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Popular AbstractI början på 1990-talet drabbades Sverige av en mycket djup ekonomisk kris. Den svenska nittiotalskrisen uppfattades inte som en tillfällig konjunkturnedgång utan som symptom på grundläggande systemfel i Sveriges ekonomi. Många bedömare menade att den s.k. svenska modellen med stor välfärdsstat och höga skatter hade försämrat marknadsekonomins effektivitet och gjort att Sverige undeIn the early 1990s, Sweden was hit by a profound economic crisis. The Swedish crisis of the nineties was not perceived as a temporary recession, but rather as a fundamental and systemic fault in Swedish economy. Many commentators held that the Swedish model with a large welfare state and high taxes had impaired Sweden's economic performance. The aim of this thesis is to empirically assess the hypo

Popular Abstract in Swedish Koncentrationer av proteiner i plasma och urin används i ökande utsträckning i diagnostik av njursjukdomar och i studier av den glomerulära barriärens funktion. De viktigaste frågor som behandlats i denna avhandling var: förvaring av urinprover inför efterföljande proteinanalyser, tillämpningar av proteinkoncentrationer i urin och plasma vid hälsa och vid glomerulära (nPlasma and urine concentrations of endogenous proteins are frequently used in the diagnosis of kidney diseases and in studies of glomerular filter function. The main issues addressed in these studies were: storage of urine samples for subsequent protein analysis, use of protein concentrations in urine and in plasma in health and as markers of glomerular diseases, and the application of renal plasm

Popular Abstract in Swedish Vi är under ständig attack från mikroorganismer som vill leva på oss och i oss. Vissa av dessa är vanligtvis nyttiga medan andra är sjukdomsframkallande. Kroppens försvar mot invaderande organismer består av många delar. Ytterst sitter huden som en mekanisk barriär, vi har slem och epitelceller i luftvägar och magtarmkanal samt skyddande ämnen i exempelvis tårvätska. I Transplantation antigens encoded in the major histocompatibility complex (MHC) bind peptides and present them to T cells. We showed that mouse T cells expressing transgenic human CD8 can recognise human MHC class I. Expression on mature T cells is sufficient for activation in a mixed lymphocyte culture but expression both on thymocytes and mature T cells is necessary for peptide specific MHC restr

This paper presents an analysis of the point-spread functions (PSFs),which may be expected in the so-called improved seeing limited mode forthe Euro50 (Extremely large telescope with a 50 m aperture). This modecomprises adaptive control of the deformable secondary mirror of theaplanatic Gregorian telescope configuration using guide stars in a widefield. I may result in efficient compensation of tu

A sustainable development of the built environment asks for changes in urban residents’ mobility patterns. The extensive use of the car contributes to sedentary lifestyle and negative environmental impact in many respects. Children living in urban areas are faced with limits of their independent use of the environment both in terms of travel and outdoor play. Many parents hold favourable attitudes

This thesis makes a contribution to matching theory. It consists of five self-contained papers. It is a study predominately on the existence of stable outcomes. These are desirable both from a practical and a theoretical standpoint. Matching theory has grown in importance in recent years following its successful applications to, for instance, kidney exchange, the National Resident Matching Program

This thesis is about the flight of vertebrates and the studies of different modes of flight. Flight has always fascinated mankind and this fascination gave inspiration for our attempts at flying. Yet there are many different modes of flight among vertebrates and this thesis focuses mainly on the flapping flight of bats and intermittent flight of birds, as well as compares some of the factors conce

Purpose - This paper aims to explore the electronic design of the Touch Hand: a low-cost electrically powered prosthetic hand. The hand is equipped with an array of sensors allowing for position control and haptic sensation. Pressure sensors are used on the fingertips to detect grip force. A temperature sensor placed in the fingertip is used to measure the contact temperature of objects. Investiga

In order to properly design an absorption tower for CO2 capture knowledge on the absorption rate of CO2 is required. Several methods can be used to determine the absorption rate, such as a wetted wall column (WWC), stirred absorption cell or a string of discs setup. The aim of this work was to determine the absorption flux of CO2 into different amine solutions using anew method. Two absorption sys

