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Disease gene identification is still a challenge despite modern high-throughput methods. Many diseases are very rare or lethal and thus cannot be investigated with traditional methods. Several in silico methods have been developed but they have some limitations. We introduce a new method that combines information about protein-interaction network properties and Gene Ontology terms. Genes with high

Popular Abstract in Swedish Alla kemikalier vi använder oss av och utsätter oss för påverkar både oss och den omvärld vi lever i. Under hela sin livscykel har de en påverkan på miljön, från de att man utvinner råmaterialen, när de tillverkas och när vi använder dem. Till och med efter att vi använt dem har kemikalierna en påverkan på miljön. Det gäller både schampot som följer med duschvattnet ut It is of at most importance that society reduces its impact on the environment. In the chemical industry the use of renewable resources will play a fundamental role in the transition to more sustainable chemical products. Also industrial biotechnology, i.e. the use of enzymes to convert raw material into valuable chemicals at low temperatures, leads to more sustainable processes. The research pres

Background. Neisseria meningitidis (Nm) is a Gram negative diplococcus causing bacterial meningitis and fulminant septicemia. In order to allow efficient characterization of infecting strains, antibody reagents for use as analytical tools have proven to be invaluable tools. Similarly, antibodies against relevant bacterial antigens may guide in the selection of components to be included in developi

BACKGROUND: In a previous study, we reported an increased prevalence of thyroperoxidase antibodies (TPOA) in patients with bipolar disorder. Here we report the prevalence of other organ-specific autoantibodies: H/K adenosine triphosphatase (ATPA), glutamic acid decarboxylase-65 (GAD65A), and GAD-67 (GAD67A). METHODS: ATPA, GAD65A, and GAD67A were determined (via a commercially available enzyme lin

Fuel cells, redox flow batteries and some water desalination technologies such as reverse osmosis and electrodialysis require efficient ion exchange membranes to perform in an optimum way. Thus, by enhancing the properties of these membranes there is a possibility to improve this type of applications and technologies. Depending on the specific application, anion or proton exchange membranes with g

Microsoft Word - Mitchell Thorn Dikec Urban Uprisings (final 7 September 2018) red TG 1  Swedish National Program in Human Geography PhD Education      PhD Course in Urban Geography/Urban Studies/Cultural Studies:    “Riots, Uprisings, and Revolts in the Contemporary City”    Fall, 2018, 7.5 ECTS      Course Organizers:  Prof. Don Mitchell, Department of Social and Economic Geography, Uppsala Univ

https://www.keg.lu.se/sites/keg.lu.se/files/nationella_forskarkurser_-_urban_uprisings_2018.pdf - 2026-05-20

The harvest mouse Micromys minutus has, through nest findings, been documented to live in wetlands in tall sedges and grasses in Central Europe. However, there is very little information on the type of habitat this species uses outside of nesting, because this rodent is difficult to capture in ordinary trapping set-ups. In France and Switzerland, the harvest mouse populations have decreased strong

The aim of the present work is to introduce an innovative framework for employing 3D-GIS as an exploratory platform to perform visual analysis. Such a methodology is aimed at detecting patterns of visibility to simulate the past human perception of specific categories of artifacts placed inside a virtually reconstructed three-dimensional space. As a case study, the house of Caecilius Iucundus in P

Objective: To evaluate if the measurement of survivin in the blood of patients with rheumatoid arthritis (RA) undergoing infliximab treatment has predictive value for treatment response. Methods: The study included 87 consecutive RA patients (age 24-89 years, disease duration 18-526 months) treated with regular infusions of influximab. Survivin levels were measured by enzyme-linked immunosorbent a

Ovarian cancer linked to Lynch syndrome represents a rare subset that typically presents at young age as early-stage tumors with an overrepresentation of endometrioid and clear cell histologies. We investigated the molecular profiles of Lynch syndrome-associated and sporadic ovarian cancer with the aim to identify key discriminators and central tumorigenic mechanisms in hereditary ovarian cancer.

Parkinson disease (PD) is characterized by loss of the A9 nigral neurons that provide dopaminergic innervation to the striatum. This discovery led to the successful instigation of dopaminergic drug treatments in the 1960s, although these drugs were soon recognized to lose some of their efficacy and generate their own adverse effects over time. Despite the fact that PD is now known to have extensiv

Somatic hypermutation (SHM) features in a series of 1967 immunoglobulin heavy chain gene (IGH) rearrangements obtained from patients with chronic lymphocytic leukemia (CLL) were examined and compared with IGH sequences from non-CLL B cells available in public databases. SHM analysis was performed for all 1290 CLL sequences in this cohort with less than 100% identity to germ line. At the cohort lev

The self-incompatible composite Senecio Jacobaea (ragwort) exhibits geographic variation in the frequency of rayed and discoid (rayless) individuals. Hybrid progenies from within- and between-morph crosses were established in a seminatural (garden) environment to determine whether patterns of segregation conform to single-gene predictions (as found in other Senecio species), whether the direction

Error estimation and data fusion are critical to improving the accuracy of global model- and satellite-based precipitation products for practical applications. However, they face challenges over vast areas of the world due to limited ground observations. Triple collocation (TC) method can overcome this limitation and provide an efficient way for error estimation without the “ground truth” and thus

Even though floral scent is of major importance for pollinator attraction, it is less investigated than other floral traits. Previous studies suggest the importance of joint exploration of olfactory and visual floral cues to understand plant–pollinator interactions. We investigated flower scents in Collinsia heterophylla, a bee-pollinated, annual herb a with mixed-mating system combining self- and

We present the X-ray spectroscopic study of the Compton-thick (CT) active galactic nuclei (AGN) population within the Chandra Deep Field South (CDF-S) by using the deepest X-ray observation to date, the Chandra 7 Ms observation of the CDF-S. We combined an optimized version of our automated selection technique and a Bayesian Monte Carlo Markov chains (MCMC) spectral fitting procedure, to develop a

Left ventricular assist devices (LVADs) have dramatically improved short-term outcomes among patients with advanced heart failure. While neurohormonal blockade (NHB) is the cornerstone of treatment for patients with heart failure with reduced ejection fraction, its effect after LVAD placement has not been established. We reviewed medical records of 307 patients who underwent primary LVAD implantat

Diamond anvil cell techniques have been improved to allow access to the multimegabar ultrahigh-pressure region for exploring novel phenomena in condensed matter. However, the only way to determine crystal structures of materials above 100 GPa, namely, X-ray diffraction (XRD), especially for low Z materials, remains nontrivial in the ultrahigh-pressure region, even with the availability of brillian

Artificial intelligence (AI) algorithms for automated classification of skin diseases are available to the con-sumer market. Studies of their diagnostic accuracy are rare. We assessed the diagnostic accuracy of an open-access AI application (Skin Image Search™) for recognition of skin diseases. Clinical images including tumours, infective and inflammatory skin diseases were collected at the Depart