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In the study of aggrecan fragmentation several methods to extract and purify aggrecan from cartilage and synovial fluid (SF) are used. This work compares and evaluates the effectiveness for purification of aggrecan of the most commonly used methods by the ratio of sulfated glycosaminoglycan (sGAG) to protein and by fragment analysis by Western blot. A novel method for purification of aggrecan frag

The aim of this investigation was to assess the Ku70/Ku80 complex as a potential target for antibody imaging of prostate cancer. We evaluated the in vivo and ex vivo tumor targeting and biodistribution of the (111)In-labeled human internalizing antibody, INCA-X ((111)In-DTPA-INCA-X antibody), in NMRI-nude mice bearing human PC-3, PC-3M-Lu2 or DU145 xenografts. DTPA-conjugated, non-labeled antibody

Age is the most important risk factor known for cardiovascular disease manifestations. However, the biological ageing of an individual may be substantially different from the chronological age in what has been called “differential ageing”. This process can be evaluated by arterial stiffness (pulse wave velocity), and the marker of telomere length and by levels of telomerase enzymatic activity. Sev

Seven mols. isolated from lichen species were tested as antioxidants and photoprotectors of UV-B (280-315 nm.) radiation. Perlatolic acid was the best of these seven mols. The decarboxythamnolic, usnic and usnic acid deriv. showed activity as photoprotectors. Finally, thamnolic acid showed good scavenging activity.

OBJECTIVES: The susceptibility to arsenic (As)-induced diseases differs greatly between individuals, probably to a large extent due to genetic differences in arsenic metabolism. The aim for this study was to identify genetic variants affecting arsenic metabolism. METHODS: We evaluated the association between urinary metabolite pattern and polymorphisms in three gene-groups related to arsenic metab

Paragone is a well-known and often applied category to discuss the interrelationship of the Sister Arts. However, it does not seem to be a sufficient label to respond to the general questions raised about representation, mimesis and identity brought together in the postmodern intermedial writing of The Matisse Stories (1993), by A.S. Byatt, which was influenced by French avant-garde literature and

Artikeln ger en översiktlig inblick i olika historiska exempel på kopplingen mellan typografi och politik.

Between the two world wars the typography of the Romanian newspapers followed the general development and the use of serif typefaces for the body type. The concern for the typography of the newspaper was rather conservative and worked a lot with the same kind of typography used for the fiction literature. After the communist take over in 1943 the typography of the newspapers followed the standards

Objective. To detect chronic heart failure in elderly patients with a registered diagnosis of chronic obstructive pulmonary disease (COPD) treated in Swedish primary health care using natriuretic peptide NT-proBNP. Design. A cross-sectional study. Setting. Two primary health care centres in southeastern Sweden each with about 9000 listed patients. Subjects. Patients aged 65 years and older with a

Background An early and accurate diagnosis of chronic heart failure is a big challenge for a general practitioner. Assessment of left ventricular function is essential for the diagnosis of heart failure and the prognosis. A gold standard for identifying left ventricular function is echocardiography. Echocardiography requires input from specialized care and has a limited access in Swedish primary h