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Avian pectoral muscle size rapidly tracks body mass changes during flight, fasting and fuelling

We used ultrasonic imaging to monitor short-term changes in the pectoral muscle size of captive red knots Calidris canutus. Pectoral muscle thickness changed rapidly and consistently in parallel with body mass changes caused by flight, fasting and fuelling. Four knots flew repeatedly for 10 h periods in a wind tunnel. Over this period, pectoral muscle thickness decreased in parallel with the decre

A probe for capture and Fe3+-induced conformational change of lactoferrin selected from phage displayed peptide libraries

Linear pentadecamer and cyclic hexamer peptide phage libraries were used to isolate phage clones with binding affinity toward lactoferrins purified from human and bovine milk. Phage clones with high specificity toward lactoferrin were selected with different binding strengths depending on the sequence of the peptide displayed by the phage. Phages coated to a microtiterplate were able to capture la

Testing for effects of climate change on competitive relationships and coexistence between two bird species.

Climate change is expected to have profound ecological effects, yet shifts in competitive abilities among species are rarely studied in this context. Blue tits (Cyanistes caeruleus) and great tits (Parus major) compete for food and roosting sites, yet coexist across much of their range. Climate change might thus change the competitive relationships and coexistence between these two species. Analys

Behaviour of nonsteroidal anti-inflammatory drugs and eight of their metabolites during wastewater treatment studied by hollow fibre liquid phase microextraction and liquid chromatography mass spectrometry.

In this work hollow fibre liquid phase microextraction combined with liquid chromatography mass spectrometry was applied for the determination of the nonsteroidal anti-inflammatory drugs (NSAIDs) ketoprofen, naproxen, diclofenac and ibuprofen as well as eight of their known human metabolites in wastewater samples. Extraction time and addition of tri-n-octylphosphine oxide (TOPO) to the liquid memb

Hormonal exposures and the risk of uveal melanoma

Several studies suggest that hormonal mechanisms may be associated with the development of uveal melanoma. Therefore, the association between the risk of uveal melanoma and exposure to hormonal exposures was investigated in a case-control study from nine European countries. Incident cases of uveal melanoma were frequency-matched to population and hospital controls by country, age, and sex. Female

Electrophysiology of pancreatic beta-cells in intact mouse islets of Langerhans

When exposed to intermediate glucose concentrations (6-16 mol/l), pancreatic beta-cells in intact islets generate bursts of action potentials (superimposed on depolarised plateaux) separated by repolarised electrically silent intervals. First described more than 40 years ago, these oscillations have continued to intrigue beta-cell electrophysiologists. To date, most studies of beta-cell ion channe

Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system

Genetic studies have implicated the neuronal ubiquitin C-terminal hydrolase (UCH) protein UCH-L1 in Parkinson's disease (PD) pathogenesis. Moreover, the function of UCH-L1 may be lost in the brains of PD and Alzheimer's disease patients. We have previously reported that the UCH-L1 polymorphic variant S18Y, potentially protective against PD in population studies, demonstrates specific antioxidant f

Interspecific observational memory in a non-caching Parus species, the great tit Parus major

Scatter-hoarding passerine birds have become a model system for research on spatial memory capacity. This research has focussed on two families, the Corvidae (crows, jays, nutcrackers, etc.) and the Paridae (titmice and chickadees). Corvids are considered to have highly developed cognitive skills that sometimes have been compared with the great apes. Even though pilfering, or stealing of caches ma

A model partitioning method based on dynamic decoupling for the efficient simulation of multibody systems

The presence of different time scales in a dynamic model significantly hampers the efficiency of its simulation. In multibody systems the fact is particularly relevant, as the mentioned time scales may be very different, due for example to the coexistence of mechanical components controlled by electronic drive units, and may also appear in conjunction with significant nonlinearities. This paper pr

The potential of smoking cessation programmes and a smoking ban in public places: comparing gain in life ex-pectancy and cost effectiveness.

