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The development of an N-body/hydrodynamic ‘surrogate’ model of the Milky Way (MW) – a model that resembles the MW in several key aspects after many Gyrs of evolution – would be extremely beneficial for Galactic Archaeology. Here, we present four new ‘surrogate’ models, all built with the nexus framework. The simulations contain stars, dark matter and gas. Our most sophisticated model allows gas to

Background: The prevalence of urinary incontinence (UI) and fecal incontinence (FI) are conditions that increase with age. Apart from few larger studies data on prevalence and severity of UI and FI is scarce, especially among the > 80 yrs. and data of birth cohort effects is lacking. Methods: The purpose of this study was to evaluate birth cohort effects on prevalence of UI and FI in the general o

In 2021, neutron structures of oxidised and reduced human manganese superoxide dismutase were published, suggesting several unexpected features, including deprotonated glutamate, tyrosine and histidine residues and a reduced Mn ion with two hydroxide ligands. We have used quantum refinement to evaluate whether alternative interpretations of the structures are possible, comparing many structural mo

This chapter explores the intricate dynamics of transnational Shia networks and their relationship with Iran, focusing on the latter's aspiration to dominate global Shiism and the resistance it faces. It analyzes the transnational character of Shia clerical networks, which have been pivotal in political and communal mobilization since the 1950s, particularly in Iraq. Post-1979, Iran leveraged thes

Climate litigation has been on the rise since the beginning of the century. However, the increased use of intersectionality by plaintiffs to highlight their particular vulnerability to climate change and its impacts remains understudied. This paper provides a review of eleven intersectional climate litigation cases, along with insights from a focus group of key informants, to examine the role of i

Hybrid energy systems have become a promising strategy for enhancing power utilization efficiency while preserving ecology. Previous research has predominantly focused on developing models with fixed ecological constraints. However, the fixed ecological constraints overlook dynamic ecological uncertainty and its interaction with operation decisions. This study proposes adaptive operating rules for

This study applies a cost-benefit analysis methodology to evaluate the socio-economic profitability of emergency phones and portable fire extinguishers for fires in Swedish road tunnels. The benefits of each component were determined through a qualitative assessment of emergency phones and a quantitative analysis of portable fire extinguishers. The findings indicate that emergency telephones are l

A second order expansion of the eigenvalues of a parameter perturbation of Hermitian matrices is derived using matrix decomposition methods. The method developed is then applied to give a novel proof of a second order approximation of the eigenvalues of a global perturbation of Hermitian matrices first described by M. Carlsson. The result generalizes an approximation given by G.W Stewart which tre

Cardiac arrest causes an abrupt cessation of circulation, which rapidly leads to global ischaemia and hypoxia. Immediate and competent care is vital, and even when the circulation has been restored, there is a profound risk of patients never regaining consciousness due to hypoxic–ischaemic brain injury, or death due recurrent cardiac arrest or multiorgan failure. The complex pattern of symptoms se

Most clinical laboratories measure total magnesium (tMg) which includes both the ionized (iMg) and bound forms. Only the ionized component is biologically active, and it may be influenced by acid-base status, plasma protein concentrations and electrolyte disturbances, potentially altering how well tMg reflects iMg. This multicenter observational study evaluated the relationship between tMg and iMg

Background: Swedish nationwide family and cancer data offer the largest global resource for study of familial cancer. We focus here on familial risks in prostate cancer (PC) with questions on risk in individuals from families of multiple affected members and association of familial risk with metastatic disease and survival. Methods: Familial relative risk of PC was estimated using standardized inc

While circular economy (CE) discourse emphasises technology-driven solutions and formal systems, cities in the Global South rely on grassroots waste workers (WWs) in the informal sector, who perform essential circular functions through waste collection, sorting, and recycling. In Delhi, informal WWs contribute substantially to material recovery and fill gaps left by formal solid waste management (

Objectives: Panax ginseng (P. ginseng, C.A. Meyer) is suggested to improve blood glucose regulation, but evidence remains inconsistent. We examined whether consuming P. ginseng as a preload before a carbohydrate-rich meal modulates postprandial glucose and insulin responses. Methods: In a randomized, double-blind, crossover trial, 22 healthy middle-aged adults consumed P. ginseng tablets containin

We report a radical extension of magnetic-resonance spectroscopy to the Terahertz (THz) spectral range by complete polarization-resolved measurement of the linear electromagnetic response of nuclear and electron spin associated magnetic resonance using principles of ellipsometry at high magnetic fields. This new method permits us to accurately test existing models and leads to discovery of new phy

The CRISPR/Cas9 system has emerged as a transformative tool in genome editing, playing a pivotal role in enabling precise genetic engineering. Achieving high on-target efficiency while minimizing off-target activity is critical for translating CRISPR/Cas9 into reliable experimental and therapeutic applications. Conventional off-target detection methods are labor-intensive and cost-prohibitive, lim