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To efficiently implement plasma and cerebrospinal fluid (CSF) biomarkers for staging and prognosis of Alzheimer disease (AD), we must understand their dynamics across disease progression. We analyzed participants from the Swedish BioFINDER-2 study with mass spectrometry measurements of plasma and CSF tau species, including eMTBR-tau243/MTBR-tau243 and phosphorylation occupancies (%p-tau). Disease
Pain avoidant behavior is a predictive factor for reduced function in children with persistent pain. A model to explain this is the Fear-Avoidance Model of Pain (FAM). In FAM pain-related fear plays an important role in the development and maintenance of avoidant behavior. The Fear of Pain Questionnaire-Child Report Short Form (FOPQC-SF) was developed to assess pain-related fear in children 8 to 1
OBJECTIVES: To investigate the progression of radiographic damage in hands and feet of patients with early rheumatoid arthritis monitored prospectively for 15 years, and to search for predictors.METHODS: This study comprises 990 patients from the BARFOT cohort, included 1992-2006. Radiographs of the hands and feet were performed over time and evaluated by the Sharp van der Heijde scoring (SHS) met
BACKGROUND: Turning performance is an important and challenging motor activity, with potential relevance in several brain diseases. This study aimed to determine how Alzheimer's and vascular pathologies are associated with turning (360° while standing and 180° while walking), both as a single task and during dual-tasking in cognitively healthy older people.METHODS: Cognitively healthy older people
BACKGROUND: Obesity assessed at a single time point in adulthood has shown no consistent association with prostate cancer (PCa) incidence but has been positively associated with PCa death. We investigated the association of total and age-specific adult weight trajectories with PCa aggressiveness and death.METHODS: We analyzed data from 258,494 men in Sweden with at least 3 weight observations betw
Connect fundamental HPH principles directly to industrial process optimisationIndustrial high-pressure homogenisers have operated for over a century, yet mechanistic understanding has only recently emerged. High-Pressure Homogenisation connects these fundamental insights with practical applications in food, pharmaceutical, petroleum, and chemical processing. Written by Andreas Håkansson, who h
BACKGROUND: Almost a decade ago, about half of biomedical PhD programs across Europe specifically stated that systematic reviews could not be accepted as part of a doctoral thesis, illustrating limited merit value at that time. The aim of this study was to explore current Swedish university policies on this research design.METHODS: Policy documents for PhD theses and applications to associate prof
Poikilosis is a recently introduced unifying theory in biology. It is based on the pervasive heterogeneity of all biological molecules, complexes, systems, networks, cells, organisms, and others. In a relaxed situation, such entities, called levels, are in an energetically favorable state called lagom. These states are maintained actively and passively by TARAR (tolerance, avoidance, repair, atten
INTRODUCTION: Knowledge about the quantity, delivery and setting of rehabilitation after stroke in clinical practice is sparse. We investigated the utilisation of rehabilitation services in a regional cohort up to 2 years after stroke.PATIENTS AND METHODS: Data on people living in ordinary housing in southern Sweden with a first-ever stroke during 2016-2017 were collected from the Swedish Stroke R
BACKGROUND: Key tasks in the development of guideline recommendations include determining the magnitude of desirable and undesirable health effects, the overall net effect and assessing the certainty of evidence. Developing and using decision thresholds can support these tasks and increase transparency, however evidence of the procedural steps is limited. We describe a systematic, step-by-step app
BACKGROUND AND OBJECTIVES: Health guidelines play a central role in informing clinical practice, public health measures and health policy. But their trustworthiness may be undermined by factors such as insufficient methodological rigor, lack of transparency, conflicts of interest, and inconsistent application of established standards. Existing appraisal tools address selected aspects of guideline
Saussure e grida is an Italian-language popular science podcast about linguistics and the science of language. Each episode explores linguistic phenomena, theories, and research, drawing on scientific literature while making current linguistic knowledge accessible and engaging to a general audience. The podcast covers topics ranging from language structure and acquisition to language change, multi
For most organisms, we rely on the ability to observe them from birth to death in order to fully understand their ecology, life cycles, adaptations, and interactions with other organisms. For fungi, this is a challenge, and little is known about how old they can become and in what form they persist in the environment. In this opinion article, we highlight the complexity of determining the longevitFor most organisms, we rely on the ability to observe them from birth to death in order to fully understand their ecology, life cycles, adaptations, and interactions with other organisms. For fungi, this is a challenge, and little is known about how old they can become and in what form they persist in the environment. In this opinion article, we highlight the complexity of determining the longevit
While we are beginning to understand that the plant microbiome is important for plant health, we still lack information about how plant microbiomes are shaped across environments and how they influence plant performance, in particular, in wild study species.Here, we examined the root microbiota of the perennial vine Solanum dulcamara, a wild relative of potato with an unusually wide ecological ampWhile we are beginning to understand that the plant microbiome is important for plant health, we still lack information about how plant microbiomes are shaped across environments and how they influence plant performance, in particular, in wild study species.Here, we examined the root microbiota of the perennial vine Solanum dulcamara, a wild relative of potato with an unusually wide ecological amp
This article reflects on unresolved affective tensions in the field, not as failures or impasses but as analytical tools for (un)doing research. Shifting from a distant and detached analysis of my interlocutors’ narratives towards a decentred account of myself, I trace my disorientations, discomforts and troubles in encounters with queer refugees and asylum seekers. Through this ephemeral self-acc
AbstractBackground:Multidrug-resistant Acinetobacter baumannii remains as a global concern with its ability to adhere, disperse and sustain on areas involving suboptimal infection control measures, especially war zones. We aimed to evaluate the molecular epidemiology and virulence factors of A. baumannii isolates from conflict zone in Ukraine.Methods:In 2022, 46 A. baumannii wound isolates were re
Community-aqcuired pneumonia (CAP) is one of the most common infectious causes leading to hospitalization. Historically, Streptococcous pneumoniae has been the most common etiology in CAP and has therefor led to targeted interventions such as immunization in children, the elderly, and risk groups. Other important pathogens are Haemophilus influenzae, Mycoplasma pneumoniae and respiratory viruses.T
