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Most catalytic, structural and regulatory functions of the cell are carried out by functional modules, typically complexes containing or consisting of proteins. The composition and abundance of these complexes and the quantitative distribution of specific proteins across different modules are therefore of major significance in basic and translational biology. However, detection and quantification

Adeno Associated Virus (AAV)-mediated gene expression in the brain is widely applied in the preclinical setting to investigate the therapeutic potential of specific molecular targets, characterize various cellular functions, and model central nervous system (CNS) diseases. In therapeutic applications in the clinical setting, gene therapy offers several advantages over traditional pharmacological b

Technology of 3D printing is opening the possibility for small-scale production in quantities between ten and several hundred pieces. The technology of adding material enables the production of complex and integrated functional concepts in a single-pass process, which consequently potentially reduces the need for assembly operations. Design approaches and manufacturing processing are not mastered

We study cdcl-cuttingplanes, Open-WBO, and Sat4j, three successful solvers from the Pseudo-Boolean Competition 2016, and evaluate them by performing experiments on crafted benchmarks designed to be trivial for the cutting planes (CP) proof system underlying pseudo-Boolean (PB) proof search but yet potentially tricky for PB solvers. Our experiments demonstrate severe shortcomings in state-of-the-ar

The development of environmental certification schemes has increased rapidly during the last twenty years and are often used as benchmarks during design of new buildings or reconstruction. However, for management of our existing buildings the members of Sweden Green Building Council request for clear guidelines and a certification scheme. Therefore, a new certification scheme called Miljöbyggnad i

Summary: Chronic critical lower limb ischemia (CLI) has been defined as ischemia that endangers the leg. An attempt was made to give a precise definition of CLI, based on clinical and hemodynamic data (Second European Consensus). CLI may be easily defined from a clinical point of view as rest pain of the distal foot or gangrene or ulceration. It is probably useful to add leg ulcers of other origin

A variety of pathogenic bacteria can infect humans and the increase in bacteria resistant to common antibiotics is a large threat to human health worldwide. This work presents a method, based on optical DNA mapping (ODM) in nanofluidic channels, that can detect the type of bacterial present in a sample by matching the obtained maps of large DNA molecules to a database of fully assembled bacterial

PURPOSE: Current hypothesis regarding the mechanism of active tear drainage is based on studies performed ex vivo or under nonphysiological conditions. Novel ultra-high-frequency ultrasound has the advantage of generating images with superior resolution, enabling measurements of low flow in small vessels, and the tracking of tissue motion in real time. The purpose of this study was to investigate

Many scholars have regarded China's emergence as an economic force as a threat to democracy in Africa, presenting China as the exporter of an authoritarian model through its rising economic influence. This article investigates how well founded the contended Chinese economic threat to Africa is by both analyzing the data at a very fundamental level and applying time-series, cross-sectional analysis

Methane emissions from natural wetlands tend to increase with temperature and therefore may lead to a positive feedback under future climate change. However, their temperature response includes confounding factors and appears to differ on different time scales. Observed methane emissions depend strongly on temperature on a seasonal basis, but if the annual mean emissions are compared between sites

The financial crisis of 2008 resulted, among other, on a popular awareness that the monetary system was not working for the interest of the many. The blockchain technology that was launched soon after offered monetary activists and entrepreneurs a tool to re-imagine, re-claim and re-organize money along a vague ideal of a commons paradigm. A wave of monetary experimentation ensued that took a most

Natural habitats are rapidly declining due to urbanisation, with a concomitant decline in biodiversity in highly urbanised areas. Yet thousands of different species have colonised urban environments. These organisms are exposed to novel urban conditions, which are sometimes beneficial, but most often challenging, such as increased ambient temperature, chemicals, noise and light pollution, dietary

Volatile organic compounds of biogenic origin (BVOCs) in the atmosphere are a key component of the Earth system, influencing ozone and secondary organic aerosol formation, and the global oxidant budget. Global BVOC emissions are dominated by terrestrial vegetation, in particular the compound isoprene, whose emission rate, in common with many BVOCs, is strongly and non-linearly dependent on tempera

1. Carbon monoxide (CO), produced by haem oxygenase through degradation of haem, has been claimed to be a neuromessenger and a possible regulator of vascular tone. We examined whether the haem oxygenase inhibitor, zinc protoporphyrin-IX (ZnPP) and other porphyrins affect the relaxation evoked by various agents in the rat isolated aorta. 2. Pretreatment with ZnPP (0.1 mM) virtually abolished the re

The genetic control of insulin-dependent diabetes as well as of other autoimmune endocrine disorders have not been defined. These disorders are often said to run in families but the mode of inheritance is not understood. A most intriguing aspect of insulin-dependent diabetes is its close association with the HLA-DR specificities 3 and/or 4. More than 90% of all caucasian IDDM have either one or bo

In this chapter I begin by giving a brief snapshot of the recent re-emer- gence of the single-state solution as a potential political force, and of its alternative intellectual worldview against the Oslo Accords. Predominantly powered forward by the Palestinian Diaspora within the international arena today, it is this unified vision that holds the whole of the alternative together as a movement of

The loss of p53 induces spontaneous tumors in mice, and p53 mutations are found in approximately 50% of human tumors. These tumors are generally caused by a number of events, including genomic instability, checkpoint defects, mitotic defects, deregulation of transcriptional targets, impaired apoptosis, and G 1 deregulation or a combination of these effects. In order to determine the role of protei

Spermatozoa have a defined function, that is, the fertilization of an egg. To achieve this goal, spermatozoa have to move actively toward the egg and inject the male pronucleus into the egg. Therefore, sperm motility is one of the crucial determinants for male fertility. Surprisingly, however, structure and energy metabolism can differ substantially between spermatozoa from different species. Here

There is plenty of evidence that speech and gesture form a tightly integrated system, as reflected in parallelisms in language production, comprehension, and development (Kendon, 2004; McNeill, 1992). Yet, it is a common assumption that speakers use gestures to compensate for their expressive difficulties, a notion found in developmental studies of both first and second language acquisition, and i