A reliable assessment of the optical properties of atmospheric black carbon is of crucial importance for an accurate estimation of radiative forcing. In this study we investigated the spatio-temporal variability of the mass absorption cross-section (MAC) of atmospheric black carbon, defined as light absorption coefficient (σap) divided by elemental carbon mass concentration (mEC). σap and mEC have

Popular Abstract in Swedish Intresset för evidens-baserad vård växer snabbt men trots att nya forskningsresultat produceras och publiceras löpande, tar det lång tid innan de får genomslag i den vård som erbjuds patienter och brukare. Det finns beräkningar som talar för att det tar mellan åtta och trettio år innan tillgängliga forskningsresultat har blivit implementerade och börjat användas rutinmäThe aim of this thesis was to investigate and synthesise the knowledge base concerning leadership and its influence on the implementation of evidence-based practice. A further aim was to investigate attitudes and beliefs among politicians, healthcare managers and mental healthcare professionals about the Swedish national guidelines for schizophrenia or schizophrenia-like conditions. Data was colle

Popular Abstract in Swedish Partiella differentialekvationerna} är kraftfulla verktyg som kan användas för att beskriva fysikaliska fenomen inom bland annat naturvetenskap, teknik, ekonomi och medicin. Listan med tillämpningar kan göras hur lång som helst: Partiella differentialekvationer kan beskriva hur en snöflinga bildas, hur strukturer deformeras när de utsätts för mekaniska krafter, hur blodSplitting methods are widely used as temporal discretizations of evolution equations. Such methods usually constitute competitive choices whenever a vector field can be split into a sum of two or more parts that each generates a flow easier to compute or approximate than the flow of the sum. In the research presented in this Licentiate thesis we consider dissipative evolution equations with vector

The rationale for thrombolysis, the most promising pharmacological approach in acute ischaemic stroke, is centred on the principal cause of most ischaemic strokes: the thrombus that occludes the cerebral artery, and renders part of the brain ischaemic. The occluding thrombus is bound together within fibrin. Fibrinolysis acts by activation of plasminogen to plasmin; plasmin splits fibrinogen and fi

Popular Abstract in Swedish Celler som har förmågan att ge upphov till nästan alla typer av mogna celler i en organism kallas för pluripotenta stamceller. Förutom deras förmåga att bilda olika specialiserade celltyper har pluripotenta stamceller även den unika förmågan att genomgå ett obegränsat antal celldelningar. Under utvecklingen av en organism genomgår pluripotenta stamceller en process somDuring direct cellular reprogramming, forced expression of key transcription factors (TFs) directly converts one terminally differentiated cell type into that of another fate, exemplified in this theses by the conversion of fibroblasts into functional induced neurons (iNs). Direct conversion of mouse fibroblasts to functional neurons was established in 2010, and the starting point of my doctoral

The general aim of the thesis was to contribute to a more evidenced based framework in the surgical treatment of diseases in the gastroesophageal junction (GEJ), by comparing outcome, measured by complication and survival rates, and evaluate different reconstructions regarding long-term symptoms and quality of life (QoL). The GEJ is a poorly defined anatomic area that represents the lower part of

BACKGROUND: Despite their pivotal roles in colorectal carcinogenesis, the interrelationship and prognostic significance of beta-catenin alterations and microsatellite instability (MSI) in colorectal cancer (CRC) needs to be further clarified. In this paper, we studied the associations between beta-catenin overexpression and MSI status with survival from CRC, and with expression of p21, p27, cyclin

Low bone mineral density (BMD) is a risk factor for fractures and much of the fracture preventive effort today is devoted to preventing low BMD. Physical activity (PA) has been described as one of the best strategies to optimize skeletal development in the growing child. However, most exercise intervention studies in children have involved the use of volunteers and specifically designed high impac

Recommendations stated in the TASC II guidelines for the treatment of peripheral arterial disease (PAD) regard a heterogeneous group of patients ranging from claudicants to critical limb ischaemia (CLI) patients. However, specific considerations apply to CLI patients. An important problem regarding the majority of currently available literature that reports on revascularisation strategies for PAD

Malignant brain tumor is a highly invasive and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. The aims of the present thesis have been to develop and explore a stem cell based vector system for delivery of therapeutic transgenes to experimental gliomas. First, we investig