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Purpose/Aim of the study: Diabetic retinopathy (DR) is a leading cause of blindness in working age adults in developed countries. Changes in metabolites and in metabolic pathways of the retina caused by hyperglycemia may compromise the physiology of the retina. Using nuclear magnetic resonance (NMR) spectroscopy, we aimed to investigate the effect of diabetes on the levels of intermediate metaboli
Diabetic encephalopathy is a recognized complication of untreated diabetes resulting in a progressive cognitive impairment accompanied by modification of hippocampal function. The purinergic system is a promising novel target to control diabetic encephalopathy since it might simultaneously control hippocampal synaptic plasticity and glucose handling. We now tested whether streptozotocin-induced di
In this paper we revisit the Time-of-Arrival self-calibration problem. In particular we focus on imbalanced problem instances where there are significantly more sources compared to the number of receivers, which is a common configuration in real applications. Using an implicit representation, we are able to re-parameterize the sensor node self-calibration problem using only the parameters of the r
We propose a variation of the forward–backward splitting method for solving structured monotone inclusions. Our method integrates past iterates and two deviation vectors into the update equations. These deviation vectors bring flexibility to the algorithm and can be chosen arbitrarily as long as they together satisfy a norm condition. We present special cases where the deviation vectors, selected
Coherence is a useful measure in many engineering applications. Here, we focus on the case where the input signal to a linear system can be measured free from noise, but the output signal is perturbed by noise. A novel expression for the expectation of a multitaper magnitude squared coherence estimate for this case is presented and verified through numerical evaluation. Additionally, the expressio
The geometry-based stochastic channel models (GSCM), which can describe realistic channel impulse responses, often rely on the existence of both local and far scatterers. However, their visibility from both the base station (BS) and mobile station (MS) depends on their relative heights and positions. For example, the condition of visibility of a scatterer from the perspective of a BS is different
This study aimed to effectively decontaminate fuel oil-contaminated soil using ex-situ bioremediation. Soil samples (contaminated with waste oils) from Serbia were treated. The results showed several significant changes after bioremediation. The pH levels became slightly more alkaline (7.0–7.5). Reduction in organic substance (34%) and carbonate (36%) were observed, respectively. The concentration
Aims: Patients with heart failure (HF) exhibit poor prognosis, which is further deteriorated by pulmonary hypertension (PH), with negative impact on morbidity and mortality. As PH due to left HF (LHF-PH) is among the most common causes of PH, there is an urge according to the 2021 European Society of Cardiology HF guidelines to find new biomarkers that aid in prognostication of this patient cohort
This chapter focuses on the pharmacological management of newborn infants in the peri-extubation period to reduce the risk of re-intubation and prolonged mechanical ventilation. Drugs used to promote respiratory drive, reduce the risk of apnoea, reduce lung inflammation and avoid bronchospasm are critically assessed. When available, Cochrane reviews and randomised trials are used as the primary so
Cells have an incredible ability to physically interact with neighboring cells and their environment. They can detect and respond to mechanical forces by converting mechanical stimuli into biochemical signals in a process known as mechanotransduction. This is a key process for the adaption of vascular smooth muscle and endothelial cells to altered flow and pressure conditions. Mechanical stimuli,
