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Data-Driven Campaigning in Data-Dense Small Multiparty Systems: A Party-Level Analysis

This study examines data-driven campaign (DDC) practices in Sweden. We explore the extent of data-driven practices adopted in Swedish political campaigns, and parties’ motivations to adopt them. Since this is a comparison of domestic parties, we test the importance of four party-level factors—resources, structure, attitudes toward data use, and ideology—using extensive interviews with key campaign

Exploring transitions for marine environmental governance: the potential of communities and bottom-up processes as alternative pathways to sustainability

Panel for Pollen Conference in Lund 2024Exploring transitions for marine environmental governance: the potential of communities and bottom-up processes as alternative pathways to sustainabilityFacilitating the potential of communities and bottom-up governance for transitions to sustainability (T2S) sparks key questions of political ecology. Marine environmental governance exposes such challenges r

Automated multiplexed affinity-based enrichment of peptides for LC-MS/MS plasma proteomics

Plasma proteomics offers high potential for biomarker discovery, as plasma is collected through a minimally invasive procedure and constitutes the most complex human-derived proteome. However, the wide dynamic range poses a significant challenge. Here, we propose a semi-automated method based on the use of multiple single chain variable fragment antibodies, each enriching for peptides found in up

Transformative Local Governments: Addressing Social Urban Challenges by Bringing People and Politics Together : Editorial

As the tier of government closest to people, local government plays a key role in answering local needs and aspirations. However, local governments are often under-resourced, leaving them inadequately responsive to many of these critical local demands. Moreover, accountability to their citizens, which is the core of a well-functioning local democracy, is often lacking because the necessary formal

Surface effects on functional amyloid formation

Functional amyloids formed by the protein FapC in Pseudomonas bacteria are key structural components of Pseudomonas biofilms, which mediate chronic infections and also contribute to antimicrobial resistance. Here, we combine kinetic experiments with mechanistic modelling to probe the role of surfaces in FapC functional amyloid formation. We find that nucleation of new fibrils is predominantly hete

Virtual reality aggression prevention therapy (VRAPT) versus waiting list control for forensic psychiatric inpatients : A multicenter randomized controlled trial

Many forensic psychiatric inpatients have difficulties regulating aggressive behavior. Evidence of effective aggression treatments is limited. We designed and investigated the effectiveness of a transdiagnostic application of a virtual reality aggression prevention training (VRAPT). In this randomized controlled trial at four Dutch forensic psychiatric centers, 128 inpatients with aggressive behav

Immortalized mouse cell lines that lack a functional Rev3 gene are hypersensitive to UV irradiation and cisplatin treatment

The catalytic subunit of polymerase ζ is encoded from the Rev3 gene. The enzyme is conserved through eukaryotic evolution and its main function appears to be translesion synthesis (TLS) over damaged bases that stall DNA replication. In non-vertebrate cells, inactivation of polymerase ζ results in a moderate hypersensitivity to DNA damage but no proliferative defect in the absence of exogenous dama

Anticipating the impact of glaciers, landslides and extreme weather events on vulnerable hydropower projects and the development of an integrated multi-hazard warning system (IMWS)

The Himalayan river basins offer great potential for hydropower development, but they are also vulnerable to various hazards such as debris flows, landslides, flash floods, glacial lake outburst floods (GLOFs), and landslide lake outburst floods (LLOFs). Despite the regional and global significance of these hazards, there is a lack of information and data on different aspects, including meteorolog

Physicians’ intentions to use digital tools–a comparative survey, before and after the COVID-19 pandemic, in Southern Sweden

Objectives: To describe changes in Swedish primary care physicians’ use of, attitudes and intentions toward digital tools in patient care between 2019 and 2022. Design: A survey using a validated questionnaire measuring physician’s intentions to use digital tools based on the theory of planned behavior. Setting: Sample of primary health care centers in southern Sweden. Subjects: Primary care physi

Historical Memories of Aceh Chinese from 1965 to 2005

A number of anti-Chinese incidents in Indonesian demonstrated a complex relationship between the Chinese Indonesian,Indonesian state and local societies. While Aceh Chinese are considered as members of the Chinese Indonesian minority,the local politics of Aceh have profound impacts on the Aceh Chinese status and its social and political circumstance. The purpose of this paper is to investigate the

Reduction of fire spalling of concrete with small doses of polypropylene fibres

The addition of polypropylene (PP) fibres has been shown to reduce the fire spalling propensity of concrete. When including this type of fibres in the concrete, the concrete mix becomes less robust, and small deviations in the constitutes change the workability and properties of the concrete. So, from a manufacturing perspective as small dosages as possible of PP fibres are desirable. Very few lar

Stress and circulating cell-free mitochondrial DNA : A systematic review of human studies, physiological considerations, and technical recommendations

Cell-free mitochondrial DNA (cf-mtDNA) is a marker of inflammatory disease and a predictor of mortality, but little is known about cf-mtDNA in relation to psychobiology. A systematic review of the literature reveals that blood cf-mtDNA varies in response to common real-world stressors including psychopathology, acute psychological stress, and exercise. Moreover, cf-mtDNA is inducible within minute

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

Atherosclerosis is a major underlying cause of cardiovascular disease. Previous studies showed that inhibition of the co-stimulatory CD40 ligand (CD40L)-CD40 signaling axis profoundly attenuates atherosclerosis. As CD40L exerts multiple functions depending on the cell-cell interactions involved, we sought to investigate the function of the most relevant CD40L-expressing cell types in atheroscleros

A Fair Distribution of Responsibility for Climate Adaptation : Translating Principles of Distribution from an International to a Local Context

Distribution of responsibility is one of the main focus areas in discussions about climate change ethics. Most of these discussions deal with the distribution of responsibility for climate change mitigation at the international level. The aim of this paper is to investigate if and how these principles can be used to inform the search for a fair distribution of responsibility for climate change ada

Trust Matters : the Impact of In-group and Outgroup Trust on Nativism and Civicness

ObjectivesThe objectives of this study are threefold: first, we separate trust into a two-dimensional concept: ingroup trust and outgroup trust. Second, we apply both types of trust to two dependent variables: nativism and civicness, hypothesizing that respondents with ingroup trust should display higher degrees of nativism and lower degrees of civicness while the opposite should apply to responde

Aortic vessel wall characteristics and blood pressure in children with intrauterine growth retardation and abnormal foetal aortic blood flow

Blood pressure and pulsatile diameter changes of the abdominal aorta were measured in 68 children (mean age 9 years), with varying degrees of intrauterine growth retardation who were previously examined in their intrauterine life with Doppler velocimetry of the thoracic descending aorta. Diastolic blood pressure was lower (p < 0.05) and pulse pressure was increased (p < 0.01) in children with a bi

Tradeoffs in expressed major histocompatibility complex diversity seen on a macro‐evolutionary scale among songbirds

To survive organisms must defend themselves against pathogens. Classical Major Histocompatibility Complex (MHC) genes play a key role in pathogen defense by encoding molecules involved in pathogen recognition. MHC gene diversity influences the variety of pathogens individuals can recognize and respond to and has consequently been a popular genetic marker for disease resistance in ecology and evolu