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Prostaglandin E2 (PGE2) is synthesized by cyclooxygenase 2 (COX-2) in the arachidonic acid pathway. PGE2 promotes cancer initiation and progression while facilitating chronic inflammation and immunosuppression, partly through regulation of programmed death ligand 1 (PD-L1) in tumor cells and tumor-associated macrophages. PGE2 also modulates Hippo signaling, enhancing nuclear Yes-associated protein

The paper reviews current trends and future directions for diagnostics and therapy with ionizing radiation. Recent advances in medical physics applied to radiation therapy, diagnostic radiology, nuclear medicine, MRI, and radiation safety are summarized. Today, much of the development is concentrated on providing conditions for individualized diagnostics and therapy for the patient, which requires

Aims: Testing insulin resistance could help improve physician assessment of patients’ risk of prediabetes or type 2 diabetes (T2D), even among normoglycemic individuals. Methods: The longitudinal study followed 16,333 normoglycemic participants in a nation-wide employer-sponsored health assessment program starting in August 2020 with a median follow-up time of 2.9 years for incident prediabetes or

Some political parties employ clientelist practices to gain voter support. Yet as more citizens now vote from abroad, little is known about parties engaging in clientelism domestically versus transnationally. We propose parties adopt either a replication or differentiation approach, meaning they apply similar or different campaigning strategies abroad. Using a large-N sample of voter turnout in So

The production of neuroepithelial stem (NES) cells, a promising therapeutic candidate for neurological conditions such as stroke and spinal cord injuries, faces significant manufacturing challenges, particularly in quality control (QC). Specifically, current QC methods rely on labor-intensive manual assessments that are costly, time-consuming, and subject to operator bias, limiting scalability and

Spectrum arguments are purported to show that the betterness relation is not a transitive relation. This is a drastic conclusion since much normative theorizing and everyday reasoning assume that betterness is transitive. In order to avoid this conclusion, many reject a plausible view on trade-offs between quality and quantity. The rejection can take the form of a radical or a conservative rejecti

Ett radioaktivt nedfall efter ett kärnkraftshaveri kan resultera i kontamination av stora landområden. I syfte att skydda människors hälsa mot joniserande strålning kan storskalig sanering vara nödvändig. Sverige saknar nationell erfarenhet av denna typ av storskalig sanering. Det finns därmed stora osäkerheter i verkan av en sådan sanering som bl.a. är beroende av de enskilda saneringsåtgärdernas

This article presents a search for a heavy charged Higgs boson produced in association with a top quark and a bottom quark, and decaying into a W boson and a 125 GeV Higgs boson h. The search is performed in final states with one charged lepton, missing transverse momentum, and jets using proton-proton collision data at s = 13 TeV recorded with the ATLAS detector during Run 2 of the LHC at CERN. T

Objectives Structural valve deterioration is an inherent limitation of bioprosthetic valves; however, the time it takes to develop varies depending on the valve model. The Sorin Soprano aortic bioprosthetic valve (Sorin Group/LivaNova, Milan, Italy) lacks reported long-term results. This study aims to establish the long-term durability of this bioprosthetic valve in a nationwide cohort. Methods Al

Objectives Critically ill COVID-19 patients admitted to the intensive care unit (ICU) are at an increased risk of acquiring bacterial bloodstream infections (BSI). We aimed to describe patient characteristics, risk factors, and the microbiological spectrum in blood cultures and evaluate the impact of ICU-acquired BSI on outcomes in a Nordic setting. Methods A prospective multicenter cohort study w

Denna uppsats behandlar diskrimineringsrättens förbud mot bristande tillgänglighet i arbetslivet och analyserar hur långt arbetsgivarens skyldighet att vidta anpassningsåtgärder för arbetstagare med funktionsnedsättning sträcker sig. Med utgångspunkt i en rättsdogmatisk metod undersöks gällande rätt genom analys av svensk diskrimineringslagstiftning, EU-rätt, internationella åtaganden enligt FN:s This thesis examines the prohibition of lack of accessibility under discrimination law in working life and analyses the extent of employers’ obligations to implement reasonable accommodation measures for employees with disabilities. Using a legal dogmatic method, the study analyses current law through Swedish discrimination legislation, EU law, international obligations under the UN Convention on

The old duality that eventually came to produce the mind/body-problem indicates the problem of transcendental subjectivity. The enduring significance of this problem shows itself in a provocation of any paradigm that has become too objectivistic, too naturalistic – even too idealistic in a certain sense – and too forgetful of its own departure from a perspective always presumed. Analytic philosoph

Background In patients with stage III cutaneous melanoma, adjuvant treatments with PD-1 and BRAF+MEK inhibitors were approved based on improved recurrence-free survival. However, as the treatments have significant side effects and costs, the effect on overall survival remains a matter of great importance. Methods Clinical and histopathological parameters were obtained from the Swedish Melanoma Reg

With organic solar cells surpassing 20% efficiency, the focus is shifting toward understanding the more complex mechanisms in ternary blends. This work investigates the distinct working principles of ternary organic solar cells based on a polymer donor (D) and a nonfullerene acceptor (NFA), with a fullerene acceptor (FA) as the third component. A systematic comparison between ternary D:NFA:FA syst