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Adeno-associated viral vectors have become a leading choice for gene therapy in the central nervous system due to their safety profile, efficient neuronal transduction, and capacity for sustained transgene expression. We previously reported that AAV2-derived capsids developed using the BRAVE (Barcoded Rational AAV Vector Evolution) approach have enhanced retrograde transport properties in the rode

Purpose of review – Small cell lung cancer (SCLC), particularly its transdifferentiated form, is highly aggressive and has a poor prognosis. The diagnosis of SCLC transdifferentiation is challenging, as repeat biopsies are often not clinically feasible and few noninvasive predictors of this neuroendocrine transformation have been identified to date. Recent findings – Some retrospective studies and

Background: Normal hand function relies on a finely tuned interaction between the sensory and motor systems within the central and peripheral nervous systems. The central nervous system continuously adapts to changed activity, environmental changes, learning, and injury — a phenomenon known as neuroplasticity. The neuroplasticity is a life-long ability and presents opportunities for therapeutic in

The impact of the COVID-19 pandemic on building energy use has been studied across various countries. However, with the growing trend toward flexible working and the rising frequency of climate-induced extreme weather events, the combined effects of these factors on future energy use remain largely unexplored. This study develops a methodology to investigate the resilience of the UK's low-income h

Crustaceans inhabit a wide variety of habitats, from the open ocean to ephemeral pools. Within these habitats, crustaceans play key roles as herbivores, detritivores, and predators, and interact with competitors ranging from conspecifics to other crustaceans to diverse assemblages of invertebrates. As with most communities and ecosystems, efforts to understand the impacts of crustacean community d

We present a genome assembly from a female specimen of Podarcis vaucheri (Andalusian wall lizard; Chordata; Lepidosauria; Squamata; Lacertidae). The assembly contains two haplotypes with total lengths of 1,614.91 megabases and 1,510.74 megabases. Most of haplotype 1 (98.26%) is scaffolded into 20 chromosomal pseudomolecules, including the W and Z sex chromosomes. Most of haplotype 2 (98.63%) is sc

The 39.4% decline in numbers in the Northeast/Northwest European population of Bewick’s Swan Cygnus columbianus bewickii between 1995 (29,780 birds) and 2010 (18,057 birds) was of major conservation concern, alleviated by a partial recovery to 20,149 recorded in the January 2015 census. The most recent census, in January 2020, however found that the recovery was not sustained. The results describe

Viral hepatitis remains a global health concern, with growing recognition of the impact of hepatitis A virus (HAV), hepatitis E virus (HEV), and herpesvirus-associated hepatitis, particularly in vulnerable groups. This narrative review from the ESCMID Study Group for Viral Hepatitis (ESGVH) summarizes recent advances and expert perspectives. For HAV, insights into viral evolution, epidemiology, an

The increasing datafication of the workplace is often cast as a means of imposing organisational and managerial control on workers. This reflection note moves beyond this view and coins the term data-driven labour organising to discuss the potential of workplace datafication as a way to inform workers about their working conditions and how to use data to advocate for their collective goals. Forgin

Digital trace data can be used to capture organizational practices in granular detail and enable the automation of a wide range of managerial tasks. One example is Digital Productivity Assistants (DPA) that harness digital trace data about knowledge workers’ performance and make targeted suggestions for how to improve and optimize their work patterns. Previous research shows that despite benevolen

How do you feel about tracking your time? Some of you might welcome it and some might feel it’s an infringement on their freedom and privacy. Stig Nyman will bring some clarity on the topic in this week's episode, Stig is a Ph.D. student at the department for Digitalisation at Copenhagen Business School, he has dedicated his time to study the implications of being managed by an algorithm. His rese

We present a microchannel-based adaptation of mass density-gradient centrifugation for the mass density measurement of cells or microparticles. The workflow consists of three basic steps: Microchannel filling, centrifugation, and microscopy. Microchannel filling and subsequent centrifugation of two liquids with different densities allows the instantaneous, precise, and repeatable generation of a o

Ambient pressure X-ray photoelectron spectroscopy (APXPS) has emerged as an important technique for investigating surface and interface chemistry under realistic conditions, overcoming the limitations of conventional XPS restricted to ultrahigh vacuum. This review highlights the capabilities and scientific impact of APXPS at the MAX IV Laboratory, the world’s first fourth-generation synchrotron li

Studies of the Silurian sequence on Gotland have significantly advanced our understanding of Silurian climate dynamics, with much of the research focusing on small outcrops and short cores. Gotland has an extensive network of abandoned oil and gas wells. Most of these include gamma-ray well logs, which have not yet been fully utilised for their stratigraphic value. While the Ordovician succession

This dissertation coins the term algorithmic aspirational control (AAC) to describe an emergent configuration of algorithmic control. In this class of algorithmic management systems, computer-programmed procedures direct workers toward organizational goals through prompts, personal productivity dashboards, targeted algorithmic recommendations, and other forms of digital nudging. Drawing on Michel

AI methods allow for a multitude of new forms of managerial control. One is algorithmic nudging, in which organizations use AI methods to control workers through targeted recommendations. Drawing upon Michel Foucault's analytical strategies, the paper examines the intellectual heritage and ideological roots of AI-nudges. Scholars have commented on the resemblance between algorithmic nudging and Ta

Introduction: The transition from pediatric to adult healthcare represents a crucial period for adolescents and youth living with HIV. When this healthcare transition is not properly managed, it can result in negative outcomes such as loss to follow-up (LTFU), increased morbidity, and mortality. Therefore, it is essential to estimate the incidence rate and identify predictors of loss to follow-up