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SpectraCure AB is a start-up company aiming at treating internal solid tumours such as prostate tumours with an innovative technology called ‘Interstitial Photodynamic Therapy’. This treatment requires the use of fibres to deliver the amount of light required to activate a drug injected to the patient which leads to the destruction of the tumours. This treatment is patient-based which means that t
OBJECTIVES: To evaluate the proportion of cardiovascular disease (CVD) incidence that is explained by genetic variation at chromosome 9p21 and to test whether such variation adds incremental information with regard to CVD prediction, beyond traditional risk factors. DESIGN, SETTING AND PARTICIPANTS: rs4977574 on chromosome 9p21 was genotyped in 24 777 subjects from the Malmö Diet and Cancer study
Objective To examine use of magnetic resonance imaging (MRI) of knees with no radiographic evidence of osteoarthritis to determine the prevalence of structural lesions associated with osteoarthritis and their relation to age, sex, and obesity. Design Population based observational study. Setting Community cohort in Framingham, MA, United States (Framingham osteoarthritis study). Participants 710 p
Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by
This thesis focuses on both street art and outdoor advertisements in Istanbul. Specifically, we chose Istiklal and Bağdat Avenues as our fieldwork areas to conduct our research. With its cosmopolitan structure Istiklal Avenue and high-standard lifestyle Bağdat Avenue together represent Istanbul to understand the multifaceted nature of social, cultural and political identities of the society. In re
Of all live births with congenital anomalies, approximately one-third exhibit deformities ofthe head and face. Most craniofacial disorders are associated with defects in a migratory stem and progenitor cell population, which is designated the neural crest (NC). Musculocontractural Ehlers-Danlos syndrome (MCEDS) is a heritable connective tissue disorder with distinct craniofacial features; this syn
Objective: The rate of failed interlock blood alcohol content (BAC) tests is a strong predictor of recidivism post-interlock and a partial proxy for alcohol use. Alcohol biomarkers measured at the start of an interlock program are known to correlate well with rates of failed BAC tests over months of interlock use. This study evaluates 2 methods of measuring low blood levels of the biomarker phosph
The purpose of this study was to examine whether the success of theconcept of empowerment in the field of social science can be explained by referring to it as the new paradigm replacing the former paternalistic era. Therefore, I investigate if the character of its history, domicile and practice has the same distinguishing features as the scientific progress. The analysis is based on Thomas Kuhn&#
Popular Abstract in Swedish Den första beskrivningen av diabetes mellitus gjordes redan 1500 före Kristus när en faraos läkare noterade att myror samlade sig omkring urin från vissa människor men inte andras. På 1700-talet beskrevs för första gången närvaron av större mängder socker i såväl blod som urin hos diabetiska patienter. På 1920-talet upptäcktes insulin i bukspottkörteln (pancreas) och saThe influence of trauma (acute pancreatitis) or total parenteral nutrition (TPN) on pancreatic islet hormone secretion in relation to islet expression of inducible nitric oxide synthase (iNOS) was investigated. Acute pancreatitis resulted in an impaired glucose-stimulated insulin secretion (GSIS) which was found to be parallelled by a marked expression of iNOS and an exaggerated NO production in t
The mechanical properties of major arteries may reflect early manifestations of vascular disease and are also of interest because they are important for cardiac work. Using echo-tracking sonography and blood pressure measurements, arterial stiffness and diameters were investigated in healthy individuals as well as in patients with insulin dependent diabetes mellitus (IDDM) or alpha1-ant
With the theme of the research conference of the NNHSH network we want researchers, both at doctoral and post-doctoral level, to reflect on how health practices and health policies in the Nordic Welfare States are being transformed and have been transformed in the past. The Nordic countries are all, more or less, in the midst of a transformation from a social democratic health care system, based o
