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Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationsh
In this paper, we applied Bayesian multi-layer perceptrons (MLP) using the evidence procedure to predict malignancy of ovarian masses in a large (n = 1,066) multi-centre data set. Automatic relevance determination (ARD) was used to select the most relevant inputs. Fivefold cross-validation (5CV) and repeated 5CV was used to select the optimal combination of input set and number of hidden neurons.
BACKGROUND: The CSF biomarkers tau and Abeta42 can identify patients with AD, even during the preclinical stages. However, previous studies on longitudinal changes of tau and Abeta42 in individual patients with AD and elderly controls report somewhat inconsistent results. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the levels of tau and Abeta42 at baseline and after 1 year in 100 patients with
The highly mobile wandering albatrosses (Diomedea exulans) are adapted to navigate the extreme environment of the Southern Ocean and return to isolated islands to breed. Each year they cover several hundreds of thousands of kilometers during travels across the sea. Little is known about the dispersal flights and migration of young albatrosses. We tracked, by satellite telemetry, the departure disp
Immunity against malaria develops slowly and only after repeated exposure to the parasite. Many of those that die of the disease are children under five years of age. Antibodies are an important part of immunity, but which antibodies that are protective and how these should be measured are still unclear. We discuss the pros and cons of ELISA, invasion inhibition assays/ADCI, and measurement of aff
Slurries obtained from process streams in a starch-to-ethanol plant, Agroetanol AB in Norrköping, Sweden, were used to assess the potential increase in bioethanol yield if heat treatment followed by enzymatic hydrolysis were applied to the residual starch-free cellulose and hemicellulose fractions. The effects of different pretreatment conditions on flour (the raw material), the stream after sacch
A well crystallized sample of EuAti(2)Ge(2) was synthesized by arc-melting of the elements. The structure was refined on the basis of single crystal X-ray diffractometer data: ThCr2Si2 type, 14/mmm, a = 447.3(1), c = 1034.0(4) pm, wR2 = 0.0575, 148 F-2 values and 9 variables. The gold atoms have tetrahedral germanium coordination (261 pm Au-Ge). These AuGe4/4 tetrahedra share four common edges, le
Kraft lignin was used to formulate adhesives in combination with polyethyleneimine, chitosan and soy protein, respectively. The tensile strengths of bond lines formulated with laccase-treated and untreated lignin were found to be similar. However, a remarkable difference was noted when laccase-treated lignin was reduced by sodium borohydride prior to reacting either with chitosan or soy protein -
Predicted alterations in belowground plant-allocated C as a result of environmental change may cause compositional shifts in soil microbial communities, and it has been hypothesized that such alterations will influence C mitigation in forest ecosystems. In order to investigate to what degree living trees influence the abundance and activity of mycorrhizal fungi, saprotrophic fungi, and bacteria we
Objectives. To establish the gender difference amongst newly diagnosed type 1 diabetic patients aged 15-34 years, considering age at diagnosis, temporal trend and seasonal variation at time of diagnosis. Study design. A population-based prospective study with a mean annual population at risk of 2.3 million. Setting. All departments of medicine, endocrinology and paediatrics and primary health care
Similar to other malignancies, urothelial carcinoma (UC) is characterized by specific recurrent chromosomal aberrations and gene mutations. However, the interconnection between specific genomic alterations, and how patterns of chromosomal alterations adhere to different molecular subgroups of UC, is less clear. We applied tiling resolution array CGH to 146 cases of UC and identified a number of re
Popular Abstract in Swedish Ofrivilligt urinläckage, urininkontinens, omfattar mer än 50 miljoner människor i världen, varav cirka 500 000 i Sverige. Av dessa beräknas 2/3 vara kvinnor. Ofrivilligt urinläckage är ett medicinskt och socialt handikapp för den drabbade, operation och hjälpmedel förorsakar samhället stora kostnader. Risken för urininkontinens ökar med stigande ålder. I svenska studierAbstract Pelvic floor disorders (PFD) represent a major public health issue worldwide. Aims of this work Study I: to investigate associations between preoperative resting urethral parameters (MUCP, FL and CA) and objective outcome of laparoscopic colposuspension and, if possible, to identify cutoff values useful in clinical practice. Study II: to investigate a group of perimenopausal women reporti
Popular Abstract in Swedish Det religiösa landskapet i Europa genomsyras av rituell kreativitet - inom teater, psykoterapi och religiösa samfund laborerar individer och grupper med rituella former under mer eller mindre obundna förutsättningar. En stor del av det rituella nyskapandet återfinns emellertid utanför de etablerade religiösa institutionerna och traditionens ortopraxi. Här ses ritualer oRitual creativity may seem like a contradiction in terms, yet the religious landscape in contemporary Euro-America is permeate with experimentation of ritual forms, different modalities of action, imagination and play as routes to authenticity. The present study examines different settings in Europe involved in such ritual creativity, which would commonly be classified as postmodern spirituality,
Regulation of mRNAs is one way to control protein levels and thereby important cellular processes such as growth, invasion and apoptosis. G3BPs constitute a family of mRNA-binding proteins, shown to be overexpressed in several cancer types, including breast, colon and pancreas cancer. G3BP has been reported to both stabilize and induce degradation of specific mRNAs.
