Sökresultat

Background The etiology of irritable bowel syndrome (IBS) and dysmotility is in most cases unknown. Organic, pathognomonic changes have not been described. We have previously demonstrated sporadic expressions of antibodies against gonadotropin-releasing hormone (GnRH) in serum from these patients. The aim of this study was to screen for the presence of GnRH antibodies in healthy subjects and patie

We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis.

AIMS/HYPOTHESIS: Our aim was to study whether glycaemic control differs between individuals with latent autoimmune diabetes in adults (LADA) and patients with type 2 diabetes, and whether it is influenced by time on insulin therapy. METHODS: We performed a retrospective study of 372 patients with LADA (205 men and 167 women; median age 54 years, range 35-80 years) from Swedish cohorts from Skåne (

Abstract in Undetermined To improve our knowledge of climate change and its impacts on ecosystem services, and to inform local people and governments that need assistance with the development of mitigation and adaptation strategies, climate impacts need to be understood urgently at the smaller scale. On one hand, the microclimate/topoclimate is known to be strongly decoupled from the general macro

In this study, we quantify the effect of uncertainties in climate projections on an impact model (IPS) that describes the temperature-dependent swarming and development of Ips typographus. Three forcing climate data sets (ensembles) were used: (1) E-Obs gridded observations, (2) ERA-40 reanalysis data downscaled by eight regional climate models (RCMs) and (3) regional scenarios from one RCM forced

We explored impacts of climate change on the geographic distribution of European beech by applying state of the art statistical and process-based models, and assessed possible climate change impacts on both adaptive capacity in the centre of its distribution and adaptive responses of functional traits at the leading and trailing edge of the current distribution. The species area models agree that

Objective and methods: Time-use methodologies have been proposed to be established research techniques when exploring aspects of daily occupations. In this study, two graphs illustrating the time arrangement of occupations as they appear in a continuous sequence were used in order to encourage individuals to reflect on their everyday life. The aim was to investigate the usefulness of a time-geogra

Relative to vascular plants, little is known about what factors control bryophyte communities or how they respond to successional and environmental changes. Bryophytes are abundant in boreal forests, thus changes in moss community composition and functional traits (for example, moisture and nutrient content; rates of photosynthesis and respiration) may have important consequences for ecosystem pro

While higher intake of fish and lower consumption of red/processed meats have been suggested to play a protective role in the etiology of several cancers, prospective evidence for hepatocellular carcinoma (HCC) is limited, particularly in Western European populations. The associations of fish and meats with HCC risk were analyzed in the EPIC cohort. Between 1992 and 2010, 191 incident HCC were ide

OBJECTIVE- Some individuals with normal glucose tolerance (NGT) exhibit a 1-h excursion of plasma glucose during oral glucose tolerance testing as high as that of individuals with impaired glucose tolerance (IGT). The aim of this study was to characterize their metabolic phenotype. RESEARCH DESIGN AND METHODS- A total of 1,205 healthy volunteers (aged 29-61 years) underwent assessment of 1) oral g

Emerging technologies allow the high-throughput profiling of metabolic status from a blood specimen (metabolomics). We investigated whether metabolite profiles could predict the development of diabetes. Among 2,422 normoglycemic individuals followed for 12 years, 201 developed diabetes. Amino acids, amines and other polar metabolites were profiled in baseline specimens by liquid chromatography-tan

The main aim of this paper is to study land-atmosphere exchange of carbon dioxide (CO2) for semi-arid savanna ecosystems of the Sahel region and its response to climatic and environmental change. A subsidiary aim is to study and quantify the seasonal dynamics in light use efficiency (epsilon) being a key variable in scaling carbon fluxes from ground observations using earth observation data. The n

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously

Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to longevity in a large cohort of men and women followed for up to 20 years. We find that, higher concentrations of the citric acid cycle intermediate, isocitrate, and the bile acid, ta

Phenological models have mainly been developed to capture the seasonal development of individual trees and local populations, using data from meteorological stations. Ecosystem models that incorporate phenology are however commonly driven by gridded climate data. Using two phenological models to simulate budburst of birch in Germany, we assessed how combining phenological point observations with g

Type 2 diabetes is highly prevalent in immigrants to Sweden from Iraq, but the prevalence of cardiovascular disease (CVD) and its risk factors are not known. In this survey we aimed to compare the prevalence of CVD and CVD-associated risk factors between a population born in Iraq and individuals born in Sweden.

Plant communities differ in their species composition, and, thus, also in their functional trait composition, at different stages in the succession from arable fields to grazed grassland. We examine whether aerial hyperspectral (414–2501 nm) remote sensing can be used to discriminate between grazed vegetation belonging to different grassland successional stages. Vascular plant species were recorde