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Introduction: HIV guidelines recommend switching from a three-drug regimen (3DR) to dolutegravir + lamivudine (DTG+3TC) for eligible individuals. This retrospective national cohort study used Swedish InfCareHIV registry data to evaluate long-term outcomes of adults with HIV RNA <50 copies/ml who switched to DTG+3TC or a guideline-recommended 3DR between July 2019 and May 2023 in routine clinical c
The bioeconomy promises to replace fossil resources with renewable biomass, assigning forests a central role in sustainability transitions. This dissertation tests that promise against the empirical record, using SWINNO, a database of significant commercialized innovations in Sweden linked to firm-register data, to trace fifty years (1970–2021) of forest-related innovation output. Four papers inve
The pathophysiology underlying various manifestations of cerebral small-vessel disease (cSVD) remains poorly understood. Using high-throughput proteomics, we identified common and distinct proteomic signatures of white matter lesions (WMLs), microbleeds, infarcts and their subtypes, measured in 1,670 living patients. Across all cSVD manifestations, markers of extracellular matrix dysregulation and
This doctoral thesis investigates mediaeval earthenware production, distribution and consumption based on material from Lund, Sweden, moving beyond simple technological shifts to explore the interplay of material factors, social practices, and economic influences. It presents a typology of hard greyware, redware and glazed redware, as well as the chemical analysis of circa 400 samples. The study a
Background: Fragrance allergens are a leading cause of contact allergy (CA). Linalool, common in cosmetics and household products, forms sensitising hydroperoxides (Lin-OOH) upon air exposure. Lin-OOH is linked to a high prevalence (3.9%–11.7%) of positive patch test results, but often gives rise to doubtful or irritant reactions. Objectives: To reassess patch test concentrations of Lin-OOH, deter
This chapter provides a normative analysis of the CJEU’s centre of gravity theory in legal basis litigation, exposing a number of flaws in its application and presenting suggestions for improvement. The chapter discusses the difficulties in the delimitation of competences under the current constitutional setup, the CJEU’s inconsistencies in applying the criteria of aim and content under the centre
Precipitates of the topologically close-packed (TCP) phases can significantly impact a material’s mechanical and fracture properties. This theoretical study uses ab initio modeling to investigate the σ phase of WOs, focusing on composition-dependent mechanical and fracture-related properties. We find the effect of Os on WOs σ to be stronger than that of Re in WRe σ phase, with the WOs phase exhibiPrecipitates of the topologically close-packed (TCP) phases can significantly impact a material’s mechanical and fracture properties. This theoretical study uses ab initio modeling to investigate the phase of WOs, focusing on composition-dependent mechanical and fracture-related properties. We find the effect of Os on WOs to be stronger than that of Re in WRe phase, with the WOs phase exhibiting p
Purpose: This article problematizes the dominant functionalistic and organization‑centric view of employees’ communication engagement on social media and challenges the assumption that such engagement merely reflects managerial success or failure. Adopting an employee‑centred, relational approach, the study advances the understanding of employees’ communication engagement by foregrounding the tensPurpose: This article problematizes the dominant functionalistic and organization‑centric view of employees’ communication engagement on social media and challenges the assumption that such engagement merely reflects managerial success or failure. Adopting an employee‑centred, relational approach, the study advances the understanding of employees’ communication engagement by foregrounding the tens
Light chain monoclonal gammopathy of undetermined significance (LC-MGUS) is an asymptomatic precursor of multiple myeloma (MM) and related disorders defined by abnormal free light chain (FLC) testing. Recently, revised FLC reference intervals were proposed by the iStopMM study group. We evaluated their performance in a large population-based cohort. MGUS cases were identified from the Danish Lymph
Correlations between event-by-event fluctuations of anisotropic flow harmonics are measured in Pb-Pb collisions at a center-of-mass energy per nucleon pair of 5.02 TeV, as recorded by the ALICE detector at the LHC. This study presents correlations up to the hexagonal flow harmonic v6, which was measured for the first time. The magnitudes of these higher-order correlations are found to vary as a fu
This paper presents the primary charged-particle multiplicity distributions in proton–lead collisions at a centre-of-mass energy per nucleon–nucleon collision of sNN=5.02 TeV. The distributions are reported for non-single diffractive collisions in different pseudorapidity ranges. The measurements are performed using the combined information from the Silicon Pixel Detector and the Forward Multiplic
The coherent J/ ψ photoproduction cross section is measured for the first time at midrapidity in peripheral to semicentral Pb−Pb collisions at sNN=5.02 TeV. The centrality differential cross section d σ /d y is reported for the centrality range 40–90%, together with the doubly-differential cross section d2 σ /d y d p T, extracted in two peripheral centrality classes. The J/ ψ mesons are reconstruc
This work reports femtoscopic correlations of p-−p(p‾-−p‾) and p−−d(p‾-−d‾) pairs measured in Pb–Pb collisions at center-of-mass energy per nucleon sNN = 5.02 TeV in the ALICE Collaboration. A fit to the measured proton-proton correlation functions allows one to extract the dependence of the nucleon femtoscopic radius of the particle-emitting source on the pair transverse mass (mT) and on the aver
Membrane channels are central to bladder function, yet current understanding is shaped disproportionately by a few well-studied families such as TRPA1 and TRPV1. To provide a more balanced view, this review analyzed emerging human transcriptomic datasets to identify the channels most highly expressed in the urinary bladder and examined how they remodel in bladder outlet obstruction and denervation
The momentum-differential invariant cross sections of π0 and η mesons are reported for pp collisions at = 13 TeV at midrapidity (|y| < 0.8). The measurement is performed in a broad transverse-momentum range of 0.2 < pT< 200 GeV/c and 0.4 < pT< 60 GeV/c for the π0 and η, respectively, extending the pT coverage of previous measurements. Transverse-mass-scaling violation of up to 60% at low transvers
