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Brain and cellular alterations caused by CYP27A1 deficiency in mouse and human models

Förändringar i hjärnan vid avsaknad av CYP27A1 CYP27A1 är en gen vars färdiga protein är involverat i nedbrytning av kolesterol och gallsyrasyntes. Avsaknad av CYP27A1 eller produktion av en dysfunktionell variant av proteinet i människor resulterar i sjukdomen Cerebrotendinös xantomatos (CTX). CTX är en sjukdom som karaktäriseras av grumling av ögats lins, lipidinlagringar i form av knutor i senCYP27A1 is an important enzyme in cholesterol catabolism and bile acid biosynthesis. Deficiency of this enzyme in human leads to the disease Cerebrotendinous xanthomatosis (CTX), which is a recessively inherited lipid storage disorder characterized by symptoms such as cataracts, tendon xanthomas and progressive neurological syndrome. The underlying cause for the neurological symptoms is not well u

The relationship between extramural English exposure and receptive vocabulary knowledge of young Swedish L2 learners of English

Abstract This study examines if extramural English (EE) has a positive effect on L2 vocabulary acquisition of young Swedish L2 learners (N = 24) of English (age 8-10). It examines the correlation between the amount of time spent on EE and scores on the Picture Vocabulary Size Test (PVST), which measures receptive vocabulary knowledge. Since earlier research on older Swedish L2 learners of English

Translating principles of adaptability and flexibility into practice: The case of Swedish Strategic Partnership Organizations' development cooperation with the Eastern Partnership

The donor community has increasingly acknowledged the principles of adaptability and flexibility as part of promoting development cooperation effectiveness. However, limited research has investigated the implementation of these principles, particularly by intermediary civil society organizations (CSOs). Wishing to address these gaps, this thesis examines the implementation of the principles by Swe

Havet: en attraktiv sårbarhet

The sea level is rising and putting infrastructure and people living by the coast at risk, yet there is a global trend of waterfront redevelopment, where cities and municipalities choose to turn old harbors into attractive housing and offices despite the fact that this increases their vulnerability to flooding. The aim of this paper is to understand why Swedish municipalities decide to redevelop o

Skatteflykt genom koncernbidrag och internprissättning - En studie av skatteundvikande förfaranden

Den här uppsatsen handlar om hur bolag i en intressegemenskap gör värdeöverföringar mellan varandra i form av koncernbidrag samt internprissättning. På grund av skatteflyktsbestämmelsers vaghet kan bolag inte direkt förutse om ett förfarande är skatteflykt. Koncernbidrag kan göras avdrag på om det uppfyller de kraven som finns i 35 kap inkomstskattelagen. Dock kan skatteflyktslagen fortfarandThis essay is about how companies in a community of interest make value transfers between each other in the form of group contributions and transfer pricing. Due to the vagueness of Swedish tax evasion regulations, companies can not directly predict when a transaction is considered tax evasion. Group contributions can be deducted from a companies income but only if the comany meets the requir

Barriers and Drivers Influencing the Commercialization of Sustainable Innovations - A Case Study on Skosh

The sociotechnical systems that present societies operate within fail to address sustainability which contributes to the exacerbation of environmental, societal, and economic injustices. Sustainable innovations are considered a potential solution pathway. Nevertheless, to have large scale impact, they need to commercialize successfully. Scholars agree that sustainable business models are essential

Exploring a Two Higgs Doublet Model with a U(1) Family Symmetry and a Complex Singlet

Den så kallade standardmodellen har länge betraktats som en av den moderna vetenskapens triumfer, tack vare dess oerhört exakta förutsägelser, som gång på gång har verifierats av experiment. Men från dess begynnelse har den alltid varit inkomplett: inte nog med att gravitationen, den kraft som vi människor är mest bekanta med, inte ens inkluderas i den så har olika, tidigare okända fenomen blivit In this project a two Higgs doublet model with a complex singlet and an extra family symmetry providing a mechanism for suppression of flavor changing neutral currents is explored. The goal is to investigate the phenomenological consistency of the model using a custom software framework. To this end, the scalar and Yukawa sectors of this extension of the Standard Model are explored in detail. The

Immaterialrättsliga skyddsmöjligheter för objekt med teknisk funktion

Denna uppsats undersöker möjligheten att erhålla skydd för objekt med teknisk funktion utanför patenträtten. Det är patenträtten som vanligtvis förknippas med teknisk funktion baserat på dess ämnessfär och faktiska kvalifikationskrav. Varumärkesrätten har ett väldigt strängt förhållningssätt mot att tillåta att tekniska funktioner erhåller varumärkesskydd. Det finns ett absolut registreringshinderThis thesis examines the possibility of obtaining intellectual property protection for objects with a technical function, beyond the patent rights. The patent is commonly associated with technical function due to its subject and qualification requirements. The trademark law has a strict approach in terms of including technical function in the scope of protection. Through an absolute ground of refu

Svensk praxis om private enforcement - En undersökning av gällande praxis vid rättsfall som prövar civilrättslig konkurrensrättsligt grundad skadeståndstalan, även kallat private enforcement

