it should solve the exclusion problem, and it should have the resources to explain why, in a given situation, a subje

The Northern high latitudes are warming twice as fast as the global average, and permafrost has become vulnerable to thaw. Changes to the environment during thaw leads to shifts in microbial communities and their associated functions, such as greenhouse gas emissions. Understanding the ecological processes that structure the identity and abundance (i.e., assembly) of pre- and post-thaw communitiesThe Northern high latitudes are warming twice as fast as the global average, and permafrost has become vulnerable to thaw. Changes to the environment during thaw leads to shifts in microbial communities and their associated functions, such as greenhouse gas emissions. Understanding the ecological processes that structure the identity and abundance (i.e., assembly) of pre- and post-thaw communities

Who hasn’t had a close one who suffered from pain, who hasn’t suffered from pain themselves? It might have been chronic pain, it might have been acute pain or something else. For many of us describing pain can be close to impossible. You might not know the right words to use and try to use metaphors to express the pain you are in, to a doctor. Despite being such a common sensation, pain can be sur

To make not only scholarly publications but also the data underlying those publications openly accessible is part of the movement for Open Science. There are several arguments for sharing research data, for example to promote science and collaboration, to make validation of results possible and to reduce redundant data production (Callaghan et al. 2012; Tenopir et al. 2011). Open Data policies are