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Summary A demographic survey was made of all children (n= 137) born with severe or moderate haemophilia in Sweden during the period 1970‐92. Bn addition, all prenatal diagnoses (n= 86) performing during the period were evaluated. The annual incidence of severe and moderate haemophilia, having remained constant for decades, increased from 0.78/10,000 males in the 1970s to 1.34 in the 1980s, levelli

Coagulation factor V (FV) deficiency is characterised by variable bleeding phenotypes and heterogeneous mutations. To add new insights into the FV genotype-phenotype relationship, we characterised the R1698W change in the A3 domain, at the poorly investigated interface with the A2 domain. The FV R1698W mutation was responsible for a markedly reduced expression level (10% of FV-WT) and specific act

The 2nd generation bioethanol will be produced from lignocellulose biomass including agricultural residues such as bagasse, straw, and stover, forest products residues and dedicated energy crops. The bioconversion of lignocellulose raw materials to ethanol requires microorganisms that are able (i) to ferment both hexose and pentose sugars present in lignocellulose and (ii) to tolerate and to remai

Seventeen ETV6/RUNX1-positive pediatric acute lymphoblastic leukemias were investigated by high-resolution array-based comparative genomic hybridization ( array CGH), gene expression profiling and fluorescence in situ hybridization. Comparing the array CGH and gene expression patterns revealed that genomic imbalances conferred a great impact on the expression of genes in the affected regions. The

A novel method for lactose determination in milk is proposed. It is based on oxidation of lactose by cellobiose dehydrogenase (CDH) from the basidiomycete Phanerochaete chrysosporium, immobilised in an enzyme reactor. The reactor was prepared by cross-linking CDH onto aminopropyl-silanised controlled pore glass (CPG) beads using glutaraldehyde. The combined biosensor worked in flow injection analy

Biorefining of crops for production of power, transport fuels, and a diverse array of chemicals has potential for providing significant added economic value to biomass. A shift in the industrial resource base from fossil resources to biomass also requires a shift in the technology base for producing, handling, and processing of raw materials. Biotechnology will play an important role in providing

The use of a cryogel in a combined application as a solid support for automated synthesis of a peptide ligand followed by affinity chromatography of a target protein is evaluated. The advantage, of synthesizing the ligand directly on the cryogel, is the circumvention of the standard process of synthesizing a peptide on a solid support, followed by cleavage, purification, analysis, and finally immo

Severe acute pancreatitis (AP) is characterized by leukocyte infiltration and tissue injury. Herein, we wanted to examine the potential effects of thrombin-derived host defense peptides (TDPs) in severe AP. Pancreatitis was provoked by infusion of taurocholate into the pancreatic duct or by intraperitoneal administration of L-arginine in C57BL/6 mice. Animals were treated with the TDPs GKY20 and G

Glycoside hydrolase family 19 chitinases are found in plants, bacteria and viruses, playing various roles. Plant chitinases are important for defence and development, whereas bacterial examples are useful for nutrition. The available structural studies show that family 19 enzymes are highly alpha-helical bi-lobed structures with a wide cleft lined by conserved residues important for catalysis and

Background. Angiogenesis has a key role in several conditions and is regulated by several factors such as the platelet-derived growth factor (PDGF) or the vascular endothelial growth factor (VEGF). The goal of this study was to investigate the possible role of PDGF and VEGF in a group of patients with severe food allergy. Methods. We design a prospective longitudinal study (n = 30) with patients w

Background: Models describing nuclear fragmentation and fragmentation fission deliver important input for planning nuclear physics experiments and future radioactive ion beam facilities. These models are usually benchmarked against data from stable beam experiments. In the future, two-step fragmentation reactions with exotic nuclei as stepping stones are a promising tool for reaching the most neut

Addressing sustainability concerns in supply chain operations can be a matter of long-term business survival for food retailers. However, regardless of whether it is perceived as a risk or market opportunity, acting across the value chain to address unsustainable production and consumption practices has been a constant challenge. This thesis investigated the sustainable supply chain management (SS

Pump-based Parkinson (PD) therapies, including subcutaneous apomorphine infusion (CSA) and levodopa-carbidopa intestinal gel (LCIG), presently constitute the most effective pharmacological treatments available for advanced PD. These therapies are based on a more constant delivery of the dopaminergic drug resulting in a more continuous dopaminergic stimulation and a more stable treatment effect. Th

Nonintrusive methods for characterizing food products are of increasing interest related to the greater awareness of food safety issues. Hen eggs are an important part in food consumption in most parts of the world. We have investigated an optical method utilizing tunable diode lasers for monitoring free gas in eggs. We show that oxygen signals, recorded around 760nm, increase steadily as eggs bec

Compared to conventional color Doppler ultrasound imaging, the new color Doppler modality "color Doppler energy" (CDE) has improved the possibility of visualizing blood vessels having low blood-flow velocities, but appears to be influenced by the settings of the ultrasound instrument and motion artefacts. The aim of this methodological study was to evaluate the effects of the different factors on

Europaparlamentets och rådets direktiv 2012/13/EU om rätten till information vid straffrättsliga förfaranden utgör en del i en färdplan inom EU att förstärka rättighetsskyddet för misstänkta personer i brottmålsförfaranden. Artikel 7.1 i direktivet införlivades med svensk rätt den 1 juni 2014 genom införandet av 24 kap. 9 a § rättegångsbalken. Enligt artikel 7.1 i direktivet ska den som frihetsberDirective 2012/13/EU on the right to information in criminal proceedings (the Directive) is part of a road map within EU to strengthen the protection of rights of suspects in criminal proceedings. Article 7.1 of the Directive was implemented in Swedish procedural legislation on June 1st 2014 through a new statutory provision in the Swedish Code of Judicial Procedure, 24 kap. 9 a §. According to Ar

This master’s thesis report describes the development of a new system for control and monitoring of a helium liquefaction plant which has been carried out at Kryolab, Lund University. At the plant, helium gas is purified and then cooled in several steps until it condensates. The plant is very similar to the ones constructed today, but Kryolab wished to replace the outdated control system. The new

Som följd av klimatförändringar kommer klimatanpassningsåtgärder att bli nödvändiga för att skydda mot effekterna av det förändrade klimatet. Det förändrade klimatet kommer innebära att risken för översvämningar och erosion ökar längs med Sveriges kuster, sjöar och vattendrag. Vem det är som bär ansvaret för att se till att dessa klimatanpassningsåtgärder kommer till stånd råder det en osäkerhet kAs a result of climate change, our society will need to start to adapt to the changing conditions. With these changes the risk of floods, races, spills and erosion along the coasts, lakes and streams of Sweden will increase. The need to take action to counteract these impending risks is strong but how is going to take responsibility for these actions? The purpose of the report is to investigate th

Continuous Delivery (CD) has today become an essential part of software development for a reliable and automated quality assurance process. However, the challenge of introducing CD starts with setting up a CD pipeline and providing the necessary infrastructure for it, which may take a considerable amount of time and require expertise knowledge. This complex and costly implementation will also requ