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Background Assessment of myocardial sympathetic innervation with iodine-123-metaiodobenzylguanidine ([123I]mIBG) scintigraphy is conventionally performed by determining the heart-to-mediastinum ratio (HMR) on planar images. This study aimed to investigate the feasibility of determining HMR from reprojected [123I]mIBG planar images derived from tomographic data by a ring-configured cadmium-zinc-tel
The complex and varied relationship found in intermolecular interactions within the photo-active layers plays a decisive role in determining the photovoltaic energy conversion and overall device performance of organic solar cells (OSCs). Among different approaches, the ternary blend strategy serves as an effective technique to control the morphology within the active layer in OSCs. In this work, P
Cancer-associated fibroblasts (CAFs) are central architects of the tumor microenvironment (TME), influencing cancer progression, therapeutic response, and immune regulation. This thesis explores CAF heterogeneity and functional specialization in breast cancer through integrated single-cell transcriptomics, spatial proteomics, and functional studies.High-resolution analysis of murine and human data
Hepatitis A virus (HAV) remains a preventable cause of acute viral hepatitis, with an estimated 159 million new infections and 39 000 deaths in 2019. Although improved care and hygiene reduced deaths, global incidence rose by approximately 4%, driven by increased symptomatic cases and population growth. The availability of safe and highly immunogenic vaccines and the absence of chronic carriage ma
Carbon sequestration in arable soils is gaining increasing attention in global policymaking initiatives for climate-change mitigation. Large-scale assessments of soil organic carbon development in arable land are affected by the scarcity of reliable time series of soil organic carbon monitoring data and often fail to replicate observed trends or appreciate any effects induced by changes in soil ma
Engraved ochres and ostrich eggshells from the South African Blombos Cave and Diepkloof Rock Shelter are among the earliest expressions of human symbolic behavior. They appear to document a continuous practice of mark-making across ∼40,000 years. During this time, the engraved markings change from simpler, unstructured patterns to more complex markings such as cross-hatchings. Previous work examin
Naturbetesmarker och slåtterängar är bland de mest artrika miljöerna i det svenska jordbrukslandskapet och har därför en avgörande betydelse för bevarandet av biologisk mångfald. För att uppfylla kraven i EU:s Naturrestaureringsförordning och de nationella miljökvalitetsmålen krävs att Sverige både bevarar befintliga gräsmarker med höga naturvärden och restaurerar betydande arealer så att de erhål
Aims/hypothesis: The aetiology of type 1 diabetes remains elusive. Family history of type 1 diabetes increases the disease risk but the role of other autoimmune diseases or type 2 diabetes in the family are unclear. Here, we aimed to analyse the effect of family history of diabetes and autoimmune diseases on development of islet autoimmunity and progression to type 1 diabetes. Methods: The Environ
The rapid expansion of cross-border telework has exposed structural frictions between the European Union’s (EU’s) coordination of social security and the international allocation of taxing rights. This article examines how the simultaneous application of Regulation No. 883/2004 and double tax conventions affects the financing of social security systems. It first situates Member States’ heterogeneo
Background: Standardized care pathway (SCP) for macrohematuria (patients aged ≥50 years) in Sweden includes four-phase computed tomography urography (CTU) before cystoscopy, but targeted SCP lead time for CTU (6 days)/treatment is fulfilled in <25% of patients. Purpose: To retrospectively analyze the incidence of CTU-diagnosed upper urinary tract (UUT), kidney and bladder tumors, calculi, radiatio
Objective To train and validate a deep learning-based diagnostic tool capable of accurately segmenting the alveolar cleft region and automatically estimating the required bone graft volume using cone-beam computed tomography (CBCT) imaging. Study Design Eighty-eight CBCT scans from patients with nonsyndromic unilateral clefts were divided into training (n = 45), validation (n = 10), and test (n =
Acute postoperative pain remains common despite advances in surgical techniques and enhanced recovery protocols, suggesting that patient-specific factors and individualised approaches may be key to improving outcomes. Real-time intraoperative nociceptive monitoring has emerged as a potential tool to guide analgesia and predict postoperative pain bur their role in an individualised anaesthesia fram
Vi möter dagligen larmrapporter om att den regelbaserade världsordning som etablerades efter andra världskriget håller på att bryta samman. För den som vill få en förklaring till varför detta händer och en hum om vart världen är på väg finns en färsk analys att tillgå i Eswar Prasads The Doom Loop, i svensk översättning ungefär ”domedagsspiralen”.
The very concept of human rights implies governmental accountability. To ensure that governments are indeed held accountable for their treatment of citizens and others the United Nations has established a wide range of mechanisms to monitor compliance, and to seek to prevent as well as respond to violations.These essays critically examine the functions, procedures, and performance of each of the m
Accurate prediction of urban land use changes at fine spatial scales is essential for developing healthy and sustainable cities, yet traditional simulation models struggle to capture local dynamics due to limited availability of fine-grained data and insufficient complexity in modeling urban systems. To address these limitations, we propose a novel approach that leverages advances in pre-trained v
IntroductionBreast cancer is a heterogeneous disease in which imaging plays a central role. Beyond identifying malignancy, imaging provides information about the mammographic tumor appearance, breast density, and characteristics of the surrounding adipose tissue, which may reflect underlying tumor biology and relate to the prognosis. The aim of this thesis was to explore how features from mammogra
