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In biotechnological industries, downstream processing is a bottleneck in the complete production process. There is a wish to reduce the costs and therefore one tries to operate separation technology in continuous mode. Conventional SMB is a continuous countercurrent separation process, which is based on mathematical modeling and simulation studies for separation of binary mixtures of components.
AbstractAquaporins are membrane integral proteins that facilitate the transport of waterand/or other small neutral molecules across biological membranes in cells in allforms of life. Among the subfamilies of aquaporins in higher plants, the X IntrinsicProteins (XIPs) are the most recently discovered subfamily and the leastcharacterized. However, the aromatic/arginine (ar/R) selectivity filter and
Nitrous oxide (N2O) is a greenhouse gas formed during biological wastewater treatment under aerobic and anoxic conditions. Two reasons for high N2O emissions are low oxygen concentration during nitrification and low carbon/nitrogen-ratio during denitrification. In this full-scale study of N2O emissions from a sequencing batch reactor for treating digester supernatant, the oxygen concentration was
Metastasis is a complex process that remains a major challenge in the clinical management of cancer, because most cancer-related deaths are attributed to disseminated disease rather than the primary tumor. Despite the significant advances in the prediction of prognosis, and therapeutic management of primary breast cancers, coupled with the substantial improvement in our understanding of the molecu
Popular Abstract in English Popular science Microbial cells are small and difficult to handle in industrial processes, especially if they are to be reused subsequent batches. In order to make them easier to handle, these cells can be attached to a solid support, by so-called immobilization. This provides particles of sizes that are easy to filter and reuse. However, immobilization is associated wiAbstract Due to the finite nature of fossil resources and their environmental impact, such as greenhouse gases and climate change, the bio-based production of chemicals, materials and fuels is the subject of extensive research in industrial biotechnology. Biotransformation and fermentation are considered to be mild, “green” processes that make use of effective and reliable biocatalysts to provide
Protein misfolding is a frequently occurring event in living cells and without the quality control, the consequences are disasterous. In this thesis, we studied protein misfolding in vitro by employing a variety of fluorophores, to either detect the highly ordered aggregates of intrinsically disordered proteins/peptides or slight misfolding of a natively folded protein. Misfolding and concurrent
An experimental and computational study of the near-wall combustion in a Homogeneous Charge Compression Ignition (HCCI) engine has been conducted by applying laser based diagnostic techniques in combination with numerical modeling. Our major intent was to characterize the combustion in the velocity- and thermal boundary layers. The progress of the combustion was studied by using fuel tracer LIF, t
Inflation targeting is a common monetary policy regime. Inflation targets are often flexible in the sense that the central bank allows inflation to temporarily deviate from the target to avoid causing unnecessary volatility in the real economy. In this paper, we propose modeling the degree of flexibility using an autoregressive fractionally integrated moving average (ARFIMA) model. Assuming that t
Chloride anation of trans-Pt(CN)4ClOH2− has been studied with and without Pt(CN)42− present at 25.0°C by use of stopped-flow and conventional spectrophotometry and a 1.00 M perchlorate medium. The rate law in the absence of Pt(CN)42− is compatible with a chloride assistance via an intermediate of the type Cl-Cl-Pt(CN)4···OH22−, in which the reactivity of the aqua ligand is enhanced due to a partia
Room-temperature ionic liquids (RTILs) are compounds composed entirely of ions, which are liquid at temperatures below 100 degrees Celsius. Their high ionic strength and strong coupling make them useful for a number of applications, e.g. as electrolytes in supercapacitors. These properties also make them interesting subjects for theoretical research, as the canonical theories of the electrical dou
