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Streptococcus pneumoniae infections remain a major cause of morbidity and mortality worldwide. Therefore a detailed understanding and characterization of the mechanism of host cell colonization and dissemination is critical in order to gain control over this versatile pathogen. Here we identified a novel 72 kDa pneumococcal protein endopeptidase O (PepO), as a plasminogen and fibronectin binding p

Platelets are potent regulators of neutrophil accumulation in septic lung damage. We hypothesized that platelet-derived CXCL4 might support pulmonary neutrophilia in a murine model of abdominal sepsis.

The climatic conditions inside nuclear reactor containments are continuously monitored by the plant owners in order to e.g. maintain a suitable climate for the mechanical and electrical equipment. Due to the high temperatures, during operation, the concrete within the containment may act as a moisture source contributing to the humidity. To evaluate if, and to what extent, the concrete inside the

L-DOPA is currently the standard treatment for alleviating the motor symptoms in Parkinson's disease. The therapeutic efficacy, however, diminishes as the disease progresses. It has been suggested that the beneficial effect of L-DOPA could be reestablished by changing the mode of administration. Indeed, continuous delivery of L-DOPA has been shown to be an effective way to circumvent many of the s

The Gram-positive species Streptococcus pneumoniae is a human pathogen causing severe local and life-threatening invasive diseases associated with high mortality rates and death. We demonstrated recently that pneumococcal endopeptidase O (PepO) is an ubiquitously expressed, multifunctional plasminogen and fibronectin binding protein facilitating host cell invasion and evasion of innate immunity. I

Using scanning electron microscopy guidance, atomically resolved scanning tunneling microscopy investigations inside openings formed during the decomposition of a thick SiO2 film on a Si(111) surface have been performed. We report, for the first time, the presence of Ni atoms inside self-formed openings. The SiO2 decomposition as a function of annealing temperature and time was studied. By compari

One of the key purposes of bone tissue engineering is the development of new biomaterials that can stimulate the body's own regenerative mechanism for patient's anatomical and functional recovery. Bioactive glasses, due to their versatile properties, are excellent candidates to fabricate porous 3-D architectures for bone replacement. In this work, morphological and structural investigations are ca

In occupational therapy and occupational science, it is important to clarify the perspective from which the analysis of occupation is addressed. The purpose of this paper is to present a tentative structure for describing occupation, allowing for analysis in a lifelong panorama as well as for the immediate experience a person acquires from performing a single occupation. The concept of occupationa

In order to support the development of optimal housing options for older people, we need to increase our understanding of relations between aspects of housing and aspects of health in old and very old age. The objective of this cross-sectional study was to explore whether and how aspects of housing are related to life satisfaction and perceived health among very old, single-living Swedish people.

Popular Abstract in DanishLivsbaner gennem et felt viser hvorledes eliteidrætsudøvere klarer sig i samfundet efter livet i sporten. Spørgsmålet er om erhvervelse af fysisk sportskapital i sportsfeltet, medieret gennem berømmelse, medvirker til at opnå et arbejde eller en bestemt placering i samfundet. Sportskapital bidrager måske til social mobilitet. Dette er belyst gennem konkrete undersøgelser The thesis deals with a theoretical outline of the theory of reconversions in the light of the social space, with an analysis of top level athletes' mobility and strategies of reconversions in their trajectories through the relative autonomous field of sports. Some disciplines in this field have much autonomy, others less, and are positioned according to a state of distribution of the specific cap

Helicobacter pylori exists in two different morphological forms, spiral and coccoid. This study demonstrated that both forms can infect BALB/c A mice. The animals were inoculated orally three times at 2-day intervals with 10(8) cfu of both spiral and coccoid forms of strain CCUG 17874 (NCTC 11637), strain 25 and strain 553/93. Infection was followed over a 30-week period by histological scoring of

The processes of multiplication of electronic excitations (MEE), connected with the creation of secondary excitons or electron-hole (e-h) pairs by hot conduction electrons, are realized in wide-gap metal halides and oxides. In oxides, secondary e-h pairs can be also formed by 27-40 eV photons due to L 1 VV Auger transitions (with the participation of 2s oxygen holes). The excitation spectra of lum

Rheumatoid arthritis (RA) is an autoimmune disease characterized by a persistent inflammation of the synovium, leading to the erosion of articular cartilage and bone. Synovial mast cells and their effector molecule, histamine, receive increased attention as mediators of joint inflammation. The aim of our study was to analyse levels of free histamine in serum and joint fluid of RA patients and to e

This article is based on an analysis of Lund University that took place during the summer and autumn of 2004 (available for download at www.iiiee.lu.se, click library and publications). The university had experienced a loss of momentum in their progress regarding environmental issues. The purpose of the study was to identify barriers to including sustainability-related content throughout Lund Univ

Tumor cells secreting IL-1 beta are invasive and metastatic, more than the parental line or control mock-transfected cells, and concomitantly induce in mice general immune suppression of T cell responses. Suppression strongly correlates with accumulation in the peripheral blood and spleen of CD11b(+)/Gr-1(+) immature myeloid cells and hematological alterations, such as splenomegaly, leukocytosis,

Popular Abstract in Swedish Tibet och den tibetanska buddhismen har i väst ofta kommit att användas som synonymer. Tidigt kom landets otillgänglighet och stängda dörrar mot omvärlden att utöva en stark lockelse för resande och religiösa sökare. De kom i många fall att betrakta landet och dess folk som bevarare av en kunskap och vishet som gått den övriga världen förlorad. Föreställningen om den rThis dissertation in anthropology of religion focuses on images of Tibet, among Westerners as well as among Tibetans. Based on approximately one year of fieldwork in the former British Hill station, it also deals with the politics of the Central Tibetan Administration (CTA) and some of its political and social implications for the exiled Tibetan youth living in Dharamsala, India. The Western perc