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As the boundaries of ‘work’ extend to include work that adapts to or brings about new organization, social value and alternative futures, it intersects with entrepreneurship studies in intriguing yet under-developed ways. This special issue focuses on developing this intersection by advancing process and practice theory research on entrepreneuring. Entrepreneuring is a concept that captures the pr
Hypoxia is one of the common effects of eutrophication in coastal marine ecosystems and is becoming an increasingly prevalent problem worldwide. The causes of hypoxia are associated with excess nutrient inputs from both point and non-point sources, although the response of coastal marine ecosystems is strongly modulated by physical processes such as stratification and mixing. Changes in climate, p
Both glial cell line-derived neurotrophic factor (GDNF) and its recently discovered congener, neurturin (NTN), have been shown to exert neuroprotective effects on lesioned nigral dopamine (DA) neurons when administered at the level of the substantia nigra. In the present study, we have explored the relative in vivo potency of these two neurotrophic factors using two alternative routes of administr
Background. Hepatitis C is frequent problem in dialysis wards. Design. A long time (1989-97) follow up of hepatitis C virus (HCV) infection in a Swedish nephrology unit was performed with anti-HCV screening, confirmatory antibody tests, viral RNA detection and molecular characterization. Case histories were reviewed with focus, onset of infection, liver morbidity and mortality. Results. In October
Clinical trials in patients with Parkinson's disease have shown that transplants of fetal mesencephalic dopamine neurons can form a new functional innervation of the host striatum, but the clinical benefits have been highly variable: some patients have shown substantial recovery in motor function, whereas others have shown no improvement and even a worsening in the 3,4-dihydroxyphenyl-L-alanine (L
Class I and class II MHC-restricted T cells specific for proteins present in myelin have been shown to be involved in autoimmunity in the central nervous system (CNS). It is not yet known whether CD1d-restricted T cells reactive to myelin-derived lipids are present in the CNS and might be targeted to influence the course of autoimmune demyelination. Using specific glycohpid-CD1d tetramers and clon
CCAAT/enhancer binding protein (C/EBP)alpha is a myeloid-specific transcription factor that couples lineage commitment to terminal differentiation and cell cycle arrest, and is found mutated in 9% of patients who have acute myeloid leukemia (AML). We previously showed that mutations which dissociate the ability of C/EBP alpha to block cell cycle progression through E2F inhibition from its function
Calcium phosphates have been of great interest in the field of medicine for many decades due to their biocompatibility, hardening properties and diverse areas of application. In this study two different alpha phase tricalcium phosphate powders were produced of distinctly different particle size distributions. These two powders were then tested for reactivity and phase evolution. X-ray diffraction
The integrin CD103 is highly expressed at mucosal sites, but its role in mucosal immune regulation remains poorly understood. We have analyzed the functional role of CD103 in intestinal immune regulation using the T cell transfer model of colitis. Our results show no mandatory role for CD103 expression on T cells for either the development or CD4(+)CD25(+) regulatory T (T reg) cell-mediated contro
To determine the incidence of anterior cruciate ligament (ACL) injuries in the general population; the pathology associated with a knee sprain verified by magnetic resonance imaging (MRI); and the agreement between clinical findings and MRI.Materials and methods: Inclusion criterion was an acute rotational trauma to the knee associated with effusion. One hundred and fifty-nine consecutive patients
In FDCP2 myeloid cells, IL-4 activated cyclic nucleotide phosphodiesterases PDE3 and PDE4, whereas IL-3, granulocyte-macrophage CSF (GM-CSF), and phorbol ester (PMA) selectively activated PDE4. IL-4 (not IL-3 or GM-CSF) induced tyrosine phosphorylation of insulin-receptor substrate-2 (IRS-2) and its association with phosphatidylinositol 3-kinase (PI3-K). TNF-alpha, AG-490 (Janus kinase inhibitor),
This article outlines an experimental and numerical study of the long-term interaction between silica fume and Portland cement in concrete subjected to air, water or sealed curing. For this purpose about 2000 kg of eight qualities of concrete were studied at 4 different ages each over a period of 90 months. Half of the concretes contained silica fume. Parallel studies of strength, hydration and in
The chapter describes and analyses panel data for six villages in Tamil Nadu from 1980 to 2005. It deals with agricultural change and soci-economic improvements.
Against the deeply ingrained belief that technology is instrumental and neutral, this thesis argues that our relation to technology is inextricably bound up with fantasies. But what is the nature of these fantasies and where do we find them? Are they strictly reserved to the domain of Science Fiction, or can we also find them in more mundane contexts, like the business organization? These are som
Popular Abstract in Swedish Balans i vardagens sysslor - en förutsättning för kvinnors hälsa. Psykisk sjukdom och stress anges ofta som orsak till längre sjukskrivning och drabbar kvinnor till övervägande del. Majoriteten av Sveriges kvinnor är idag yrkesarbetande, de tar större ansvar för hem och familj, de arbetar oftare deltid, tar oftare ut ledighet för vård av sjuka barn och utför 65 % mer hThis thesis investigated the concept of balance in daily occupations. The overarching aim was to explore women’s patterns of everyday occupations and to investigate relationships between different aspects of patterns of daily occupations and health and well-being. The participants were working, cohabitant women with pre-school children. The methods used focused on exploring patterns of daily occup
In this paper a methodological approach for the analysis of nonstationary heart rate variability (HRV) signals using time-varying frequency bands based on respiratory frequency is presented. Spectral analysis of HRV is accomplished by means of the Smoothed Pseudo Wigner Ville distribution. Different approaches to the definition of the low frequency (LF) and high frequency (HF) bands are considered
