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The transcription factor Wilms' tumor gene 1 (WT1) is highly expressed in the majority of leukemias, suggesting a role in leukemogenesis. Acquired WT1 mutations are reported as an independent predictor of poor clinical outcome, and mutations resulting in deletion of the entire DNA-binding zinc-finger domain (WT1delZ), is the most common type. The aim of this study was to study cellular effects of

This paper presents an alternative workflow for thermal comfort prediction. By using the leverage of Data Science & AI in combination with the power of computational design, the proposed methodology exploits the extensive comfort data provided by the ASHRAE Global Thermal Comfort Database II to generate more customised comfort prediction models. These models consider additional, often signific

In this paper we investigate the possibility of socially assistive robots (SARs) supporting diagnostic screening for peripartum depression (PPD) within the next five years. Through a HRI/socio-legal collaboration, we explore the gender norms within PPD in Sweden, to inform a gender-sensitive approach to designing SARs in such a setting, as well as governance implications. This is achieved through

The density of roots is an important factor influencing the rate and magnitude of landslides. Due to the increased variability in climate, mainly rainfall, Eastern Uganda is severely struck by an increasing number of these mass movements, often with human casualties as one of the negative impacts. The aim of this study is to explore the possibility to estimate the depth and density of the root sys

This article describes field monitoring and supplementary simulations of an existing daylighting and electric lighting integrated design for a furniture store. First in its type, the store includes several areas of the showroom provided with abundant daylighting. For the monitoring, the areas of the living rooms and the home decoration exhibitions were selected. They include wide glazed areas, day

This document presents design considerations of a sample for accelerated thermal aging tests. The proposed specimen is a parallel wired solenoid that is evaluated by using an axi-symmetric 2D finite element (FE) model in Comsol multi-physics. The aim of the design model is visualizing an interior stress distribution of an idealized coil in order to interpret the physics-of-failure in a more comple

In the ActivAbles and STARR projects we are developing interactive training tools for stroke survivors. Our initial user studies pointed to balance being a key ability, therefore one of the developed tools is an interactive balance pad. Equipment exists for persons with good balance (eg. Wii), but most consumer games and exercises are less suited for many stroke survivors. The development process

Huge dynamic Stark shifts of atomic energy levels in xenon induced by high-intensity laser light have been measured by a new method based upon multiphoton ionization by a tunable femtosecond laser source. Stark-induced multiphoton resonances appear as identifiable structures in the photoelectron energy spectra. The change in the structures positions, when the photon energy is tuned, is directly re

Purpose: Becoming widowed is a stressful health-threatening event causing major life changes. We explored how widowed people experience becoming widowed and examined if these experiences are quantitatively associated with widowhood. Methods: A multi-methods study using an exploratory sequential mixed-methods approach including a qualitative descriptive study with widowed people from Denmark and a

Since 1995, agri-environmental support partly funded by the EU has formed the core of Finland’s agri-environmental policy. This system has had a variety of impacts on the relationship between agriculture and the environment. Today’s agri-environmental support is one of the packages included in the Rural Development Programme for Mainland Finland (2007–2013/2014), which both in itself and through t

A number of deleterious health effects have been identified from exposure to outdoor air-borne particulate matter. This issue is complicated by the fact that people are spending most of the time indoors, where particles of both indoor and outdoor origin are present. The aim of this work was to assess the differences in particle chemical composition inside and outside of the residence and gain bett

Introduction: There is a need for new therapies that can enhance response rates and broaden the number of cancer indications where immunotherapies provide clinical benefit. CD40 targeting therapies provide an opportunity to meet this need by promoting priming of tumor-specific T cells and reverting the suppressive tumor microenvironment. This is supported by emerging clinical evidence demonstratin

This article offers an overview of the IsiXhosa Intellectual Traditions Digital Archive, which hosts digitized texts and images of early isiXhosa newspapers and books from 1870-1914. The archive offers new opportunities for a range of research across multiple fields, and responds to debates around the importance of African intellectual traditions and their indigenous language sources in generating

The advent of foundation models signals a new era in artificial intelligence. The Segment Anything Model (SAM) is the first foundation model for image segmentation. In this study, we evaluate SAM's ability to segment features from eye images recorded in virtual reality setups. The increasing requirement for annotated eye-image datasets presents a significant opportunity for SAM to redefine the lan

The objective is to investigate whether a silicon diode detector designed to measure the radiation levels in medical diagnostics also could be used as a dosemeter for people involved in the handling of a nuclear or radiological accident.

Occlusion is the most common reason for lowered recognition yield in free-flow license-plate reading systems. (Non-)occluded characters can readily be learned in separate neural networks but not together. Even a small proportion of occluded characters in the training set will already significantly reduce the overall recognition yield. This paper shows that a modular network can handle a realistic

We explore here, through three complementary experiments on virtual objects, how intimate active relations with multisensory audio-visual and haptics perceptions allow to the cognitive creation of new believable and plausible objects that can be different of the virtual ones objectively implemented. The three experiments are based on "Pebble Boxes" and consist in the exploration and the manipulati

We present an extension of the SPL-BEV (Soccer Player Localization for Bird’s-Eye-View) method, introducing Decomposable Tiled SPL-BEV (DTSPL-BEV), a variant designed to enable efficient inference on embedded devices. We show specialized tiling algorithms that enable inference on a given devices with some known memory limitations, while also ensuring the same detection results as running inference

As tech giants such as Apple and Meta invest heavily in Virtual and Augmented Reality (VR/AR) technologies, often collectively termed Extended Reality (XR) devices, a significant societal concern emerges: The use of eye-tracking technology within these devices. Gaze data holds immense value, revealing insights into user attention, health, and cognitive states. This raises substantial concerns over