C–H activation through late transition metal cyclometallation. Addressing selectivity and reactivity problems.
Popular Abstract in English Synthetic chemicals are the basis of the modern civilisation. Nowadays, they have a bad reputation, but it is only due to them that we are able to live healthier, longer, receive improving medical treatments, use the comforts of modern technologies and not die of thirst and starvation, despite the immense population growth. The main task of organic synthesis is to transThe ligand-directed C—H activation relies on a coordinating donor atom being in proximity to the C—H bond activated. Cyclometallation of 2-(1-naphthyl)-pyridine – a substrate containing both γ- and δ-positions in proximity to the directing nitrogen atom – was studied. Cycloruthenation and cyclopalladation result in γ-substitution and formation of the corresponding 5-membered metallacycles, which i