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Background: Prescription of antidepressant drugs (ADs) has increased in recent decades, with rising costs for patients as well as for the health care system. There is sparse evidence of which factors explain the high economic costs and financial burden for the general population. Aims of the Study: The aim was to assess individual-level determinants of out-of-pocket and total health care costs of
We investigated the skin sensitization hazard of glyphosate, the surfactant polyethylated tallow amine (POEA) and two commercial glyphosate-containing formulations using different omics-technologies based on a human dendritic cell (DC)-like cell line. First, the GARD™skin assay, investigating changes in the expression of 200 transcripts upon cell exposure to xenobiotics, was used for skin sensitiz
Objective: To evaluate the additive value of the prostate cancer gene 3 (PCA3) urine test to serum prostate-specific antigen (PSA) in prostate cancer (PC) screening among breast cancer, early-onset gene (BRCA) mutation carriers. This study was performed among the Dutch participants of IMPACT, a large international study on the effectiveness of PSA screening among BRCA mutation carriers. Materials
This thesis contributes to econometric methodology in terms of estimation and inference in static panel data models with unobserved multidimensional heterogeneity. When not properly accounted for, unobserved heterogeneity may introduce bias into the parameter estimates associated with covariates of interest, such as treatment indicators or determinants of macroeconomic indicators. A common way of
In this paper we present an outline of a research project that will be carried out in 2019 – 2021. Below we give a short summary of the project. SummaryThe flood of #metoo witness narratives has demonstrated the pervasiveness of sexual abuse. Yet, #metoo has also made visible different understandings of justice. The campaign against sexual harassment and violence has brought to the fore tensions b
Reaction of [Fe3(CO)9(µ3-Te)2] (1) with the corresponding phosphine has been used to prepare the phosphine-substituted tellurium-capped triiron clusters [Fe3(CO)9(µ3-Te)2(PPh3)] (2), [Fe3(CO)8(µ3-Te)2(PPh3)] (3) and [Fe3(CO)7(µ3-Te)2(µ-R2PXPR2)] (X = CH2, R = Ph (4), Cy (5); X = NPri, R = Ph (6)). The directly related cluster [Fe3(CO)7(µ3-CO)(µ3-Te)(µ-dppm)] (7) was isolated from the reaction of [
In this chapter, the pathophysiology and neurochemical pathology of epileptic brain damage is discussed on the basis of an integrative approach in which a comparison is made to cell necrosis resulting from ischemia and hypoglycemia. Two main questions are asked. First, is the brain damage resulting from these three disorders of cerebral energy metabolism similar in distribution and structural char
During World War II, Nils Hylander worked on his monumental theses about the wood lawn neophytes [German: Grassameneinkömmlinge] of Swedish parks. Most probably, the original aim was to date and locate the sources of the imported seed that had obviously been widely used in the 1800’s for establishing lawns in parks of the English style, but due to restrictions to work and travel during the war, H
While surgery is a cornerstone in treatment of peripheral nerve injuries, it is not a comprehensive approach, and outcome is unsatisfactory, especially sensory function. The present aim was to translate recent findings about stem- and progenitor cells to improve regenerative outcome, where the cells have to be autologous, available within the same surgical procedure, and minimally manipulated. Gra
The nonionic low-osmolar contrast medium iohexol was used as marker of glomerular filtration rate (GFR) in 53 patients with stable renal function (group I: n = 32, group II: n = 21). All the patients had clearance values < or = 30 ml.min-1.1.73 m-2 body surface; 40 patients < 20 ml.min-1.1.73 m-2 body surface. Simultaneous determinations of renal clearance and plasma clearance, both as slope clear
Aim: Head injury is the most common trauma occurring in syncope. We aimed to assess whether syncope as cause of head-trauma affects short-and long-term prognosis. Methods: From a database retrospective analysis of 97,014 individuals attending Emergency Department (ED), we selected data of patients with traumatic head injury including age, gender, injury mechanism, brain imaging, multiple traumas,
Groundwater (GW) is being uncontrollably exploited in various parts of the world resulting from huge needs for water supply as an outcome of population growth and industrialization. Bearing in mind the importance of GW potential assessment in reaching sustainability, this study seeks to use remote sensing (RS)-derived driving factors as an input of the advanced machine learning algorithms (MLAs),
The combined contribution to highway safety of pavement surface and geometric design indicators is not well investigated due to the complexity of data collection and high time variability of pavement surface conditions. Introduction of high efficiency equipment for comprehensive road surveys is mitigating this issue, expanding possibilities of data integration. In this framework, the present study
This is a review of the recent publication “Pharmaceutical Innovation, Competition and Patent Law – A Trilateral Perspective”, edited by Max Planck Director Josef Drexl and Finnish scholar Nari Lee (Edward Elgar 2013, 322 p., ISBN 978 0 85793 245 7). In summary, I conclude that the editors, who also contributed with excellent papers, have succeeded very well in the difficult task of structuring, s
Objective: In the province of Brescia, Italy, historical neurotoxic metal exposure has occurred for several decades. This study aimed to explore the role of metal exposure and genetics on Parkinson's Disease (PD) and Parkinsonism. Methods: Cases were enrolled from four local clinics for movement disorders. Randomly selected controls non-affected by neurological or psychiatric conditions were enrol
‘Creativity’ has become a buzzword throughout educational debates and strategy papers worldwide. By linking creativity to innovative capacity, it is commonly associated with the challenges and opportunities as generated by the knowledge economy. While the importance of creative approaches to learning is generally accepted, it has proven much more difficult to define and potentially assess skills a
Arguably among the most globally impactful climate changes in Earth's past million years are the glacial terminations that punctuated the Pleistocene epoch. With the acquisition and analysis of marine and continental records, including ice cores, it is now clear that the Earth's climate was responding profoundly to changes in greenhouse gas
