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Indistinguishable genomic profiles and shared prognostic markers in undifferentiated pleomorphic sarcoma and leiomyosarcoma: different sides of a single coin?

Soft tissue sarcoma (STS) diagnostics and prognostics are challenging, particularly in highly malignant and pleomorphic subtypes such as undifferentiated pleomorphic sarcoma (UPS) and leiomyosarcoma (LMS). We applied 32K BAC arrays and gene expression profiling to 18 extremity soft tissue LMS and 31 extremity soft tissue UPS with the aim of identifying molecular subtype signatures and genomic prog

Bet on both sides of the coin to improve the organizational climate: The impact of congruent task and role clarity between leaders and staff

Four organizations at Stockholm-Arlanda airport are going through various organizational changes. They are preparing for present and future demands through structural changes, implementation of new technology, training, and other efficiency and capacity improving measures. The change processes will be followed during two years of which this paper presents the baseline measurement. The key factors

Two Sides of the Same Coin: Bootstrapping the Restricted vs. Unrestricted Model

The properties of the bootstrap test for restrictions are studied in two versions: 1) bootstrapping under the null hypothesis, restricted, and 2) bootstrapping under the alternative hypothesis, unrestricted. This article demonstrates the equivalence of these two methods, and illustrates the small sample properties of the Wald test for testing Granger-Causality in a stable stationary VAR system by

Fc epsilon RI levels and frequencies of peripheral blood dendritic cell populations in allergic rhinitis

The dendritic cell (DC) lineage encompasses a diverse population of cells with unique subtype-specific functions. In peripheral blood, four DC subsets have been identified based on their distinct expression of CD1c, CD141, CD16, and CD123, and these subpopulations exhibit functional properties in immune responses. However, their respective roles in allergic diseases, such as rhinitis, are unclear.

Two sides of the same green coin? A legal analysis of the concept of the (green) industrial competitiveness of the Union through the Net-Zero Industry Act

I den pågående kampen mot klimathotet har Europeiska unionen antagit en ledande roll för att fullfölja skiftet mot en grön ekonomi, bland annat genom att fokusera på att stärka konkurrenskraften avseende tillverkningen av netto-noll energiindustrin och säkra de nödvändiga råvarorna för denna omställning. För att möjliggöra detta presenterade den Europeiska kommissionen i mars 2023, i samband med pIn the global race against climate change, the answer of the European Union is the transition towards a green economy by focusing on strengthening the competitiveness of the net-zero technology industry and securing the necessary critical materials. To do so, the Union presented two legislative acts in the European Green Deal Industrial Plan in 2023, amongst which the Net-Zero Industry Act. While

Biological and structural characterization of murine TRALI antibody reveals increased Fc-mediated complement activation

Transfusion-related acute lung injury (TRALI) remains a leading cause of transfusionrelated deaths. In most cases, anti-leukocyte antibodies in the transfusion product trigger TRALI, but not all anti-leukocyte antibodies cause TRALI. It has been shown that the anti-major histocompatibility complex (MHC) class I antibody 34-1-2S (anti-H-2Kd) causes TRALI in BALB/c mice (MHC class I haplotype H-2Kd)