Popular Abstract in Swedish Polymerer och tensider är två mycket vanliga molekylslag som vi ofta stöter på i vårt vardagliga liv. Polymerer är extremt långa kedjor sammansatta av tusentals repeterande enheter. De förekommer både som hårda material (t ex plast) och i lösning (t ex målarfärg). Det finns syntetiska polymerer, såsom nylon och polyeten, och det finns biologiska polymerer, t ex cellulosA new approach to the study of aqueous mixtures of oppositely charged polymers and surfactants has been introduced. Pure polyion-surfactant ion complex salts have been synthesized and used as the point of departure. The elimination of the simple ions reduces the number of components in the mixtures, thus greatly simplifying the system. By mixing the complex salt with either the polyelectrolyte or
Popular Abstract in Swedish Peptidaser, proteolytiska enzymer eller proteinhydrolaser är olika benämningar på samma sorts enzymer. Deras funktion är att bryta ner proteiner i alla celler, vävnader eller vätskor i antingen vår egen kropp eller i någon annan levande organism. Varför behövs dessa enzymer? Deras funktion påminner om den av en återvinningscentral, där peptidaserna avvecklar felfungeraProteolytic enzymes are enzymes that hydrolyze peptide bonds in peptides and proteins. This ability to carry out protein degradation is essential for many cellular and extracellular processes that occur in all living organisms. Cysteine peptidases constitute a class of proteolytic enzymes. Among these, papain-like (C1) peptidases are the mostly studied ones. Inhibitors regulate proteolytic activit
In this thesis I have studied factors that regulate submerged macrophyte abundance, morphology and distribution in shallow eutrophic lakes, and how submerged macrophytes may affect the ecosystem. Light attenuation through the water column (turbidity and water depth) is probably not the most important factor regulating the distribution of submerged vegetation in macrophyte dominated shallow eutroph
Peripheral tolerance is regulated by different types of regulatory T cells, including CD1-restricted T cells and CD4+CD25+ regulatory T (Treg) cells. This thesis has focused on the interactions between T cells and antigen presenting cells (APCs) and the immunregulatory function of TGF-b as two important factors regulating differentiation and activation of T cells in the periphery. In the first par
Popular Abstract in Swedish Proteiner är nödvändiga beståndsdelar i en levande cell. Dels bygger de upp viktiga strukturer och dels katalyserar de kemiska reaktioner. Proteiner kodas av gener. Varje protein motsvaras av en gen. Vägen från gen till protein är densamma i alla organismer på jorden. Först transkriberas en gen till en molekyl kallad mRNA (budbärar-RNA, eng. messenger RNA). Detta mRNA aDegradation of mRNA is a controlled process which is as important for gene regulation as the synthesis of mRNA. This thesis focuses on mechanisms of mRNA stability and degradation in Bacillus subtilis, the model of Gram-positive bacteria. The aprE mRNA, encoding an exported protease named subtilisin, is extremely stable with a half-life of more than 25 minutes. Average mRNA half-lives in B. subtil
Popular Abstract in Swedish En amfifil molekyl innebär en molekyl som består av två delar, en som är hydrofil (“vattenälskande”) och en som är hydrofob (“vattenhatande”). Ofta består den amfifila molekylen av en ”vattenälskande” huvudgrupp och en ”vattenhatande” svans och kallas för surfaktant. Detta beteende ger amfifila molekyler speciella egenskaper. En av de viktigaste egenskaperna är att de kIn this thesis temperature induced vesicle formation in both a block copolymer system and nonionic surfactant system have been investigated. The block copolymer is a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), PEO-PPO-PEO, with the average molecular composition of EO5PO68EO5 and the commercial trade name Pluronic L121 (papers I, II). In the L121 system the for
Bibliometric impact analyses show that Swedish research has less international visibility than Danish research. When taking a global view on all subject fields and selecting publications cited higher than the 90th percentile, i.e., the Top 10 %—publications, the Swedish Research Council shows that although Sweden ranks 15 % above world average, Denmark, the Netherlands and Switzerland rank 35–40 %
