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The comparative study of planetary systems is a unique source of new scientific insight: following the six “key science questions” of the “Planetary Exploration, Horizon 2061” long-term foresight exercise, it can reveal to us the diversity of their objects (Question 1) and of their architectures (Question 2), help us better understand their origins (Question 3) and how they work (Question 4), find

BACKGROUND: Breast cancer in young adults has been implicated with a worse outcome. Analyses of genomic traits associated with age have been heterogenous, likely because of an incomplete accounting for underlying molecular subtypes. We aimed to resolve whether triple-negative breast cancer (TNBC) in younger versus older patients represent similar or different molecular diseases in the context of g

Acute myeloid leukemia (AML) is a highly heterogeneous blood disease which is characterized by different mutations and chromosomal rearrangements. Nearly 60% of genetic alterations have been found in AML patients involve in signaling pathways including signaling of tyrosine kinase receptor FLT3. FLT3 mutations emerged as one of the most common mutations in AML which represent around 35% of all AML

Fysisk aktivitet är en hälsofrämjande livsstilsfaktor som minskar risken för flera kroniska sjukdomar såsom hjärt-kärlsjukdomar, diabetes typ 2, depression och vissa typer av cancer. En av cancerformerna där risken minskas är bröstcancer som är den vanligaste cancern hos kvinnor, i Sverige insjuknar ungefär 7 500 kvinnor per år. Bröstcancer kan delas in i olika subgrupper som till viss del styr be

The research area of climate field reconstructions has developed strongly during the past 20 years, motivated by the need to understand the complex dynamics of the earth system in a changing climate. Climate field reconstructions aim to build a consistent gridded climate reconstruction of different variables, often from a range of climate proxies, using either statistical tools or a climate model

STOFFENMANAGER® and the Advanced REACH Tool (ART) are recommended tools by the European Chemical Agency for regulatory chemical safety assessment. The models are widely used and accepted within the scientific community. STOFFENMANAGER® alone has more than 37 000 users globally and more than 310 000 risk assessment have been carried out by 2020. Regardless of their widespread use, this is the first

In patients with suspected venous thromboembolism (VTE), it is recommended to estimate the pre-test probability of VTE, either by experience or by standardized scoring schemes (e.g. Wells or Geneva score), before performing a D-dimer test [1], [2]. Patients with a low probability or unlikely VTE should have D-dimer performed, and if negative, VTE can be excluded, without further investigations, wh

Periprostheteic joint infection (PJI) is a rare complication of arthroplasty with severe consequences for the affected patients. PJI most often necessitates additional surgery and prolonged courses of antibiotic treatment, leading to worse functional results and increased societal costs. Evaluating treatment of PJI as well as preventive efforts are essential to increase our understanding of PJI an

Organisms are continually challenged by multiple threats in the environment, and such threats are seldom constant in either time or space. Therefore, organisms must maintain physiological, behavioural, morphological and life- history adaptations across environments to prevent reductions in fitness. Freshwater ecosystems are particularly variable environments, and so organisms inhabiting lakes and

The capacitive biosensor technology can be utilized for the analytical detection of a variety of different compounds. By employing the electrical double-layer principle, it is possible to detect very low concentrations of the target analyte due the methods inherent high sensitivity. This affinity-based capacitive biosensor is a powerful tool also for the analytical detection of low molecular weigh

Nanotechnology and engineered nanomaterials (ENM) empower existing technologies. One of the great examples are III-V semiconductor nanowires (NW), which have a broad application range. The occupational safety and hazard organizations draw attention to ENM, as their physical and chemical characteristics differ from the ones of bulk materials. Additionally, the NW high aspect ratio geometry is of gr

With a commitment to a relational ontology, scholars from within the feminist care tradition of animal ethics have been able to theorize how our moral significance - as well as our moral obligations to others - arise from the metaphysical and empathetic 'entanglements. Independent of species, gender and the like, we exist as embodied beings. Sharing a position that originates in nonwestern culture

Proteiner är fascinerande makromolekyler som är fundamentala för alla levandeorganismer. De utgör byggstenar i våra celler, ansvarar för transport och signalering både inom och mellan våra celler, utgör en del av vårt immunförsvar och katalyserar bildningen av andra molekyler. Proteiner består av flexibla kedjor uppbyggda av olika aminosyror. Varje aminosyra har olika egenskaper och den specifika Proteins are complex macromolecules that are fundamental to all living species. The stability of proteins are governed by non-covalent forces within the protein and between the protein and its surrounding environment. At high concentrations proteins are susceptible to self-association, which may lead to amyloid fibril formation – a process linked to many diseases, such as Alzheimer’s disease, Park

Different tau biomarkers become abnormal at different stages of Alzheimer's disease, with CSF phospho-tau typically becoming elevated at subthreshold levels of tau-PET binding. To capitalize on the temporal order of tau biomarker-abnormality and capture the earliest changes of tau accumulation, we implemented an observational study design to examine longitudinal changes in Tau-PET, cortical thickn

This study examines health-seeking, healing practices, gender and authority in a charismatic, locally founded church, the International Church for Healing and Glory (ICHG) in Mbeya, Tanzania. Based on ten months of ethnographic fieldwork carried out in 2013 and 2014, it addresses the situation of people who resort to faith-healing in a medically pluralistic context. The ICHG is a church led by a m

I ett hållbart samhälle är tillgänglighet en viktig förutsättning för alla, oavsett deras bakgrund. Det finns olika komponenter som ingår inom begreppet tillgänglighet. En av dessa komponenter handlar om transportmöjligheten, att man ska ha möjlighet att transportera sig till olika punkter med minsta möjliga reseuppoffring. Detta kan uppnås med hjälp av kollektivtrafiken, eftersom kollektivtrafik

Bulleremission från vägtrafik är på många ställen i Sverige ett påtagligt problem. Många fastigheter och rekreationsområden ligger så nära vägnätet att de utsattas hälsa och livskvalitet riskerar att försämras vid långvarig exponering. Att åtgärda bullerproblematiken direkt vid källan med en lågbullerbeläggning är idag en stor strävan på många platser. Detta ef-tersom de traditionella åtgärderna sNoise from road traffic is a significant problem in many places in Sweden. A lot of properties and recreational areas are so close to the road network that the health and quality of life of the exposed are at risk of deterioration. Addressing the noise problem directly at the source with a low noise road surface is a great endeavor in many places today. This is because the traditional measures suc