Uppsatsen undersöker praxis som rör private enforcement (möjligheten till civilrättsligt skadestånd för en privat aktör för överträdelse av konkurrensrätten) i Sverige. Detta görs genom att studera de rättsfall som har hanterats av svenska domstolar, samt genom att se till de viktigaste rättsfallen inom EU-rätt. I en analys av detta ser man att området är outforskat i svensk praxis med få rättsfal

Profitable Sustainability

This thesis investigates the sustainability discourse present in two urban development projects in Malmö. The projects investigated are Sege Park in Kirseberg, and Culture Casbah in Rosengård. The City of Malmö has profiled itself as seriously invested in sustainable urban development, but it is evident that the sustainability focus is different when applied to different parts of the city. To unde

Singular Value Decomposition as a Method for Analyses and Forecasts of Financial Data

This paper examines the sufficiency of a trading method based on singular value decomposition (SVD) of past stock prices. The SVD method is frequently used as a tool to reduce data noise, compress big-data, and analyse data components. Hence, the method is well suited to form a ground for a predictive tool of price developments. From the predicted pattern, a strategy was formed by construction of

Kraftvärmens förutsättningar för flexibel elproduktion i Sveriges elsystem - En kvalitativ analys

Den här studien har som syfte att utreda om Sveriges kraftvärme kan bidra till ökad flexibel elproduktion och i så fall på vilket sätt. Detta undersöks genom att kombinera analys av tekniska, marknads- och regelverksmässiga förutsättningar för Sverige. Detta gjordes med inriktning på kraftvärmeverk i Skåne, exklusive egenproducenter av el samt industrikraftvärmeverk. Dessutom analyseras erfarenhetThis master thesis aims to investigate if and how Swedish Combined Heat and Power (CHP) plants can increase its flexibility in electricity production. This is examined through a combining analysis of technical, market-oriented and regulatory conditions for Swedish and primarily Skåne CHP plants, excluding autoproducers and industrial plants. Further, Danish CHP experiences are analysed and applied

The Role of Sexual Pleasure in Comprehensive Sexuality Education in International Development. A qualitative case study of RFSU and their partner organizations exploring sexual pleasure and its inclusion in CSE

The study examines pleasure-inclusive CSE within the case of RFSU and their partner organizations and their experiences of challenges and possibilities with CSE implementation and its cultural sensitivity. Experiences in both formal national CSE curricula such as in school- settings, and non-formal settings which reach out-of-school youth, such as in community centres or faith-based organizations,

“A Different World is Plantable”. A Case Study of How Alternative Food Initiatives Build Resilience and Promote Food Sovereignty in Franconia, Germany

It is increasingly recognised that the urgent need for more climate-adapted, context-appropriate and sustainable agro-food systems requires fundamental and crosscutting transformations. Alternative Food Initiatives (AFIs) have been proposed as one actor advancing transformation from the bottom up. This thesis contributes to existing research on AFIs relating to if and how they propose viable alter

Försiktighet, Förtänksamhet, och Finanspolitiska ramverk

Under det gångna decenniet sedan 2010 steg den genomsnittliga statsskulden bland 35 av medlemsländerna i Organisationen för ekonomiskt samarbete och utveckling (OECD) från 65,5 till 68,2 procent av BNP. Utgifterna för dessa länders auktoriserade förvaltningar överskrider deras inkomster i ökande utsträckning. Finanspolitiska ramverk är regelsystem för auktoriserade förvaltningars finanser vilka inDuring the past decade since 2010 the average general government debt among 35 of the members of the Organisation for Economic Co-operation and Development (OECD) increased from 65,5 to 68,2 percent of GDP. The expenditures of the governments of these countries are increasingly exceeding their revenues. Fiscal frameworks are systems of rules for the finances of governments which are institutionali

Applying Ecovillage Praxis to Foster Regeneration and Urban Socio-Ecological Transformation: An Exploratory Analysis of 5 Malmö Community Gardens

This research aims to fill the lacuna in the literature concerning the application of ecovillage praxis in spaces other than intentional communities by focusing on urban community gardens (UCGs) in Malmö, Sweden, as communities of practice where this could be integrated. It introduces both ecovillages and UCGs, as well as their associated praxis. Data was gathered about the first using semi-struct

Kriminalisering av deltagande i och samröre med kriminella gäng - Förslagets förenlighet med principer för kriminalisering och allmänprevention

Som ett resultat av ökad brottslighet inom den kriminella miljön kom det politiskt laddade förslaget att kriminalisera deltagande i och samröre med kriminella gäng. Uppsatsen syftar till att utreda om en sådan kriminalisering är rättfärdigad mot bakgrund av ett straffrättsideologiskt ramverk innehållande principer för kriminalisering. Utredningen görs även mot bakgrund av idén om allmänprevention,As a result of increased crimes in the criminal environment the politically charged proposal to criminalize participation in and association with criminal gangs was presented. This essay aims to investigate whether such criminalization is justified in the light of an ideological framework containing principles of criminalization. The investigation is also carried out on the basis of deterrence, wh