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A New SITA Perimetric Threshold Testing Algorithm : Construction and a Multicenter Clinical Study

Purpose: To describe a new time-saving threshold visual field–testing strategy—Swedish Interactive Thresholding Algorithm (SITA) Faster, which is intended to replace SITA Fast—and to report on a clinical evaluation of this new strategy. Design: Description and validity analysis for modifications applied to SITA Fast. Methods: Five centers tested 1 eye of each of 126 glaucoma and glaucoma suspect p

Design and development of nanoimprint-enabled structures for molecular motor devices

Devices based on molecular motor-driven cytoskeletal filaments, e.g., actin filaments, have been developed both for biosensing and biocomputational applications. Commonly, these devices require nanoscaled tracks for guidance of the actin filaments which has limited the patterning technique to electron beam lithography. Thus, large scale systems become intractable to fabricate at a high throughput

Double-crossed polarization transient grating for distinction and characterization of coherences

Coherent phenomena have been widely suggested to play a role in efficient photosynthetic light harvesting and charge separation processes. To substantiate these ideas, separation of intramolecular vibrational coherences from purely electronic or mixed vibronic coherences is essential. To this end, polarization-controlled two-dimensional electronic spectroscopy has been shown to provide an effectiv

Time-Stretched Spectroscopy by the Quantum Zeno Effect : The Case of Auger Decay

A tenet of time-resolved spectroscopy is "faster laser pulses for shorter timescales". Here, we suggest turning this paradigm around, and slowing down the system dynamics via repeated measurements, to do spectroscopy on longer timescales. This is the principle of the quantum Zeno effect. We exemplify our approach with the Auger process, and find that repeated measurements increase the core-hole li

Four-Majorana qubit with charge readout : Dynamics and decoherence

We present a theoretical analysis of a Majorana-based qubit consisting of two topological superconducting islands connected via a Josephson junction. The qubit is operated by electrostatic gates which control the coupling of two of the four Majorana zero modes. At the end of the operation, readout is performed in the charge basis. Even though the operations are not topologically protected, the pro

Luminescent Intermediates and Humidity-Dependent Room-Temperature Conversion of the MAPbI3 Perovskite Precursor

Preparation of metal-halide perovskites under room temperature attracts attention because of energy saving by removing thermal annealing. Room-temperature transformation of spin-cast wet films consisting of methylammonium (MA) iodide, PbI2, and dimethylformamide toward solid MAPbI3 perovskite proceeds via several intermediate crystalline states and is strongly dependent on ambient humidity. Light

Nanoscale quantum calorimetry with electronic temperature fluctuations

Motivated by the recent development of fast and ultrasensitive thermometry in nanoscale systems, we investigate quantum calorimetric detection of individual heat pulses in the sub-meV energy range. We propose a hybrid superconducting injector-calorimeter setup, with the energy of injected pulses carried by tunneling electrons. It is shown that the superconductor constitutes a versatile injector, w

Associations between autoimmune conditions and hepatobiliary cancer risk among elderly US adults

Growing evidence suggests that people with autoimmune conditions may be at increased risk of hepatobiliary tumors. In the present study, we evaluated associations between autoimmune conditions and hepatobiliary cancers among adults aged ≥66 in the United States. We used Surveillance, Epidemiology, and End Results (SEER)-Medicare data (1992–2013) to conduct a population-based, case–control study. C

A new look at effective interactions between microgel particles

Thermoresponsive microgels find widespread use as colloidal model systems, because their temperature-dependent size allows facile tuning of their volume fraction in situ. However, an interaction potential unifying their behavior across the entire phase diagram is sorely lacking. Here we investigate microgel suspensions in the fluid regime at different volume fractions and temperatures, and in the

Estimation of HIV incidence and its trend in three key populations in Iran

In Iran, People Who Inject Drugs (PWID), Female Sex Workers (FSW), and prisoners are the main key populations at risk of HIV infection. This study aimed to evaluate the trend of HIV incidence among PWID, FSW and prisoners as an impact measure of HIV harm reduction and prevention efforts in Iran. Data were obtained from the two rounds of national bio-behavioral surveillance surveys among FSW (2010

Nanowire photodetectors with embedded quantum heterostructures for infrared detection

Nanowires offer remarkable opportunities for realizing new optoelectronic devices because of their unique fundamental properties. The ability to engineer nanowire heterostructures with large bandgap variations is particularly interesting for technologically important broadband photodetector applications. Here we report on infrared photodetectors based on arrays of InP nanowires with embedded InAsP

Temperature characterization of an operando flow reactor for heterogeneous catalysis

In this work, we present several methods to determine the temperature of a catalyst sample, as well as the gas surrounding it, in a typical flow reactor used for operando research on heterogeneous catalysis. To determine the sample temperature, we present an approach using calibrated IR-camera imagery, as well as thermographic phosphors. For the gas temperature, we present methods to extract tempe

Red-Shifted Photoluminescence from Crystal Edges Due to Carrier Redistribution and Reabsorption in Lead Triiodide Perovskites

Photoluminescence (PL) of CH 3 NH 3 PbI 3 perovskites depends strongly on sample preparation, atmosphere, crystal size, and so forth. However, the origin of these dependencies is always misunderstood because of the co-works of many different factors. Herein, we prepared hexagonal-shaped single crystals with tens of micrometers in size and observed a red-shifted PL emission (800-830 nm) mainly

Two-photon excitation spectroscopy of 1,5–Diphenyl-1,3,5-hexatriene using phase modulation

We have used two-photon Fourier transform spectroscopy to investigate the first singlet excited state (S1) of a prototypical polyene molecule 1,5—Diphenyl-1,3,5-hexatriene. As the S1 state in the polyenes is a one-photon forbidden transition, the structure of its vibrational levels cannot be studied using resonant linear excitation. Although this level is accessible with two-photon excitation, pre

Soluble CD163 and TWEAK in early pregnancy gestational diabetes and later glucose intolerance

Gestational diabetes mellitus (GDM) is today universally diagnosed during late pregnancy. Treating hyperglycaemia during pregnancy reduces the risk of complications, the effect of interventions is however limited due to the late diagnosis. It is thus important to identify biomarkers reaching a high precision for GDM development in early pregnancy. Here we aim to investigate soluble CD163 (sCD163)

Thrombocytopenia in bacteraemia and association with bacterial species

Thrombocytopenia is common in patients with invasive bacterial infections. Bacteria can activate platelets, but it is unclear if this affects platelet count. The aim of this study was to examine whether bacteraemia with Staphylococcus aureus, which readily activate human platelets, was more likely to be complicated by thrombocytopenia than bacteraemia with Escherichia coli or Streptococcus pneumon

Associations of cigarette smoking with disease phenotype and type I interferon expression in primary Sjögren's syndrome

Several studies have shown a negative association between smoking and primary Sjögren's syndrome (pSS), and smoking may interfere with the immune response. The purpose of this study was to investigate if smoking affects disease activity and disease phenotype in pSS. In this cross-sectional study, consecutive pSS patients filled out the EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI) form