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Predicting the survival of patients with peritoneal carcinomatosis of colorectal origin treated by aggressive cytoreduction and hyperthermic intraperitoneal chemotherapy

BACKGROUND: Peritoneal carcinomatosis in the absence of distant metastasis occurs in approximately 8 per cent of patients with colorectal cancer. Cytoreduction followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is a new treatment option. Patient selection is crucial to outcome.METHODS: Cytoreduction followed by HIPEC was performed in 102 patients with peritoneal carcinomatosis. The foll

Vertebral Hemangiomas : Prevalence, New Classification and Natural History. Magnetic Resonance Imaging-Based Retrospective Longitudinal Study

Background and purpose: To determine the prevalence of vertebral hemangiomas (VHs), establish a new classification of VHs based on their MRI-signal pattern, and study their natural history. Methods: MRI of 1000 consecutive patients who underwent at least two MRI with an interval of at least 3 years. Growth rate and change of MRI-signal pattern during the follow-up period were the parameters includ

Perceived usefulness of trauma audit filters in urban India : a mixed-methods multicentre Delphi study comparing filters from the WHO and low and middle-income countries

OBJECTIVE: To compare experts' perceived usefulness of audit filters from Ghana, Cameroon, WHO and those locally developed; generate context-appropriate audit filters for trauma care in selected hospitals in urban India; and explore characteristics of audit filters that correlate to perceived usefulness.DESIGN: A mixed-methods approach using a multicentre online Delphi technique.SETTING: Two large

The effect of a tight control regime with monthly follow-up on remission rates and reported pain in early rheumatoid arthritis

Objective: To determine whether a tight control (TC) regime with monthly consultations to the physician for the first 6 months, could increase remission rate and improve reported pain of patients with early rheumatoid arthritis (RA). Methods: In this single-centre, TC study, with monthly visits to the physician, a cohort of 100 patients with early RA was consecutively included. They were compared

Extensive transgressive gene expression in testis but not ovary in the homoploid hybrid Italian sparrow

Hybridization can result in novel allelic combinations which can impact the hybrid phenotype through changes in gene expression. While misexpression in F1 hybrids is well documented, how gene expression evolves in stabilized hybrid taxa remains an open question. As gene expression evolves in a stabilizing manner, break-up of co-evolved cis- and trans-regulatory elements could lead to transgressive

Prenatal Exposure to Locally Emitted Air Pollutants Is Associated with Birth Weight: : An Administrative Cohort Study from Southern Sweden

While prenatal exposure to ambient air pollution has been shown to be associated with reduced birth weight, there is substantial heterogeneity across studies, and few epidemiological studies have utilized source-specific exposure data. The aim of the present study was, therefore, to investigate the associations between local, source-specific exposure to fine particulate matter (PM2.5) during pregn

Workers building the People’s Park: experiments in movement-made leisure spaces in 19th century

Parks and other public spaces play an important role in working class formation. Yet, these placeswere often provided for urban populations by philanthropic elites who in turn set the, oftenunambiguously authoritarian, terms of use. In the Swedish city Malmö, the social democratic labormovement acquired a public park run by the movement itself in 1893 and proclaimed it “ThePeople’s Park”, mimickin

Adverse events associated with microsurgial treatment for ruptured intracerebral aneurysms : A prospective nationwide study on subarachnoid haemorrhage in Sweden

Background Adverse events (AEs) or complications may arise secondary to the treatment of aneurysmal subarachnoid haemorrhage (SAH). The aim of this study was to identify AEs associated with microsurgical occlusion of ruptured aneurysms, as well as to analyse their risk factors and impact on functional outcome. Methods Patients with aneurysmal SAH admitted to the neurosurgical centres in Sweden wer

Carboligation of 5-(hydroxymethyl)furfural via whole-cell catalysis to form C12 furan derivatives and their use for hydrazone formation

