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Ligands usually bind to proteins by displacing water from the binding site. The affinity and kinetics of binding therefore depend on the hydration characteristics of the site. Here, we show that the extreme case of a completely dehydrated free binding site is realized for the large nonpolar binding cavity in bovine beta-lactoglobulin. Because spatially delocalized water molecules may escape detect

Water–biomolecule interactions have been extensively studied in dilute solutions, crystals, and rehydrated powders, but none of these model systems may capture the behavior of water in the highly organized intracellular milieu. Because of the experimental difficulty of selectively probing the structure and dynamics of water in intact cells, radically different views about the properties of cell wa

Swedish cross-sectional survey data on young individuals aged 12-18-year-old was used to analyse school-class based peer effects in binge drinking, smoking and illicit-drug use. Significant and positive peer effects were found for all three activities. By introducing school/grade fixed effects, the estimated peer effects were identified by variation in peer behaviour across school-classes within s

Today many methods are available for gas turbine flow path analysis. Some of them are very simple but yet very useful, since they give an indication of the compressor capacity with almost no calculation effort. The state of the art today is the heat and mass balance models (HMB), which are more sophisticated. This paper presents a general overview of these methods, including the most recent trend,

The first model to predict chloride ingress into concrete was presented by Collepardi in 1970, in Italian! That model was used for some 20 years for design of concrete structures before it was realized that the main parameter, the apparent chloride diffusion coefficient, is not a material property! Since then the Collepardi model has been significantly improved and developed into more or less soph

OBJECTIVE: To compare costs of transurethral prostatic resection (TURP) and transurethral microwave thermotherapy (TUMT) for symptomatic benign prostatic hyperplasia (BPH) in a randomized, controlled trial. METHODS: In 70 BPH patients all costs were calculated for management, including complications and repeat treatment, during TURP or TUMT and 24-month follow-up. Clinical outcome was judged from

Abstract When studying the deposition of particles in wind tunnel experiments, we measure theairborne particles with an Aerodynamic Particle Sizer (APS). The deposited particles are examined with an optical microscope connected to an image analyzer. Calibration between the APS and the optical microscope determinations of particle size has been performed for particles of fused alumina. The particle

This paper suggests reasons why an organisation starts the process of reorganising software applications hosting and how these reasons are connected with resilience in software applications used and in business processes. The decision investigated is a sourcing decision process in a Swedish municipality. The main reason for starting the sourcing decision process was that the municipality needed to

OBJECTIVE:: To evaluate the prognostic implication of changes in postoperative B-type natriuretic peptide (BNP) concentrations in patients undergoing cardiopulmonary bypass for cardiac surgery. DESIGN:: A retrospective analysis of prospectively collected clinical data. SETTING:: Cardiothoracic surgery and an intensive care unit (ICU) in a university hospital. PARTICIPANTS:: The present study inclu

Background: Asthma and allergic airway inflammation are associated with persistent structural alterations in the bronchi, i.e. airway remodeling. Previous studies have shown that during allergic airway inflammation, similar structural alterations may also be evoked in the pulmonary circulation. However, it remained unknown whether remodeling of the pulmonary circulation is as persistent as airway

The aim was to investigate the construct validity and internal consistency of the Swedish version of the Consumer Emergency Care Satisfaction Scale. The sample comprised 157 persons from an emergency department and an observation ward. The results showed satisfactory reliability, and an explorative factor analysis revealed 3 factors: Caring, Teaching, and Clinical Competence. The Swedish version o

New radiative lifetime measurements performed with time-resolved laser spectroscopy for the 6p(1/2) and 6p(3/2) levels of La III provide a unique opportunity for testing the adequacy of the relativistic Hartree-Fock approach for atomic structure calculations in this ion. As a consequence of the comparison, an extensive set of accurate f-values is provided for many La III and Lu III UV and visible