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Background: Colorectal cancer (CRC) is shaped by a complex tumor immune microenvironment in which inflammatory mediators like cyclooxygenase-2 (COX-2) and immune checkpoints such as programmed cell death ligand 1 (PD-L1) play central regulatory roles. However, the prognostic significance of these makers, individually and in combination with T-cell infiltration, remains poorly defined.Methods: We i
This dataset presents a comprehensive collection of microscopic images, infrared (IR) spectra of particles obtained from beach sediment in Tioman Island, Malaysia. Sediment samples were collected from multiple sites across three selected beaches to identify material composition and assess the concentration of plastic particles, including both microplastics (<5 mm) and macroplastics (>5 mm), in the
A complication in the treatment of any strongly charged particle is the SU(3) color structure. For the standard model quarks, antiquarks and gluons there are various well-known strategies for dealing with the color structure, including orthogonal multiplet bases. For exotic representations, beyond triplets, antitriplets and octets, non-orthogonal bases have been systematically worked out only rece
This study systematically investigates the passivation and dissolution mechanisms of TC4 (Ti-6Al-4V) in 3.5 wt% NaCl solution using in situ electrochemical atomic force microscopy (ECAFM), complemented by X-ray photoelectron spectroscopy (XPS) and X-ray absorption spectroscopy (XAS). Potentiodynamic polarization initially identified the electrochemical behavior of TC4, delineating passive, dissolv
Antennae, the primary sensory organs of insects, contain numerous sensilla responsible for detecting chemical and physical stimuli essential for host location, communication, and orientation. Although the antennal sensilla of many insect groups—including Gelechiidae—have been well characterized, no such descriptions exist for Anacampsis phytomiella (Busck, 1914), a pest that exclusively infests ca
This study examined the role of a daytime nap in the consolidation and generalization of fear learning. 31 healthy, young adult participants (16 in the wake group and 15 in the sleep group) underwent a fear acquisition procedure in which the conditioned stimulus (CS+), a composite image consisting of a geometrical figure imposed on a background, was repeatedly paired with a mild electric shock. Th
This paper explores ‘utopia as method’ to envision solid waste and sewage management systems which are equitable and sustainable. Global solid waste management is largely sustained by millions of waste pickers who collect, sort and manage waste. Sanitation workers play a vital role in maintaining sewage systems. These workers are exposed to dangerous, toxic workspaces, and they often belong to mar
The urgency of global climate change and other geological-scale anthropogenic impacts also suggests new perspectives on economic history. This thesis argues for the inclusion into economic history of more Earth-system centred feedbacks, both in terms of environmental and climatic consequences and environmental and climatic causes, where consequences in one realm may again become causal in the othe
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To evaluate the benefits and harms of intratracheal instillation of corticosteroids combined with surfactant versus surfactant alone for the preventing chronic lung disease in preterm infants. Secondary objective To identify equity issues that may be associated with the implementation, uptake,
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases worldwide. In 2023, it accounted for approximately 1.25 million deaths, including 161,000 among individuals living with HIV, making it the leading cause of death from a single infectious agent. The growing prevalence of multidrug-resistant TB (MDR-TB) further complicates treatment and contribu
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, yet clinical tools for diagnosis, prognosis, and treatment remain limited, and molecular profiling of histotypes is lacking. Here, we leverage proteomic data to further stratify four main EOC histotypes, borderline (BL) and benign (B) tumors, and identify candidate prognostic and diagnostic biomarkers. Using proteomic data
Hair analysis has been used in the past as a method to explore environmental exposure to chemicals, toxins or drug ingestion, with wide applications in forensic science, environmental studies, anthropology and medicine. Although not a conventional sample type, hair offers significant advantages over traditional biospecimens, such as blood or urine. These include its stability, non-invasive nature
Compact automated warehouse solutions are a challenge for conventional fire protection systems, such as sprinklers. As an option to sprinkler systems some warehouses employ an Oxygen Reduction System (ORS). When designing an ORS, the most important parameter is the limiting oxygen concentration (LOC). The level of protection attained is directly proportional to the oxygen level applied, which is a
The Industrial Symbiosis Readiness Level Matrix (ISRLM) tool presented in this paper, was developed to address the challenges inherent in implementing and managing Industrial Symbiosis (IS) networks. IS networks are complex systems involving diverse actors with varying levels of preparedness, perspectives, and priorities, which can result in miscommunication, inefficiencies, and slow implementatio
Habitat area, forest characteristics, management practices and protected areas have the potential to profoundly impact biodiversity. This is particularly true for specialist species linked to structural complexity and old forest, like the lesser spotted woodpecker (Dryobates minor). This study examines how habitat quality and quantity influence the occurrence of this Near-Threatened species across
In liquid-liquid chromatography (LLC), components of a mixture are separated due to their different distribution between the phases of a biphasic liquid system composed of two or more solvents. In this work, for the first time, we combine a chromatography model with a liquid-liquid equilibria thermodynamic model to simulate the propagation of the solute and the solvents along the LLC column. The m
Objectives: Our aim was to compare direct costs for single pill combinations (SPCs) and free-drug combinations for hypertension treatment. Methods: We focused on Australia as a case study and reviewed total costs, and for the patient and government. We reviewed the Australian “Pharmaceutical Benefits Scheme item drug map” considering different thresholds for the government safety net. Total costs
Over the past decade, numerous assays for forensic age estimation based on the analysis of DNA methylation markers have been developed, demonstrating significant potential for use in criminal investigations. Despite these advancements, only few comprehensive evaluation studies were published. In this study, we present findings of an extensive inter-laboratory evaluation of the VISAGE Enhanced Tool