BACKGROUND: Biobased 5-(hydroxymethyl)furfural (5-HMF) is an important platform that offers numerous possibilities for upgrading to a range of chemical, material and fuel products. One reaction of special interest is the carboligation of 5-HMF into C 12 compounds, including 5,5'-bis(hydroxymethyl)furoin (DHMF) and its subsequent oxidation to 5,5'-bis(hydroxymethyl)furil (BHMF), due to their potent

The Importance of Perceived Barriers to Women Entering and Advancing in Orthopaedic Surgery in the US and Beyond

BACKGROUND: Global perceptions of barriers to women in orthopaedics have not been assessed. The purpose of this study was to determine the importance of international barriers to women entering and advancing within orthopaedic surgery.METHODS: An anonymous, online survey was distributed to women medical students, trainees, and practicing surgeons via Women in Orthopaedics Worldwide, the "Women in

B-type natriuretic peptide is predictive of postoperative events in orthopedic surgery

BACKGROUND: [Corrected] Clinical assessment is not always sufficient to predict postoperative (PO) cardiac complications. B-type natriuretic peptide (BNP) has an important prognostic value in patients with heart failure. Its value as a predictor of events in orthopedic surgeries has not yet been tested.OBJECTIVE: To assess the value of BNP in predicting cardiac complications in the PO period of or

Access to psychological treatment for chronic cancer-related Pain in Sweden

ObjectivesCancer related pain (CRP) is among the most frequent collateral effects of cancer, with chronic CRP, lasting at least three months, affecting >40% of cancer survivors.Evidence based treatments, including pain-focused Cognitive Behavioral Therapy(CBT) are available, but it appears that cancer patients/survivors are often poorlyinformed about CRP or the potential benefits of CBT for such p

Rethinking Gender in Orthodox Christianity

What is the role of gender in Eastern Christianity? In this volume, Orthodox experts of different disciplines and cultural backgrounds tackle this complex question. They engage critically with gender issues within their own tradition. Rather than simply accepting pervasive assumptions and practices, the authors challenge readers to reconsider historically or theologically justified views by offeri

Can active sun exposure decrease the risk of giant cell arteritis and polymyalgia rheumatica in women?

ObjectivesTo study if active sun exposure among women affects the risk of developing GCA or PMR in a prospective cohort study with restricted latitudinal variability.MethodsWe linked the response to questions relating to sun exposure from the Melanoma Inquiry in Southern Sweden (MISS) prospective cohort study in women to the risk of developing GCA or PMR. Healthcare data were gathered from the Skå

Disfluencies in spontaneous speech in persons with low-grade glioma before and after surgery

Impaired lexical retrieval is common in persons with low-grade glioma (LGG). Several studies have reported a discrepancy between subjective word-finding difficulties and results on formal tests. Analysis of spontaneous speech might be more sensitive to signs of word-finding difficulties, hence we aimed to explore disfluencies in a spontaneous-speech task performed by participants with presumed LGG

A Reconfigurable RF Filter With 1%–40% Fractional Bandwidth for 5G FR1 Receivers

This letter presents a radio frequency front-end (RFFE) for 5G new radio (NR) receivers operating in frequency range 1 (FR1). The core of this RFFE is a synthetic fourth-order Q -enhanced RF filter employing gm -boosting, noise-canceling, capacitive cross-coupling, and forward body-biasing techniques to achieve 1.7 to 6.4 GHz operating range and 1% to 40% adjustable fractional bandwidth (FBW). The

Social Infrastructure and the Alleviation of Loneliness in Europe

In Europe, individualist societies, in which people more highly value independence, have fewer people who are lonely. Yet these societies also have more people who live alone, a strong determinant of loneliness. Evidence suggests that some unrecognized societal-level resources or characteristics can explain this.We uncover multiple pathways toward a lower degree of loneliness among European societ

Identification of Asthma Phenotypes in the Spanish MEGA Cohort Study Using Cluster Analysis

Introduction: The definition of asthma phenotypes has not been fully established, neither there are cluster studies showing homogeneous results to solidly establish clear phenotypes. The purpose of this study was to develop a classification algorithm based on unsupervised cluster analysis, identifying clusters that represent clinically relevant asthma phenotypes that may share asthma-related outco