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The molecular mechanisms governing internal fluctuations in intrinsically disordered protein (IDP) assemblies are crucial to the stability and dynamics of both regulated and aberrant toxic cellular aggregates, but remain poorly understood. By comprehensively combining high-resolution quasi-elastic neutron scattering with all-atom molecular dynamics simulations, we probe the motions of β-casein, a
DEBATT. I tider av hög arbetslöshet och ökade matpriser riskerar många familjer att drabbas av ekonomisk utsatthet. Men barnfattigdomen i Sverige är kraftigt ojämnt fördelad. Vår ESO-rapport visar att risken att växa upp i fattigdom varierar med föräldrarnas arbetsmarknadsanknytning, familjens storlek och om barnet lever med en ensamstående förälder. Skillnaderna är stora mellan barn till utrikesf
Cryo-scanning electron microscopy (CryoSEM) permits the preparation and detailed imaging of bulky samples while keeping them in a hydrated state. For plant biology, cryofractures give information on cell ultrastructure and tissue organisation within a much larger context that is the whole organ or organism. To date, a method to locate fluorescence reporters on the cryofracture has not been reporte
Construction robot prototype for onsite work. Consists of an ABB IRB4600 mounted on a spindle crane chassi for mobility. Housed in a container for weather protection and logistics.
”Hur kan det europeiska storstadstornet rädda staden?” Ungefär så, och sett i motsats till den anglosaxiska skyskrapan, kan det projekt som genomsyrar den här boken formuleras..."
Background: Limited evidence exists for effect modification of genetic characteristics on the associations of food consumption and incident type 2 diabetes (T2D). Objectives: We aimed to investigate whether the food-T2D association would vary by genetic susceptibility to metabolic traits. Methods: We analyzed data from 9542 incident T2D cases and a subcohort of 12,477 participants nested within th
Relations between the European Union (EU) and Indonesia have expanded significantly in recent decades, yet public perceptions of the EU in Indonesia are shaped not only by contemporary policies but also by enduring postcolonial legacies. In postcolonial societies, global actors are often interpreted through historically grounded narratives that influence how authority, legitimacy, and partnership
As snow leopards (Panthera uncia) are vulnerable in the wild, individuals in captivity function as a backup for the wild population. However, space limitations make it difficult to keep the captive population healthy. To maintain high genetic diversity in the captive population, it is important to carefully consider breeding recommendations and the use of contraception. This study examined age-rel
Trichoderma are fungi that form symbiotic relationships with plant roots, representing an ecological topic for pest management. It offers a sustainable alternative to agrochemicals through biostimulation and biocontrol. However, the host plant needs to effectively manage a trade-off : using Trichoderma as a defense mechanism while not getting damaged by its cytotoxic compounds, like the antibiotic
Sammanfattning av Kapitel IV:Detta kapitel handlar om att kombinera Pre-kirurgisk strålbehandling och hypertermi (värmebehandling) med fokus på immunologiska effekter. Hypertermi (HT ca 41–44 °C) gör tumörceller mer känsliga för strålning (RT). Kliniska studier visar bättre respons och fler kompletta remissioner med kombinationen RT+HT jämfört med enbart strålning (RT) utan att öka allvarliga bive
Amyloid-β (Aβ) accumulation is a hallmark of Alzheimer’s disease. Cerebral Aβ deposition is attenuated by a functional glymphatic system, in which perivascular entry of cerebrospinal fluid (CSF) and its exchange with interstitial fluid mediate solute clearance. Parenchymal border macrophages (PBMs), positioned along glymphatic pathways, are emerging as important players for glymphatic clearance. H
