Search results

Over the past couple of decades, considerable advances in automation and high-throughput omics technologies have contributed to the generation of unprecedented amounts of molecular data, challenging the traditional “one size fits all” approach in favour of personalised medicine, where the individual needs of patients are addressed.However, the speed at which such molecular data is being acquired d

Technical developments have paved the way for the development of ultrasensitive analytical methods that allow for precise quantification of brain-specific proteins in blood samples. Plasma levels of amyloid β, specifically the Aβ42/40 ratio, are reduced in Alzheimer's disease (AD) and show concordance with brain amyloidosis assessed by PET, but the overlap with normal elderly may be too large for

Background: The PI*S variant is one of the most prevalent mutations within alpha-1 antitrypsin deficiency (AATD). The risk of developing AATD-related lung disease in individuals with the PI*SS genotype is poorly defined despite its substantial prevalence. Our study aimed to characterize this genotype and its risk for lung disease and compare it with the PI*ZZ and PI*SZ genotypes using data from th

While many religious institutions promote hetero- and cis-normative notions of sex, gender, and sexuality, not all LGBTQIA+ people leave religion and not all people who practice religion are straight and cis-gendered. In my research, I explore the lived experiences of queer Jews, Christians, and Muslims in Sweden through on- and offline ethnographic fieldwork aiming to gain insight into how religi

Aims Short-term ambulatory electrocardiogram (ECG) monitoring is often used to assess premature atrial complex (PAC) and premature ventricular complex (PVC) frequency, but the diagnostic reliability is unknown. The objective of this study was to study the day-to-day variability of PAC and PVC frequency. Methods We used 14-day full-disclosure mobile cardiac telemetry recordings without atrial fibri

Background: Myocardial perfusion SPECT (MPS) and exercise electrocardiography (Ex-ECG) results are of prognostic importance for short-term follow up duration. However, the value of MPS or Ex-ECG findings for long-term risk assessment is less evident as underlying risk factors for ischemic heart disease (IHD) gain in importance. Objectives: To assess the short- and long-term prognostic value of MPS

Emotion dysregulation and psychological inflexibility are widely regarded as key contributors to a range of mental health issues and are integral to several treatment models in the mental health field. However, no study has examined whether the two constructs reflect distinct aspects of psychological functioning or whether they can be clearly differentiated from mental health symptoms and associat

Conventionally, a technical system is defined in the design phase and considers all important requirements and aspects. The expected operations and the circumstances of operations are to be known in advance. If these are known, then the designed system can even be validated before it is produced or launched on the market. Validation is typically based on predictive analyses or simulations. However

Background: Spironucleus salmonicida is an anaerobic parasite that can cause systemic infections in Atlantic salmon. Unlike other diplomonad parasites, such as the human pathogen Giardia intestinalis, Spironucleus species can infiltrate the blood stream of their hosts eventually colonizing organs, skin and gills. How this presumed anaerobe can persist and invade oxygenated tissues, despite having

Background: The integration of first- and second-generation bioethanol processes has the potential to accelerate the establishment of second-generation bioethanol on the market. Cofermenting pretreated wheat straw with a glucose-rich process stream, such as wheat grain hydrolysate, in a simultaneous saccharification and fermentation process could address the technical issues faced during the biolo

The sharing of indoor space can improve space and energy efficiency. The drivers and barriers to space-sharing initiatives are investigated from the perspectives of building users and building sector practitioners, based on interviews and a workshop. The role of energy performance metrics in promoting space efficiency is further analysed through a literature review. From the users’ perspective, sp

The nitrogen cycle and its effect on carbon uptake in the terrestrial biosphere is a recent progression in earth system models. As with any new component of a model, it is important to understand the behaviour, strengths, and limitations of the various process representations. Here we assess and compare five land surface models with nitrogen cycles that are used as the terrestrial components of so

Background: Response to modern treatment strategies, which combine cytotoxic compounds with immune stimulatory agents and targeted treatment is highly variable among MCL patients. Thus, providing prognostic and predictive markers for risk adapted therapy is warranted and molecular information that can help in patient stratification is a necessity. In relapsed MCL, biopsies are rarely available and