BACKGROUND: Interventions aimed at reducing the number of smokers are generally believed to be cost effective. However as the cost of the interventions should be paid up front whereas the gains in life years only appear in the future--the budgetary consequences might be a barrier to implementing such interventions. AIMS: The aim of the present paper was to assess the long-term cost effectiveness

Glycaemic Response in Relation to Gastric Emptying and Satiety in Health and Disease

Dietary fibre and whole grains are recommended to prevent the development of type 2 diabetes. Low glycaemic index foods that are rich in fibre are recommended to control blood glucose levels. Gastric emptying, together with other factors, regulate the postprandial blood glucose response. A delay in the gastric emptying rate (GER) leads to a lower postprandial blood glucose concentration. However,

Post-historikern

The article discusses the identity, roles, and duties of the professional historian in an era in which the historical dimension is no longer a historian's monopoly. It is argued that the standard modern framework of understanding a historian as someone highly specialized in the production of 'new' history has to give way to a new understanding that situates the historian in historical culture, whi

Improving strategies for diagnosing ovarian cancer: a summary of the International Ovarian Tumor Analysis (IOTA) studies

In order to ensure that ovarian cancer patients access appropriate treatment to improve the outcome of this disease, accurate characterization before any surgery on ovarian pathology is essential. The International Ovarian Tumor Analysis (IOTA) collaboration has standardized the approach to the ultrasound description of adnexal pathology. A prospectively collected large database enabled previously

Det moraliska ifrågasättandet : alkoholmissbrukares upplevelser av och reaktioner på tvångsvård

Popular Abstract in Swedish Syftet med denna studie var att undersöka hur tvångsvård av alkoholmissbrukare upplevs av den som döms till det. Majoriteten av dessa personer är negativa till tvångsvård. I studien har också tagits hänsyn till att resultaten ses utifrån ett bredare perspektiv. Det som också undersökts är alkoholmissbruk generellt, varför klienterna dricker i den utsträckning de gör samThe aim of this study was to investigate how compulsary treatment of alcohol abuse is experienced by persons forced to submit to it, the majority of whom are negative in their attitude toward treatment of this sort. The importance of considering the resluts obtained not in isolation but within a larger context is emphasized. Among the elements of this context examined are alcohol abuse generally,

L-carnitine and haemodialysis: double blind study on muscle function and metabolism and peripheral nerve function

Twenty-eight haemodialysis patients were randomized to L-carnitine, 2 g i.v. three times a week, and saline over a 6-week period. No obvious deficiency of carnitine was found in vastus lateralis with a median value of 12.9 mmol/kg dry weight; range 6.2-21.4. Female patients had lower total plasma carnitine compared to female controls, p less than 0.002, whereas no decrease was found in males. No r

Responders and non-responders in a study on medical end-of-life decisions in Denmark, the Netherlands, Sweden and Switzerland

Objectives: To determine the direction and magnitude of participation bias in end-of-life research. Methods: Within the framework of a European survey on medical end-of-life decisions, a non-response study was conducted among physicians in Denmark, the Netherlands, Sweden and Switzerland. People were asked about their attitudes and experiences in the area of medial end-of-life decision. The respon

Long-term neuroretinal full-thickness transplants in a large animal model of severe retinitis pigmentosa.

The purpose of this study was to explore neuroretinal transplantation in a large animal model of severe retinitis pigmentosa and to establish graft development, long-term survival, graft-host integration, and effects on the host retina. Methods Rhodopsin transgenic pigs, aged 6 months, received in one eye a fetal full-thickness neuroretinal sheet in the subretinal space by means of vitrectomy and

Family characteristics and life events before the onset of autoimmune type 1 diabetes in young adults - A nationwide study

OBJECTIVE - To elucidate whether family characteristics and stressful life events were associated with onset of autoimmune type 1 diabetes in young adults. RESEARCH DESIGN AND METHODS - This investigation was based on a nation-wide study (Diabetes Incidence Study in Sweden) of newly diagnosed patients aged 15-34 years. Patients clinically classified as type 1 diabetic with antibodies to islet cell