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Spermine, a pivotal player in biomolecular condensation and diverse cellular processes, has emerged as a focus of investigation in aging, neurodegeneration, and other diseases. Despite its significance, the mechanistic details of spermine remain incompletely understood. Here, we describe the distinct modulation by spermine on Alzheimer’s Tau and Parkinson’s α-synuclein, elucidating their condensat

Background: Self-rated health (SRH) is an international measure and indicator of mortality and morbidity that can be used as a mortality predictor in adulthood. This study aimed to examine the status of SRH among adults in Qazvin Province and its relationship with physical activity levels and demographic factors in primary care centers. Methods: This is a cross-sectional study. We included data fr

The abundance and star formation histories of satellites of Milky Way (MW)-like galaxies are linked to their hosts' assembly histories. To explore this connection, we use the PARADIGM suite of zoom-in hydrodynamical simulations of MW-mass haloes, evolving the same initial conditions spanning various halo assembly histories with the VINTERGATAN and IllustrisTNG models. Our VINTERGATAN simulations o

Reconstructing ecological niche evolution can provide insight into the biogeography and diversification of evolving lineages. However, comparative phylogenetic methods may infer the history of ecological niche evolution inaccurately because (a) species' niches are often poorly characterized; and (b) phylogenetic comparative methods rely on niche summary statistics rather than full estimates of spe

Background and aim: The MY PD-CARE digital tool is intended to empower people with Parkinson’s disease (PD) and care partners to actively identify and track changes in key symptoms of advancing PD and to facilitate discussions with healthcare professionals (HCPs). MY PD-CARE was adapted from MANAGE-PD, a validated, web-based tool that helps HCPs identify patients with inadequate symptom control. T

This study gives an insight how new technology-based-firms (NTBFs) take part in investment readiness programmes (IRP) in practice and how this differs from the theoretical model by Mason and Harrison (2001). The first part of this study focuses on NTBFs, the role the play in the economy, the challenges they face and their need for financial resources. Furthermore, this paper explains the theoretic

Globaliseringen har lett till att ett nytt område inom varumärkesforskningen har vuxit fram, nation branding. Det råder delade meningar på forskningsfältet kring vad begreppet innebär, men den gemensamma nämnaren återfinns i att nation branding är en mer komplicerad variant av traditionell marknadsföring. Studiens syfte är att bidra med kunskap kring hur svenskhet konstrueras i nation branding, viGlobalization has led to the rise of a new field within brand research, nation branding. The opinions are separated on the research field, concerning the meaning of the term. The common denominator is though that nation branding is a more complicated version of traditional marketing. This study aims to contribute with knowledge about how Swedish culture is constructed in nation branding, through t

The following thesis research deals with the topic of the challenges technology start- ups face and overcome when hiring talents in comparison with HRM practices attributed to established firms by existing theory. As Masters in Entrepreneurship students we felt the current literature tends to focus on HR-related topics in established companies, while these subjects remain underdeveloped applying t

Uppsatsen behandlar den i Inger Christensens författarskap centrala frågan om antropocentrism. Det vill säga frågan om människans plats i och förhållande till världen. Specifikt undersöks diktboken "alfabet" från 1981, och de formella medel som där tas i bruk för att representera världen utan det mänskliga subjektet som centrum. Uppsatsen visar också på den antropocentriska frågan som

Denna uppsats grundar sig i en kvalitativ studie som behandlar en analys av utvalda teoretiska rekommendationer ställda mot det praktiska arbetet vid IT-utvecklingsprojekt, med fokus på kritiska faktorer. Huruvida lyckat ett IT-utvecklingsprojekt är baseras ofta på hur väl kundens krav tillgodosetts av leverantören. I vår studie valde vi att jämföra sex utvalda teoretiska modeller inom IT-utveckl

The thesis examines the relationship between expanding coverage of fiber optic broadband and employment in Swedish municipalities during 2007-2011 using a fixed effects panel and an instrumental variables model. Increased fiber coverage among households is estimated to have a negative effect on municipal employment whereas increased coverage among workplaces is weakly positively related to employm