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Paracetamol overdosing may cause liver injury including fulminant liver failure due to generation of the toxic metabolites, N-acetyl-p-benzoquinone imine (NAPQI) and p-benzoquinone (p-BQ). Herein, the chelating agent, N,N'-Bis(2-mercaptoethyl)isophthalamide (NBMI), was examined for its potential ability to entrap NAPQI and p-BQ and to prevent paracetamol-induced liver injury. Both NBMI and the con
BACKGROUND: Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of this study is to investigate the differences in lung deposition of nanoparticles in the distal lung for healthy subjects and subjects with respiratory disease.METHODS: Lung depos
Social works’ relationship with the environment and the role of social workers in addressing environmental issues under climate change are usually neglected in mainstream practice. I begin this chapter by discussing the importance of social work as a field of research and practice that needs to actively carve out a position of expertise and engagement with emerging environmental issues at the micr
Emergence of a classical particle trajectory concept from the full quantum description is a key feature of quantum mechanics. Recent progress of solid-state on-demand sources has brought single-electron manipulation into the quantum regime; however, the quantum-to-classical crossover remains unprobed. Here we describe theoretically a mechanism for generating single-electron wave packets by tunneli
Antibodies targeting Ab42 are under intense scrutiny because of their therapeutic potential for Alzheimer’s disease. To enable systematic searches, we present an “antibody scanning” strategy for the generation of a panel of antibodies against Ab42. Each antibody in the panel is rationally designed to target a specific linear epitope, with the selected epitopes scanning the Ab42 sequence. By screen
Parkinson's disease (PD) is characterized by proteinaceous aggregates named Lewy Bodies and Lewy Neurites containing α-synuclein fibrils. The underlying aggregation mechanism of this protein is dominated by a secondary process at mildly acidic pH, as in endosomes and other organelles. This effect manifests as a strong acceleration of the aggregation in the presence of seeds and a weak dependence o
S-rapporten, ”en ny social bostadspolitik” levererar en bra problemanalys och flera goda målbeskrivningar men deras förslag orkar inte helt i mål, menar Ingemar Bengtsson, Universitetslektor vid Avdelningen för Fastighetsvetenskap, Lunds Universitet. Ingemar Bengtsson ifrågasätter gruppens allmänna strävan att samhället ska öka den samlade bostadskonsumtionen och efterlyser i följande kommentar me
The elegant cyclist: Cycling, fashion and femininity in Swedish and Danish women’s magazines at the turn of the 20th century.At the turn of the 20th century the new sport of cycling was endowed with femininity in Scandinavian ladies’ magazines. An analysis of the magazines Idun, Svensk Damtidning, Damernes Blad and Hjemmet between 1890 and the 1910s show that both Swedish and Danish magazines appe
Galectin-3 is an adhesion/growth-regulatory protein with a modular design comprising an N-terminal tail (NT, residues 1-111) and the conserved carbohydrate recognition domain (CRD, residues 112-250). The chimera-type galectin interacts with both glycan and peptide motifs. Complete (13)C/(15)N-assignment of the human protein makes NMR-based analysis of its structure beyond the CRD possible. Using t
Popular Abstract in Swedish De fyra essäerna i Sickness Insurance: Design and Behavior studerar sjukförsäkringens utformning ur både ett empiriskt och ett teoretiskt perspektiv. Den första essän bygger på en enkätstudie och innehåller två delar. I den första delen undersöks människors preferenser för olika utformningar av sjukförsäkringen, där de olika utformningarna förväntas ge ungefär samma kosThe first essay presents the results from a questionnaire study of sickness insurance and sickness absence behavior in Sweden. In the first part, people’s preferences for the design of a sickness insurance are discussed. Three combinations of qualifying days and compensation rates, with approximately the same costs within the insurance system, are compared. From the questionnaire it is concluded t
The IEEE P1687 (IJTAG) standard proposal aims at providing a standardized interface between the IEEE Standard 1149.1 test access port (TAP) and on-chip embedded test, debug and monitoring logic (instruments), such as scan-chains and temperature sensors. A key feature in P1687 is to include Segment Insertion Bits (SIBs) in the scan-path to allow flexibility both in designing the instrument access n
