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PURPOSE: To study the toxicology of rifabutin in the rabbit eye with emphasis on retinal function and histopathology.METHODS: Seven rabbits received a daily dose of rifabutin during 15 months. Six rabbits receiving only the vehicle were used as controls. Repeated standardized full-field electroretinograms (ERG) were assessed. After discontinuing treatment, the rabbits were killed and the cornea, t
This study is one of the first that investigated youth’s response to unwanted Internet experiences, not only for those youth who were bothered or distressed but for all youth who reported the experience. Three types of response were examined: telling someone about the incident and ending the unwanted situation by active or passive coping. Responses to the following unwanted Internet experiences we
Absence or reduced activity of coagulation factor IX (FIX) causes the severe bleeding disorder haemophilia B. FIX contains a Gla module, two epidermal growth factor-like (EGF) modules, and a serine protease region. I characterized a monoclonal antibody and found that it recognizes an epitope around residues 72 and 80 in the C-terminal part of EGF1 in human FIX. The antibody exhibited 10-fold great
Popular Abstract in Danish Ved CERN (Conseil Européen pour la Recherche Nucléaire) accelerer man protoner og bly-ioner op til næsten lysets hastighed, for derefter at kollidere dem med hinanden. Målet med dette er at forstå, hvordan de mindste ting i universet er bygget op, og hvordan de interagerer. Alle tidligere eksperimentelle data er kombineret til en enkelt teori, kendt som StandardModellen This thesis consider the improvement of the simulation tools used to describe high energy particle collisions. These simulation programs are normally referred to as event generators. The emphasis is on two specific parts of the event generation: the introduction of radiation of weak bosons associated with the collision and a new model for colour reconnection. Each collision contains significant
BACKGROUND: Liver resection is a possibly curative treatment for colorectal cancer (CRC) liver metastases. Preoperative chemotherapy may make initially irresectable tumors resectable. The aim of this study was to compare perioperative course and short-term mortality after liver resection for CRC metastases between patients who were and were not treated with preoperative chemotherapy. METHODS: Pati
The dynamical theory of X-ray spectra due to Nozieres and De Dominicis (ND, 1969) is evaluated here numerically for numerous model systems including cases where the core-hole potential possesses a bound state. It is shown that the resulting emission spectra obey the final-state rule rather accurately. An approximate but analytical derivation of this rule is given which provides insight into the me
Background. The aim of this study was to investigate the occurrence and appearance of the anastomosis between the two umbilical arteries in placentas from infants small for gestational age (SGA). Methods. The arterial systems of 64 placentas from singleton pregnancies resulting in SGA infants were visualized by angiography. The method allowed study of the anastomosis between the umbilical arterie
It is generally considered mammals and birds have five Tec family kinases (TFKs): Btk, Bmx (also known as Etk), Itk, Tec, and Txk (also known as Rlk). Here, we discuss the domains and their functions and regulation in TFKs. Over the last few years, a large number of genomes from various phyla have been sequenced making it possible to study evolutionary relationships at the molecular and sequence l
Handheld mobile phones were introduced in Denmark and Sweden during the late 1980s. This makes the Danish and Swedish populations suitable for a study aimed at testing the hypothesis that long-term mobile phone use increases the risk of parotid gland tumors. In this population-based case-control study, the authors identified all cases aged 20-69 years diagnosed with parotid gland tumor during 2000
The aim of this study was to develop, adjust and test two different methods for the estimation of drainage area and potential wetness in ridged fields. The methods were applied to a gridded digital elevation model (DEM) of a potato field in central Sweden. Elevation data were registered by a global positioning system (GPS) receiver. A high-precision real time kinematic (RTK) system was used to rec
District heating systems using cogeneration, as well as local fuel-based and electric heating systems for detached houses, are analysed. The analysis includes the whole energy system, from the natural resource to the end user, with respect to primary energy use, emission and cost. The end-use technologies studied are heat pumps, resistance heaters and boilers. It was assumed that the base-load ele
The immunocompetence handicap hypothesis proposes that testosterone (T)-dependent sexual signals are honest indicators of male health or genetic quality because only high-quality males are able to withstand the obligate effects of T-induced immunosuppression. In birds, the basic assumption that T suppresses immune function is equivocal, and the physiological mechanisms underlying T-induced immunos
BACKGROUND: The orexins (hypocretins) are recently discovered hypothalamic peptides that are involved in the regulation of sleep, appetite and state of arousal. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) orexin and specific psychiatric symptoms in suicidal patients. METHODS: A total of 101 patients were enrolled in the study shortly after a suicide att
Purpose: To document the management strategies and outcome of patients diagnosed with sac hygroma following open or endovascular abdominal aortic aneurysm (AAA) repair. Methods: Seven men (median 68 years, range 43-79) with previous open (n=3) or endovascular (n=4) AAA repairs and increasing aneurysm diameters documented on spiral computed tomography (CT) were diagnosed with sac hygroma based on t
Ovarian carcinoma is the fourth most common cause of cancer death in women. The cause and pathogenesis of this disease has remained obscure. Galactose, the hydrolyzing product of the milk sugar lactose, has been hypothesized to be toxic to ovarian epithelial cells and consumption of dairy products and lactase persistence has been suggested to be a risk factor for ovarian carcinoma. In adults, down
Studies have indicated that females are more vulnerable to the deleterious effect of tobacco smoking than males. The current study aimed to investigate the associations between tobacco smoking and reported respiratory symptoms, self-rated health, and lung function by sex. In 1995-1997 65,225 subjects aged greater than or equal to 20 yrs (71% of invited) attended for screening within the Nord-Trond
Exhaled breath condensate (EBC) analysis is a promising tool for diagnosis and management of pulmonary diseases. Its clinical usefulness is still limited however due to unresolved issues around e. g. reproducibility, anatomical site of origin of EBC solutes and mechanisms of EBC formation. To gain some knowledge on these issues, three different airway deposition patterns of an aqueous aerosol cont
Stereoselectivity has been known to play a role in drug action for 100 years or more. Nevertheless, chiral drugs have been developed and used as racemates, neglecting the fact that they comprise mixtures of two or more compounds which may have quite different pharmacological properties. A very limited access to pure enantiomers in the past has been responsible for this unsatisfactory state of affa
