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Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M protein. Here, we engineer the IgG2-4 subclasses of Ab25. Despite having reduced binding, the IgG3 version promotes stronger phagocytosis of bacteria. Using atomic
An algorithm specific digital signal processor is a powerful alternative to a general purpose signal processor for demanding specifications such as high throughput, low power, small size, etc. These properties are achieved as the processor architecture is tailored to the algorithm as opposed to the general purpose architecture which must suit a wide range of algorithms. The increased performance i
Fractures of the distal end of the radius are common and occur in many different forms. The long-term results after conservative treatment of fracture of the distal end of the radius in younger adults with special reference to degenerative changes and function are investigated in 76 patients (Paper I). After 30 years, 81% of the patients made no difference between the fractured and the non- fractu
Popular Abstract in Swedish Europaparlamentet vill minska primärenergianvändningen samt minska beroendet av energiimport till unionen (EU Direktiv 2012/27/EU). Ett hjälpmedel för att uppnå detta mål kan vara användandet av individuell mätning och debitering (IMD) av värme och varmvatten i flerbostadshus. IMD innebär att boende i flerbostadshus endast ska betala för deras egen konsumtion, vilket skIndividual metering and charging (IMC) means that tenants in multi-apartment buildings should pay only for their own energy consumption, which gives an economic incentive for energy-conscious behaviour. In April, 2014, Swedish legislation about energy metering in buildings (SFS 2014:267) was passed by the Swedish Parliament as an implementation of the EU Energy Efficiency Directive 2012/27/EU. The
This thesis deals with specialization and how it is linked to sympatric speciation. The trait driving specialization is a cue recognition trait modelled with artificial neural networks that exploiters use to discriminate beneficial resources from detrimental resources based on the signals of the resources. Paper I investigates how haploid exploiters and the resources coevolve when the signals of t
Popular Abstract in Swedish Osteoporos (benskörhet) är en sjukdom som drabbar de äldre och leder till att skelettet urkalkas och därmed förlorar delar av sin styrka. Detta bidrager till olika typer av frakturer (brott av benet) där de vanligaste är handleds-, axel-, kot- och höftfrakturer. Andelen frakturer ökar i befolkningen, vilket både medför ökade kostnader för samhället och invaliditet för dThe aim of this thesis was to evaluate bone mass and bone size in girls and boys from age 12 to 16, with special attention to physical activity. We also wanted to retrospectively evaluate the effect of exercise for the years preceding age 12. The findings were as follows. Sixteen year old adolescents in a rural area had higher areal bone mineral density in the total body and the spine compared wit
Objective: To evaluate long-term oncological outcome and surgical quality of robotic radical hysterectomy for cervical cancer. Methods: Consecutive women with stage IA2 to IIA operated between March 2006 and May 2012 with a robotic radical hysterectomy and pelvic lymphadenectomy were prospectively followed up until five years after surgery or until death. Details regarding clinical results, recurr
Popular AbstractI takt med att svenska företag har ökat sina utlandssatsningar med bland annat direktinvesteringar på utländska marknader har också efterfrågan av internationell rörlighet bland den svenska kvalificerade arbetskraften ökat. En del av detta behov rör tidsbegränsade utlandsposteringar av svensk arbetskraft på så kallade ’expats-kontrakt’. Ofta utgår samhällsdebatten från en uppfattniAs Swedish companies have increased their commitments abroad, the demand for internationally mobile skilled Swedish labour has increased. Some of this demand concerns temporary positions on so called ’expats-contracts’. Often the discussion on this issue originates from a discourse that claims this type of labour force to be unanimously positive towards moving abroad to work. International tempora
Climate warming is driving changes in species distributions and community composition. Many species have a so-called climatic debt, that is, shifts in range lag behind shifts in temperature isoclines. Inside protected areas (PAs), community changes in response to climate warming can be facilitated by greater colonization rates by warm-dwelling species, but also mitigated by lowering extirpation ra
ScopeAccurate numerical modeling of fluid transport is essential in reservoir management. Higher-order methods help to improve accuracy by reducing the numerical diffusion, which is common for all first order methods. In this paper, we present an implementation of a MUSCL-type second-order finite volume method and demonstrate its capabilities on 2D and 3D unstructured grids. This includes corner p
Background Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) require lifelong treatment. The aim of the present study was to investigate adherence to disease-specific treatment in patients with PAH or CTEPH.Methods The study comprised an adult population diagnosed with PAH (n=384) or CTEPH (n=187) alive in 2016–2017. The study utilised three registries
BACKGROUND: Fish is a primary source of protein and n-3 PUFA but also contains methylmercury (MeHg), a naturally occurring neurotoxicant to which, at sufficient exposure levels, the developing fetal brain is particularly sensitive. OBJECTIVES: To examine the association between prenatal MeHg and maternal status of n-3 and n-6 PUFA with neurodevelopment, and to determine whether PUFA might modify p
The sharing economy has emerged as a potential way to reduce the environmental impact and costs of using products, whilst increasing their accessibility. However, there is a paucity of literature on its sustainability implications. To help fill this void we provide a first indicative assessment of the potential sustainability implications for the sharing of three product groups in Sweden, namely c
We present diagnostic criteria for motion sickness, visually induced motion sickness (VIMS), motion sickness disorder (MSD), and VIMS disorder (VIMSD) to be included in the International Classification of Vestibular Disorders. Motion sickness and VIMS are normal physiological responses that can be elicited in almost all people, but susceptibility and severity can be high enough for the response to
Context. High-precision stellar analyses require hydrodynamic 3D modeling. Such models predict changes across stellar disks of spectral line shapes, asymmetries, and wavelength shifts. For testing models in stars other than the Sun, spatially resolved observations are feasible from differential spectroscopy during exoplanet transits, retrieving spectra of those stellar surface segments that succes
Spectral induced polarization (SIP) is an increasingly interesting technique for field investigations since it can provide valuable information on the properties of the subsurface deposits or groundwater units. Field measurements can be carried out in the frequency domain (FD) or in the time domain (TD) but should lead to the same spectral subsurface description. IP measurements are superimposed b
